Heme biosynthesis in prokaryotes

Biosynthesis of the modified tetrapyrroles—the pigments of life

(2020) Donald A. Bryant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hemoglobins in the legume‐rhizobium symbiosis

(2020) Estíbaliz Larrainzar et al.   NEW PHYTOLOGIST

Actinobacterial Coproheme Decarboxylases Use Histidine as a Distal Base to Promote Compound I Formation

(2020) Hanna Michlits et al.   ACS Catalysis

Heme biosynthesis and the porphyrias

(2019) John D. Phillips   MOLECULAR GENETICS AND METABOLISM

Control of Metabolite Flux during the Final Steps of Heme b Biosynthesis in Gram-Positive Bacteria

(2019) Arianna I. Celis et al.   BIOCHEMISTRY

The hydrogen bonding network of coproheme in coproheme decarboxylase from Listeria monocytogenes: Effect on structure and catalysis

(2019) Lisa Milazzo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Crystal Structure of Dihydro-Heme d1 Dehydrogenase NirN from Pseudomonas aeruginosa Reveals Amino Acid Residues Essential for Catalysis

(2019) Thomas Klünemann et al.   JOURNAL OF MOLECULAR BIOLOGY

5-Aminolevulinate synthase catalysis: The catcher in heme biosynthesis

(2019) Bosko M. Stojanovski et al.   MOLECULAR GENETICS AND METABOLISM

Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme b

(2019) Lisa Milazzo et al.   ACS Catalysis

Staphylococcus aureus Coproporphyrinogen III Oxidase Is Required for Aerobic and Anaerobic Heme Synthesis

(2019) Jacob E. Choby et al.   mSphere

Making and breaking heme

(2019) Arianna I. Celis et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Crystal structures and calorimetry reveal catalytically relevant binding mode of coproporphyrin and coproheme in coproporphyrin ferrochelatase

(2019) Stefan Hofbauer et al.   FEBS Journal

Coproheme decarboxylases - Phylogenetic prediction versus biochemical experiments

(2018) Vera Pfanzagl et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Insights into the Active Site of Coproheme Decarboxylase from Listeria monocytogenes

(2018) Lisa Milazzo et al.   BIOCHEMISTRY

Decarboxylation involving a ferryl, propionate, and a tyrosyl group in a radical relay yields hemeb

(2018) Bennett R. Streit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cyanobacterial protoporphyrinogen oxidase HemJ is a newb-type heme protein functionally coupled with coproporphyrinogen III oxidase

(2018) Petra Skotnicová et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Radical SAM enzyme NirJ catalyzes the removal of two propionate side chains during heme d 1 biosynthesis

(2017) Linda Boss et al.   FEBS Journal

Structure-Based Mechanism for Oxidative Decarboxylation Reactions Mediated by Amino Acids and Heme Propionates in Coproheme Decarboxylase (HemQ)

(2017) Arianna I. Celis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product

(2017) Harry A. Dailey et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Elucidation of the biosynthesis of the methane catalyst coenzyme F430

(2017) Simon J. Moore et al.   NATURE

Bacterial Heme-Based Sensors of Nitric Oxide

(2017) Dominique E. Williams et al.   ANTIOXIDANTS & REDOX SIGNALING

The Remarkable Character of Porphobilinogen Synthase

(2016) Eileen K. Jaffe   ACCOUNTS OF CHEMICAL RESEARCH

The HemQ coprohaem decarboxylase generates reactive oxygen species: implications for the evolution of classical haem biosynthesis

(2016) C. Hobbs et al.   BIOCHEMICAL JOURNAL

Reactions of Ferrous Coproheme Decarboxylase (HemQ) with O2 and H2O2 Yield Ferric Heme b

(2016) Bennett R. Streit et al.   BIOCHEMISTRY

Hydrogen peroxide-mediated conversion of coproheme to hemebby HemQ-lessons from the first crystal structure and kinetic studies

(2016) Stefan Hofbauer et al.   FEBS Journal

Structure of a bd oxidase indicates similar mechanisms for membrane-integrated oxygen reductases

(2016) Schara Safarian et al.   SCIENCE

The auxiliary [4Fe–4S] cluster of the Radical SAM heme synthase from Methanosarcina barkeri is involved in electron transfer

(2016) Melanie Kühner et al.   Chemical Science

Biological Significance and Applications of Heme c Proteins and Peptides

(2015) Jesse G. Kleingardner et al.   ACCOUNTS OF CHEMICAL RESEARCH

HemQ: An iron-coproporphyrin oxidative decarboxylase for protoheme synthesis in Firmicutes and Actinobacteria

(2015) Harry A. Dailey et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Unusual Peroxide-Dependent, Heme-Transforming Reaction Catalyzed by HemQ

(2015) Arianna I. Celis et al.   BIOCHEMISTRY

Staphylococcus aureushaem biosynthesis: characterisation of the enzymes involved in final steps of the pathway

(2015) Susana A. L. Lobo et al.   MOLECULAR MICROBIOLOGY

Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin

(2015) Harry A. Dailey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterisation of Desulfovibrio vulgaris haem b synthase, a radical SAM family member

(2014) Susana A.L. Lobo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Recent advances in the biosynthesis of modified tetrapyrroles: the discovery of an alternative pathway for the formation of heme and heme d 1

(2014) Shilpa Bali et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular Phylogeny and Intricate Evolutionary History of the Three Isofunctional Enzymes Involved in the Oxidation of Protoporphyrinogen IX

(2014) Koichi Kobayashi et al.   Genome Biology and Evolution

NirN Protein fromPseudomonas aeruginosais a Novel Electron-bifurcating Dehydrogenase Catalyzing the Last Step of Hemed1Biosynthesis

(2014) Julia Adamczack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Crystal Structure of Siroheme Decarboxylase in Complex with Iron-Uroporphyrin III Reveals Two Essential Histidine Residues

(2014) Kristin Haufschildt et al.   JOURNAL OF MOLECULAR BIOLOGY

The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway

(2014) David J. Palmer et al.   MOLECULAR MICROBIOLOGY

Identification and characterization of the ‘missing’ terminal enzyme for siroheme biosynthesis in α-proteobacteria

(2014) Shilpa Bali et al.   MOLECULAR MICROBIOLOGY

The Alternative Route to Heme in the Methanogenic ArchaeonMethanosarcina barkeri

(2014) Melanie Kühner et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Maturation of the cytochromecd1nitrite reductase NirS fromPseudomonas aeruginosarequires transient interactions between the three proteins NirS, NirN and NirF

(2013) Tristan Nicke et al.   BIOSCIENCE REPORTS

Cytochromecassembly

(2013) Despoina A. I. Mavridou et al.   IUBMB LIFE

Cytochrome cd1 Nitrite Reductase NirS Is Involved in Anaerobic Magnetite Biomineralization in Magnetospirillum gryphiswaldense and Requires NirN for Proper d1 Heme Assembly

(2013) Y. Li et al.   JOURNAL OF BACTERIOLOGY

The Chlorite Dismutase (HemQ) fromStaphylococcus aureusHas a Redox-sensitive Heme and Is Associated with the Small Colony Variant Phenotype

(2013) Jeffrey A. Mayfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Environmental Heme-Based Sensor Proteins: Implications for Understanding Bacterial Pathogenesis

(2012) Aisha Farhana et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme A biosynthesis

(2012) Lars Hederstedt   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

One ring to rule them all: Trafficking of heme and heme synthesis intermediates in the metazoans

(2012) Iqbal Hamza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Discovery of a Gene Involved in a Third Bacterial Protoporphyrinogen Oxidase Activity through Comparative Genomic Analysis and Functional Complementation

(2011) Tye O. Boynton et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The cytochrome bd respiratory oxygen reductases

(2011) Vitaliy B. Borisov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Crystal Structure of the Hemed1Biosynthesis Enzyme NirE in Complex with Its Substrate Reveals New Insights into the Catalytic Mechanism ofS-Adenosyl-l-methionine-dependent Uroporphyrinogen III Methyltransferases

(2011) Sonja Storbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular hijacking of siroheme for the synthesis of heme and d1 heme

(2011) S. Bali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NirJ, a radical SAM family member of thed1heme biogenesis cluster

(2010) Amanda A. Brindley et al.   FEBS LETTERS

Discovery and Characterization of HemQ

(2010) Tamara A. Dailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of Bacillus subtilis ferrochelatase

(2010) Mattias D. Hansson et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Identification of a gene essential for protoporphyrinogen IX oxidase activity in the cyanobacterium Synechocystis sp. PCC6803

(2010) K. Kato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme biosynthesis is coupled to electron transport chains for energy generation

(2010) K. Mobius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of enzymes in heme biosynthesis

(2010) Gunhild Layer et al.   PROTEIN SCIENCE

A Novel Pathway for the Biosynthesis of Heme inArchaea: Genome-Based Bioinformatic Predictions and Experimental Evidence

(2010) Sonja Storbeck et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Functional characterization of the early steps of tetrapyrrole biosynthesis and modification inDesulfovibrio vulgarisHildenborough

(2009) Susana A. L. Lobo et al.   BIOCHEMICAL JOURNAL

Identification ofEscherichia coliHemG as a Novel, Menadione-Dependent Flavodoxin with Protoporphyrinogen Oxidase Activity

(2009) Tye O. Boynton et al.   BIOCHEMISTRY

d1 haem biogenesis - assessing the roles of three nir gene products

(2009) Richard S. Zajicek et al.   FEBS Journal

The Pseudomonas aeruginosa nirE gene encodes the S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase required for heme d1 biosynthesis

(2009) Sonja Storbeck et al.   FEBS Journal

Structural insight into unique properties of protoporphyrinogen oxidase from Bacillus subtilis

(2009) Xiaohong Qin et al.   JOURNAL OF STRUCTURAL BIOLOGY

Porphyrin Binding and Distortion and Substrate Specificity in the Ferrochelatase Reaction: The Role of Active Site Residues

(2008) Tobias Karlberg et al.   JOURNAL OF MOLECULAR BIOLOGY

Genome-Based Analysis of Heme Biosynthesis and Uptake in Prokaryotic Systems

(2008) Gabriele Cavallaro et al.   JOURNAL OF PROTEOME RESEARCH