Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives

Structure-Based Rational Design of Prodrugs To Enable Their Combination with Polymeric Nanoparticle Delivery Platforms for Enhanced Antitumor Efficacy

(2014) Hangxiang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

20(S)-Protopanaxadiol Induces Human Breast Cancer MCF-7 Apoptosis through a Caspase-Mediated Pathway

(2014) Hong Zhang et al.   Asian Pacific Journal of Cancer Prevention

Protein kinase C involvement in cell cycle modulation

(2014) Alessandro Poli et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Coumarin hybrids as novel therapeutic agents

(2014) Sonali Sandhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Induction of macrophage cell-cycle arrest and apoptosis by humic acid

(2014) Hsin-Ling Yang et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Anticancer activity of new coumarin substituted hydrazide–hydrazone derivatives

(2014) Tamer Nasr et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel building blocks of benzosuberone bearing coumarin moieties and their evaluation as potential anticancer agents

(2014) Bandi Yadagiri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, structure–activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents

(2014) Mahantesha Basanagouda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Secondary Metabolites from the Endophytic Botryosphaeria dothidea of Melia azedarach and Their Antifungal, Antibacterial, Antioxidant, and Cytotoxic Activities

(2014) Jian Xiao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents

(2014) Mei-Juan Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combination of Small Molecule Prodrug and Nanodrug Delivery: Amphiphilic Drug–Drug Conjugate for Cancer Therapy

(2014) Ping Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and synthesis of a novel series of potent, selective inhibitors of the PI3Kα: 2-alkyl-chromeno[4,3-c]pyrazol-4(2H)-one derivatives

(2014) Yong Yin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: A review on its anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects

(2013) Mai F. Tolba et al.   IUBMB LIFE

Discovery of Bufadienolides as a Novel Class of ClC-3 Chloride Channel Activators with Antitumor Activities

(2013) Junshan Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bilirubin and Related Tetrapyrroles Inhibit Food-Borne Mutagenesis: A Mechanism for Antigenotoxic Action against a Model Epoxide

(2013) Christine Mölzer et al.   JOURNAL OF NATURAL PRODUCTS

Novel porphyrin–psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies

(2013) Dalip Kumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties

(2013) Ikumi Hyohdoh et al.   ACS Medicinal Chemistry Letters

Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3β inhibitors through virtual screening

(2012) Peng Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Heck-Matsuda Arylation as a Strategy to Access Kavalactones Isolated from Polygala sabulosa, Piper methysticum, and Analogues

(2012) Cristian Soldi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Dual Targeting of Hypoxic and Acidic Tumor Environments with a Cobalt(III) Chaperone Complex

(2012) Natsuho Yamamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular networks that regulate cancer metastasis

(2012) Daniela Spano et al.   SEMINARS IN CANCER BIOLOGY

3-Arylcoumarin Derivatives Manifest Anti-proliferative Activity through Hsp90 Inhibition

(2012) Huiping Zhao et al.   ACS Medicinal Chemistry Letters

Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells

(2011) Y. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Actin Structure and Function

(2011) Roberto Dominguez et al.   Annual Review of Biophysics

Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer

(2011) Jing Wu et al.   CANCER LETTERS

Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo–keto reductase 1B10

(2011) Midori Soda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells

(2011) Coral O. Omene et al.   INVESTIGATIONAL NEW DRUGS

Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors

(2011) Nadia Touisni et al.   JOURNAL OF MEDICINAL CHEMISTRY

14-Aminocamptothecins: Their Synthesis, Preclinical Activity, and Potential Use for Cancer Treatment

(2011) Jian-Xin Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineering an Antibiotic to Fight Cancer: Optimization of the Novobiocin Scaffold to Produce Anti-proliferative Agents

(2011) Huiping Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Initial steps of metastasis: Cell invasion and endothelial transmigration

(2011) Franziska van Zijl et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Production of anticancer polyenes through precursor-directed biosynthesis

(2011) Benjamin R. Clark et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Antitumor progression potential of caffeic acid phenethyl ester involving p75NTR in C6 glioma cells

(2010) Wea-Lung Lin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Synthesis and Biological Evaluation of Polyenylpyrrole Derivatives as Anticancer Agents Acting through Caspases-Dependent Apoptosis

(2010) Zhanxiong Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues

(2010) Christopher D Gregory et al.   JOURNAL OF PATHOLOGY

Prodrugs Forming High Drug Loading Multifunctional Nanocapsules for Intracellular Cancer Drug Delivery

(2010) Youqing Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Evaluation of Noviose Replacements on Novobiocin That Manifest Antiproliferative Activity

(2010) Huiping Zhao et al.   ACS Medicinal Chemistry Letters

Apoptosis and cancer: mutations within caspase genes

(2009) S Ghavami et al.   JOURNAL OF MEDICAL GENETICS

Semisynthesis, Biological Activity, and Molecular Modeling Studies of C-Ring-Modified Camptothecins†

(2009) Cristian Samorì et al.   JOURNAL OF MEDICINAL CHEMISTRY

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Natural and synthetic 2H-pyran-2-ones and their versatility in organic synthesis

(2009) Atul Goel et al.   TETRAHEDRON

Mediation, Modulation, and Consequences of Membrane-Cytoskeleton Interactions

(2008) Gary J. Doherty et al.   Annual Review of Biophysics

Benzyl Ether-Linked Glucuronide Derivative of 10-Hydroxycamptothecin Designed for Selective Camptothecin-Based Anticancer Therapy

(2008) Yu-Ling Leu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reorganisation of the dendritic actin network during cancer cell migration and invasion

(2007) Danijela Vignjevic et al.   SEMINARS IN CANCER BIOLOGY