kTWAS: integrating kernel machine with transcriptome-wide association studies improves statistical power and reveals novel genes

Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population

(2020) Prashantha Hebbar et al.   Scientific Reports

A Fast and Accurate Method for Genome-Wide Time-to-Event Data Analysis and Its Application to UK Biobank

(2020) Wenjian Bi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Opportunities and challenges for transcriptome-wide association studies

(2019) Michael Wainberg et al.   NATURE GENETICS

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

(2019) Laura M. Huckins et al.   NATURE GENETICS

Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

(2019) Rinki Ratnapriya et al.   NATURE GENETICS

A statistical framework for cross-tissue transcriptome-wide association analysis

(2019) Yiming Hu et al.   NATURE GENETICS

Transcriptome-wide association study identifies new candidate susceptibility genes for glioma

(2019) Isabelle Atkins et al.   CANCER RESEARCH

Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation

(2019) Biao Zeng et al.   GENETICS

Limits to compensatory mutations: Insights from temperature-sensitive alleles

(2019) Katarzyna Tomala et al.   MOLECULAR BIOLOGY AND EVOLUTION

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

(2019) Wen Zhang et al.   Nature Communications

UK Biobank Whole-Exome Sequence Binary Phenome Analysis with Robust Region-Based Rare-Variant Test

(2019) Zhangchen Zhao et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The N-terminal of NBPF15 causes multiple types of aggregates and mediates phase transition

(2019) Han Wu et al.   BIOCHEMICAL JOURNAL

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits

(2018) Farhad Hormozdiari et al.   NATURE GENETICS

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

(2018) Alexander Gusev et al.   NATURE GENETICS

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis

(2018) Sébastien Thériault et al.   Nature Communications

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

(2018) Alvaro N. Barbeira et al.   Nature Communications

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

(2018) Wei Zhou et al.   NATURE GENETICS

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

(2018) Nicholas Mancuso et al.   Nature Communications

Transcriptome-wide association study identifies multiple genes and pathways associated with pancreatic cancer

(2018) Liuyun Gong et al.   Cancer Medicine

A Powerful Framework for Integrating eQTL and GWAS Summary Data

(2017) Zhiyuan Xu et al.   GENETICS

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder

(2017) Ryan K C Yuen et al.   NATURE NEUROSCIENCE

Imaging-wide association study: Integrating imaging endophenotypes in GWAS

(2017) Zhiyuan Xu et al.   NEUROIMAGE

A Powerful Framework for Integrating eQTL and GWAS Summary Data

(2017) Zhiyuan Xu et al.   GENETICS

Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57

(2016) Mads Bak et al.   BMC Medical Genetics

Genome-wide changes in lncRNA, splicing and regional gene expression patterns in autism

(2016) Neelroop N. Parikshak et al.   NATURE

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Cis-eQTLs regulate reducedLST1gene andNCR3gene expression and contribute to increased autoimmune disease risk: Table 1.

(2016) Guiyou Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster

(2016) Hirokazu Okada et al.   Nature Communications

ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes

(2016) Guodong Pan et al.   Journal of Diabetes Research

A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: Role of AMPK-regulated autophagy

(2015) Yuli Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Testing and estimation in marker-set association study using semiparametric quantile regression kernel machine

(2015) Dehan Kong et al.   BIOMETRICS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

A gene-based association method for mapping traits using reference transcriptome data

(2015) Eric R Gamazon et al.   NATURE GENETICS

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

CYP21A2 polymorphisms in patients with autoimmune Addison's disease, and linkage disequilibrium to HLA risk alleles

(2014) Ingeborg Brønstad et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Using extended pedigrees to identify novel autism spectrum disorder (ASD) candidate genes

(2014) Marc Woodbury-Smith et al.   HUMAN GENETICS

The Cerebellum, Sensitive Periods, and Autism

(2014) Samuel S.-H. Wang et al.   NEURON

Identification of novel risk genes associated with type 1 diabetes mellitus using a genome-wide gene-based association analysis

(2014) Ying-Hua Qiu et al.   Journal of Diabetes Investigation

AprioriGWAS, a New Pattern Mining Strategy for Detecting Genetic Variants Associated with Disease through Interaction Effects

(2014) Qingrun Zhang et al.   PLoS Computational Biology

General Framework for Meta-analysis of Rare Variants in Sequencing Association Studies

(2013) Seunggeun Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Sequence Kernel Association Tests for the Combined Effect of Rare and Common Variants

(2013) Iuliana Ionita-Laza et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic evidence for the involvement of NOTCH4 in rheumatoid arthritis and alopecia areata

(2013) Suad AlFadhli et al.   IMMUNOLOGY LETTERS

Exome sequencing identifies novel rheumatoid arthritis-susceptible variants in the BTNL2

(2013) Shigeki Mitsunaga et al.   JOURNAL OF HUMAN GENETICS

Massive genomic variation and strong selection in Arabidopsis thaliana lines from Sweden

(2013) Quan Long et al.   NATURE GENETICS

Evolutionary History and Genome Organization of DUF1220 Protein Domains

(2013) Majesta S. O’Bleness et al.   G3-Genes Genomes Genetics

Polygenic Modeling with Bayesian Sparse Linear Mixed Models

(2013) Xiang Zhou et al.   PLoS Genetics

Evolution of Human-Specific Neural SRGAP2 Genes by Incomplete Segmental Duplication

(2012) Megan Y. Dennis et al.   CELL

Consensus Paper: Pathological Role of the Cerebellum in Autism

(2012) S. Hossein Fatemi et al.   CEREBELLUM

Notch signaling in diabetic nephropathy

(2012) Ramon Bonegio et al.   EXPERIMENTAL CELL RESEARCH

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

(2011) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ROADTRIPS: Case-Control Association Testing with Partially or Completely Unknown Population and Pedigree Structure

(2010) Timothy Thornton et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Powerful SNP-Set Analysis for Case-Control Genome-wide Association Studies

(2010) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Compensatory Mutations Restore Fitness during the Evolution of Dihydrofolate Reductase

(2010) K. M. Brown et al.   MOLECULAR BIOLOGY AND EVOLUTION

Variance component model to account for sample structure in genome-wide association studies

(2010) Hyun Min Kang et al.   NATURE GENETICS

The Type 1 Diabetes - HLA Susceptibility Interactome - Identification of HLA Genotype-Specific Disease Genes for Type 1 Diabetes

(2010) Caroline Brorsson et al.   PLoS One

Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci

(2009) Charlotte Vignal et al.   ARTHRITIS AND RHEUMATISM

Detecting disease-associated genotype patterns

(2009) Quan Long et al.   BMC BIOINFORMATICS

Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data

(2009) C. Brorsson et al.   DIABETES OBESITY & METABOLISM

Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA

(2009) I Santin et al.   GENES AND IMMUNITY

Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex

(2009) M K Viken et al.   GENES AND IMMUNITY

Expression Profiling of Human Genetic and Protein Interaction Networks in Type 1 Diabetes

(2009) Regine Bergholdt et al.   PLoS One

A Unified Association Analysis Approach for Family and Unrelated Samples Correcting for Stratification

(2008) Xiaofeng Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS