A polymorphism in the promoter region of PD-L1 serves as a binding-site for SP1 and is associated with PD-L1 overexpression and increased occurrence of gastric cancer

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

(2016) Keisuke Kataoka et al.   NATURE

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The polymorphic terminal-loop of pre-miR-1307 binding with MBNL1 contributes to colorectal carcinogenesis via interference with Dicer1 recruitment

(2015) Rong Tang et al.   CARCINOGENESIS

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation

(2015) Dong-Sheng Huang et al.   EUROPEAN JOURNAL OF CANCER

Sp1 and the ‘hallmarks of cancer’

(2015) Kate Beishline et al.   FEBS Journal

Association ofMMP7−181A→G Promoter Polymorphism with Gastric Cancer Risk

(2015) Kousik Kesh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sp1 transcription factor: A long-standing target in cancer chemotherapy

(2015) Carolina Vizcaíno et al.   PHARMACOLOGY & THERAPEUTICS

MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer

(2014) Tianzhu Qiu et al.   FEBS LETTERS

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-513 Regulates B7-H1 Translation and Is Involved in IFN- -Induced B7-H1 Expression in Cholangiocytes

(2014) A.-Y. Gong et al.   JOURNAL OF IMMUNOLOGY

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

(2014) Thomas Powles et al.   NATURE

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS

(2014) Yawei Liu et al.   NATURE MEDICINE

The -1082A>G polymorphism in promoter region of interleukin-10 and risk of digestive cancer: a meta-analysis

(2014) Chunxue Li et al.   Scientific Reports

A miR-570 binding site polymorphism in the B7-H1 gene is associated with the risk of gastric adenocarcinoma

(2013) Weipeng Wang et al.   HUMAN GENETICS

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

A functional single nucleotide polymorphism at the promoter region of cyclin A2 is associated with increased risk of colon, liver, and lung cancers

(2011) Duk-Hwan Kim et al.   CANCER

Immunoregulatory Molecule B7-H1 (CD274) Contributes to Skin Carcinogenesis

(2011) Y. Cao et al.   CANCER RESEARCH

A frequent somatic mutation in CD274 3′-UTR leads to protein over-expression in gastric cancer by disrupting miR-570 binding

(2011) Weipeng Wang et al.   HUMAN MUTATION

Matrix metalloproteinase3 gene promoter polymorphisms and their haplotypes are associated with gastric cancer risk in eastern Indian population

(2011) Sanjib Dey et al.   MOLECULAR CARCINOGENESIS

Interferon-  and tumor necrosis factor-  induce an immunoinhibitory molecule, B7-H1, via nuclear factor- B activation in blasts in myelodysplastic syndromes

(2010) A. Kondo et al.   BLOOD

B7-H1 Overexpression Regulates Epithelial–Mesenchymal Transition and Accelerates Carcinogenesis in Skin

(2010) Yujia Cao et al.   CANCER RESEARCH

Is there a role for second-line chemotherapy in advanced gastric cancer?

(2009) Robert Wesolowski et al.   LANCET ONCOLOGY

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

(2008) M. Marzec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The complex role of B7 molecules in tumor immunology

(2008) Barbara Seliger et al.   TRENDS IN MOLECULAR MEDICINE