Discovery of CAPE derivatives as dual EGFR and CSK inhibitors with anticancer activity in a murine model of hepatocellular carcinoma

The effects and mechanisms of a biosynthetic ginsenoside 3β,12β-Di-O-Glc-PPD on non-small cell lung cancer

(2019) Lu-Lu Huang et al.   OncoTargets and Therapy

Correlations between chromobox homolog 8 and key factors of epithelial–mesenchymal transition in hepatocellular carcinoma

(2019) Xiaonian Zhu et al.   Cancer Cell International

IFI44L is a novel tumor suppressor in human hepatocellular carcinoma affecting cancer stemness, metastasis, and drug resistance via regulating met/Src signaling pathway

(2018) Wei-Chieh Huang et al.   BMC CANCER

Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury

(2018) Lingfeng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Caffeic Acid Phenethyl Ester Induces N-myc Downstream Regulated Gene 1 to Inhibit Cell Proliferation and Invasion of Human Nasopharyngeal Cancer Cells

(2018) Kun-Chun Chiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Design, synthesis of a novel 4-O-methylsaucerneol analogue LXY7824 as potent HIF-1 inhibitor and anti-cancer agent

(2018) Xiao-Yu Liu et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy

(2018) Hongwei Xia et al.   Cell Death & Disease

HCRP-1 regulates EGFR–AKT–BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer

(2018) Feifei Chen et al.   Cell Death & Disease

Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment

(2017) Fubo Zhou et al.   MEDICINAL RESEARCH REVIEWS

Production of a bioactive unnatural ginsenoside by metabolically engineered yeasts based on a new UDP-glycosyltransferase from Bacillus subtilis

(2017) Huichao Liang et al.   METABOLIC ENGINEERING

Systematic and Quantitative Assessment of Hydrogen Peroxide Reactivity With Cysteines Across Human Proteomes

(2017) Ling Fu et al.   MOLECULAR & CELLULAR PROTEOMICS

Caffeic acid phenethyl ester upregulates N-myc downstream regulated gene 1 via ERK pathway to inhibit human oral cancer cell growth in vitro and in vivo

(2017) Li-Chuan Chung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

(2017) Lars Philipsen et al.   Science Signaling

Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells

(2017) Rui Li et al.   Oncotarget

B7-H3 Promotes the Migration and Invasion of Human Bladder Cancer Cells via the PI3K/Akt/STAT3 Signaling Pathway

(2017) Yuchao Li et al.   Journal of Cancer

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

(2017) Lars Philipsen et al.   Science Signaling

Effect of EGFR and p-AKT Overexpression on Chromosomal Instability in Gastric Cancer

(2016) Yuichi Hisamatsu et al.   ANNALS OF SURGICAL ONCOLOGY

Src kinases central to T-cell receptor signaling regulate TLR-activated innate immune responses from human T cells

(2016) Naveen Sharma et al.   Innate Immunity

Hepatocellular carcinoma: From diagnosis to treatment

(2016) Miral Sadaria Grandhi et al.   SURGICAL ONCOLOGY-OXFORD

Anti-EGFR monoclonal antibodies and EGFR tyrosine kinase inhibitors as combination therapy for triple-negative breast cancer

(2016) Abderrahim El Guerrab et al.   Oncotarget

The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors

(2016) Dominique Davidson et al.   Cell Reports

AKT-STAT3 Pathway as a Downstream Target of EGFR Signaling to Regulate PD-L1 Expression on NSCLC cells

(2016) Sherif Abdelhamed et al.   Journal of Cancer

Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

(2016) A. Gabrielson et al.   Cancer Immunology Research

Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells

(2016) Natasha Kapoor-Kaushik et al.   Frontiers in Immunology

Anti-cancer chalcones: Structural and molecular target perspectives

(2015) Debarshi Kar Mahapatra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Global, in situ, site-specific analysis of protein S-sulfenylation

(2015) Jing Yang et al.   Nature Protocols

Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives

(2015) Sai Fang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects (Review)

(2015) FERAH ARMUTCU et al.   Experimental and Therapeutic Medicine

The PD-1/B7-H1 Pathway Modulates the Natural Killer Cells versus Mouse Glioma Stem Cells

(2015) Bo Yuan Huang et al.   PLoS One

Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes

(2015) Huifeng Yu et al.   PLoS One

Design, Synthesis, and Biological Evaluation of (E)-3,4-Dihydroxystyryl Aralkyl Sulfones and Sulfoxides as Novel Multifunctional Neuroprotective Agents

(2014) Xianling Ning et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Synthetic Manassantin A Derivative Inhibits Hypoxia-Inducible Factor 1 and Tumor Growth

(2014) Liwei Lang et al.   PLoS One

Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation

(2013) Xianling Ning et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Caffeic Acid Phenethyl Ester Suppresses the Proliferation of Human Prostate Cancer Cells through Inhibition of p70S6K and Akt Signaling Networks

(2012) C.-P. Chuu et al.   Cancer Prevention Research

Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer

(2011) Jing Wu et al.   CANCER LETTERS

Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells

(2011) Coral O. Omene et al.   INVESTIGATIONAL NEW DRUGS

Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements

(2010) Shivanni Kummar et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacokinetics of caffeic acid phenethyl ester and its catechol-ring fluorinated derivative following intravenous administration to rats

(2009) Xinyu Wang et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Inhibitory effect of the alkyl side chain of caffeic acid analogues on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages

(2008) Koji Uwai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ectopic Lymph Nodes Within Human Solid Tumors

(2008) Domenico Coppola et al.   JOURNAL OF CLINICAL ONCOLOGY