Kupffer cell release of platelet activating factor drives dose limiting toxicities of nucleic acid nanocarriers

Genetically Encoded Split-Luciferase Biosensors to Measure Endosome Disruption Rapidly in Live Cells

(2020) Kameron V. Kilchrist et al.   ACS Sensors

The current state and future directions of RNAi-based therapeutics

(2019) Ryan L. Setten et al.   NATURE REVIEWS DRUG DISCOVERY

Unintended effects of drug carriers: Big issues of small particles

(2018) Hamideh Parhiz et al.   ADVANCED DRUG DELIVERY REVIEWS

An efficient method to isolate Kupffer cells eliminating endothelial cell contamination and selective bias

(2018) Ruairi W. Lynch et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes

(2018) Meredith A. Jackson et al.   BIOMATERIALS

Polyplex Evolution: Understanding Biology, Optimizing Performance

(2017) Arnaldur Hall et al.   MOLECULAR THERAPY

Effect of removing Kupffer cells on nanoparticle tumor delivery

(2017) Anthony J. Tavares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epinephrine inhibits vascular hyperpermeability during platelet-activating factor- or ovalbumin-induced anaphylaxis

(2017) Xiang Ma et al.   RSC Advances

Hydrophobic interactions between polymeric carrier and palmitic acid-conjugated siRNA improve PEGylated polyplex stability and enhance in vivo pharmacokinetics and tumor gene silencing

(2016) Samantha M. Sarett et al.   BIOMATERIALS

Action of Nanoparticles on Platelet Activation and Plasmatic Coagulation

(2016) Eleonore Fröhlich   CURRENT MEDICINAL CHEMISTRY

Complement Propriety and Conspiracy in Nanomedicine: Perspective and a Hypothesis

(2016) Seyed Moein Moghimi   Nucleic Acid Therapeutics

Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake

(2015) Beatriz Pelaz et al.   ACS Nano

siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer

(2015) Y. Yamamoto et al.   CLINICAL CANCER RESEARCH

Safety of Nanoparticles in Medicine

(2015) Joy Wolfram et al.   CURRENT DRUG TARGETS

Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis

(2015) Parwinder Gill et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection

(2015) Christopher B. Hergott et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy

(2014) Michelle N. Messmer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Zwitteration: Coating Surfaces with Zwitterionic Functionality to Reduce Nonspecific Adsorption

(2014) Joseph B. Schlenoff   LANGMUIR

Inflammasome-independent IL-1  mediates autoinflammatory disease in Pstpip2-deficient mice

(2014) S. L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

(2014) J. E. Zuckerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo

(2013) Christopher E. Nelson et al.   ACS Nano

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background

(2013) Stephen W. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers

(2011) Olivia M. Merkel et al.   BIOMATERIALS

The Role of Endosomal Escape and Mitogen-Activated Protein Kinases in Adenoviral Activation of the Innate Immune Response

(2011) Jeffrey S. Smith et al.   PLoS One

Cancer-induced Expansion and Activation of CD11b+Gr-1+ Cells Predispose Mice to Adenoviral-triggered Anaphylactoid-type Reactions

(2009) Kalyan Pande et al.   MOLECULAR THERAPY

Induction of Shock After Intravenous Injection of Adenovirus Vectors: A Critical Role for Platelet-activating Factor

(2009) Zhili Xu et al.   MOLECULAR THERAPY

Thematic Review Series: Glycerolipids.Phosphatidylcholine and choline homeostasis

(2008) Zhaoyu Li et al.   JOURNAL OF LIPID RESEARCH

Platelet-Activating Factor, PAF Acetylhydrolase, and Severe Anaphylaxis

(2008) Peter Vadas et al.   NEW ENGLAND JOURNAL OF MEDICINE