Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers

Design and Synthesis of some new 2,4,6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agents

(2020) Heba Abdelrasheed Allam et al.   BIOORGANIC CHEMISTRY

Inhibition of BCL2 family members increases the efficacy of copper chelation in BRAFV600E-driven melanoma

(2020) Ye-Jin Kim et al.   CANCER RESEARCH

Repurposing of chloroquine and some clinically approved antiviral drugs as effective therapeutics to prevent cellular entry and replication of coronavirus

(2020) Akinwunmi O. Adeoye et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis

(2019) Mai Maher et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Combined menin and EGFR inhibitors synergize to suppress colorectal cancer via EGFR-independent and calcium-mediated repression of SKP2 transcription

(2019) Bryson William Katona et al.   CANCER RESEARCH

Synthesis and biological evaluation of some novel thiobenzimidazole derivatives as anti-renal cancer agents through inhibition of c-MET kinase

(2019) Hany S. Ibrahim et al.   BIOORGANIC CHEMISTRY

4(3H)-Quinazolinone derivatives: Promising antibacterial drug leads

(2019) Srikanth Gatadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advancements of 4-aminoquinazoline derivatives as kinase inhibitors and their applications in medicinal chemistry

(2019) Debasis Das et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of benzensulfonamides linked to quinazoline scaffolds as novel carbonic anhydrase inhibitors

(2019) Adel S. El-Azab et al.   BIOORGANIC CHEMISTRY

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

(2019) Morena Zusso et al.   Journal of Neuroinflammation

Chemotherapy-Induced Metastasis: Molecular Mechanisms, Clinical Manifestations, Therapeutic Interventions

(2019) George S. Karagiannis et al.   CANCER RESEARCH

Synergistic effects of gefitinib and thalidomide treatment on EGFR-TKI-sensitive and -resistant NSCLC

(2019) Xiaohong Xia et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Benzothiazole derivatives as anticancer agents

(2019) Ali Irfan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Recent Development of Sulfonyl or Sulfonamide Hybrids as Potential Anticancer Agents: A Key Review

(2018) K. P. Rakesh et al.   Anti-Cancer Agents in Medicinal Chemistry

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

(2018) Barry Jutten et al.   Autophagy

Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors

(2018) Weijie Hou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Syntheses, antiviral activities and induced resistance mechanisms of novel quinazoline derivatives containing a dithioacetal moiety

(2018) Dandan Xie et al.   BIOORGANIC CHEMISTRY

Design, synthesis and evaluation of novel sulfonamides as potential anticancer agents

(2018) Maryna V. Kachaeva et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

An overview of quinazolines: Pharmacological significance and recent developments

(2018) V. Alagarsamy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors

(2018) Hany A.M. El-Sherief et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and characterization of curcumin-sulfonamide hybrids: Biological evaluation and molecular docking studies

(2018) Govindharasu Banuppriya et al.   JOURNAL OF MOLECULAR STRUCTURE

Biologically active quinoline and quinazoline alkaloids part II

(2018) Xiao-Fei Shang et al.   MEDICINAL RESEARCH REVIEWS

Discovery of new quinazoline derivatives as irreversible dual EGFR/HER2 inhibitors and their anticancer activities – Part 1

(2018) Debasis Das et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2

(2017) Hai-Qi Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel morpholin-3-one fused quinazoline derivatives as EGFR tyrosine kinase inhibitors

(2016) Xuemei Qin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potential of N-aryl(benzyl,heteryl)-2-(tetrazolo[1,5-c]quinazolin-5-ylthio)acetamides as anticancer and antimicrobial agents

(2016) Oleksii M. Antypenko et al.   Arabian Journal of Chemistry

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

(2015) Douglas E. V. Pires et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action

(2015) Anna Mrozek-Wilczkiewicz et al.   PLoS One

Design, Synthesis and Antiproliferative Activity of Novel 2-Substituted-4-amino-6-halogenquinolines

(2012) Nan Jiang et al.   MOLECULES

Sulfur and selenium derivatives of quinazoline and pyrido[2,3-d]pyrimidine: Synthesis and study of their potential cytotoxic activity in vitro

(2011) Esther Moreno et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues

(2009) Josef Jampilek et al.   MOLECULES

Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase

(2008) Khaled Abouzid et al.   BIOORGANIC & MEDICINAL CHEMISTRY