Potent human dihydroorotate dehydrogenase inhibitory activity of new quinoline-4-carboxylic acids derived from phenolic aldehydes: Synthesis, cytotoxicity, lipophilicity and molecular docking studies

The Dark Side of Fluorine

(2019) Yue Pan   ACS Medicinal Chemistry Letters

Dihydroorotate dehydrogenase inhibitors in anti-infective drug research

(2019) Donatella Boschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

(2018) Stefano Sainas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase

(2018) Joseph T. Madak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy

(2018) Marco L. Lolli et al.   Recent Patents on Anti-Cancer Drug Discovery

The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia

(2018) David B. Sykes   EXPERT OPINION ON THERAPEUTIC TARGETS

Reducing the Lipophilicity of Perfluoroalkyl Groups by CF2–F/CF2–Me or CF3/CH3 Exchange

(2018) Benjamin Jeffries et al.   JOURNAL OF MEDICINAL CHEMISTRY

Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer

(2018) Joseph T. Madak et al.   PHARMACOLOGY & THERAPEUTICS

Dihydroorotate dehydrogenase: A drug target for the development of antimalarials

(2017) Anju Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Understanding the Molecular Determinant of Reversible Human Monoamine Oxidase B Inhibitors Containing 2H-Chromen-2-One Core: Structure-Based and Ligand-Based Derived Three-Dimensional Quantitative Structure–Activity Relationships Predictive Models

(2017) Milan Mladenović et al.   Journal of Chemical Information and Modeling

Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase

(2017) Mathura Subangari Dorasamy et al.   Journal of Cancer

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

(2016) David B. Sykes et al.   CELL

Leflunomide and teriflunomide: altering the metabolism of pyrimidines for the treatment of autoimmune diseases

(2015) Yara Dadalti Fragoso et al.   Expert Review of Clinical Pharmacology

On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses

(2013) Hélène Munier-Lehmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

SAR-Based Optimization of a 4-Quinoline Carboxylic Acid Analogue with Potent Antiviral Activity

(2013) Priyabrata Das et al.   ACS Medicinal Chemistry Letters

The influence of lipophilicity in drug discovery and design

(2012) John A Arnott et al.   Expert Opinion on Drug Discovery

Recent Developments in the Medicinal Chemistry and Therapeutic Potential of Dihydroorotate Dehydrogenase (DHODH) Inhibitors

(2011) V. K. Vyas et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

One-pot synthesis of quinoline-4-carboxylic acid derivatives in water: Ytterbium perfluorooctanoate catalyzed Doebner reaction

(2009) Li-Min Wang et al.   JOURNAL OF FLUORINE CHEMISTRY

Structure-Based Design, Synthesis, and Characterization of Inhibitors of Human andPlasmodium falciparumDihydroorotate Dehydrogenases†

(2009) Matthew Davies et al.   JOURNAL OF MEDICINAL CHEMISTRY