miR-34a induces immunosuppression in colorectal carcinoma through modulating a SIRT1/NF-κB/B7-H3/TNF-α axis

A Systemic Review on the Regulatory Roles of miR-34a in Gastrointestinal Cancer

(2020) Jiehong Kong et al.   OncoTargets and Therapy

B7-H3 is spliced by SRSF3 in colorectal cancer

(2020) Chunxia Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

miR-125b upregulates miR-34a and sequentially activates stress adaption and cell death mechanisms in Multiple Myeloma

(2019) Gabriella Misso et al.   Molecular Therapy-Nucleic Acids

miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling

(2019) Martin Hart et al.   Cell Death & Disease

The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7-H3

(2017) Murali Janakiram et al.   IMMUNOLOGICAL REVIEWS

Identification of targets of tumor suppressor microRNA-34a using a reporter library system

(2017) Yoshiaki Ito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis

(2017) Mariola Kurowska-Stolarska et al.   Nature Communications

A polymorphism in the promoter region of PD-L1 serves as a binding-site for SP1 and is associated with PD-L1 overexpression and increased occurrence of gastric cancer

(2016) Li-Hua Tao et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint

(2016) Shaohua Xu et al.   Nature Communications

TGF-β1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis

(2016) Xinru Zhou et al.   Oncotarget

Reduction of c-Fos via Overexpression of miR-34a Results in Enhancement of TNF- Production by LPS in Neutrophils from Myelodysplastic Syndrome Patients

(2016) Yayoi Shikama et al.   PLoS One

Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia

(2015) Xi Wang et al.   CELLULAR SIGNALLING

PDL1 Regulation by p53 via miR-34

(2015) Maria Angelica Cortez et al.   JNCI-Journal of the National Cancer Institute

CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling

(2015) S Ventura et al.   ONCOGENE

PDL1 Regulation by p53 via miR-34

(2015) Maria Angelica Cortez et al.   JNCI-Journal of the National Cancer Institute

miR-34: from bench to bedside

(2015) Massimiliano Agostini et al.   Oncotarget

Dysregulated miR-34a–SIRT1–Acetyl p65 Axis Is a Potential Mediator of Immune Activation in the Colon during Chronic Simian Immunodeficiency Virus Infection of Rhesus Macaques

(2014) Mahesh Mohan et al.   JOURNAL OF IMMUNOLOGY

miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer

(2014) J Gao et al.   ONCOGENE

In Vivo Activity of MiR-34a Mimics Delivered by Stable Nucleic Acid Lipid Particles (SNALPs) against Multiple Myeloma

(2014) Maria Teresa Di Martino et al.   PLoS One

Transferrin-Conjugated SNALPs Encapsulating 2′-O-Methylated miR-34a for the Treatment of Multiple Myeloma

(2014) Immacolata Scognamiglio et al.   Biomed Research International

Mir-34: A New Weapon Against Cancer?

(2014) Gabriella Misso et al.   Molecular Therapy-Nucleic Acids

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma

(2012) Pengyuan Yang et al.   CANCER CELL

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

(2012) Yan Wang et al.   CANCER CELL

Epithelial-Mesenchymal Transition Induced by TNF-  Requires NF- B-Mediated Transcriptional Upregulation of Twist1

(2012) C.-W. Li et al.   CANCER RESEARCH

B7-H3 Participates in the Development of Experimental Pneumococcal Meningitis by Augmentation of the Inflammatory Response via a TLR2-Dependent Mechanism

(2012) X. Chen et al.   JOURNAL OF IMMUNOLOGY

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D

(2011) A. Heinemann et al.   CANCER RESEARCH

Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma

(2010) Jing Sun et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer

(2010) Dmitri Lodygin et al.   CELL CYCLE

MicroRNA miR-29 Modulates Expression of Immunoinhibitory Molecule B7-H3: Potential Implications for Immune Based Therapy of Human Solid Tumors

(2009) H. Xu et al.   CANCER RESEARCH

The miR-34 family in cancer and apoptosis

(2009) H Hermeking   CELL DEATH AND DIFFERENTIATION

Overlapping expression of microRNAs in human embryonic colon and colorectal cancer

(2008) Mariano Monzo et al.   CELL RESEARCH

MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon Adenocarcinoma

(2008) Aaron J. Schetter et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses

(2008) M. Hashiguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA