Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Mengsha Wei, Liping Huang, Qin Li, Xinyi Qiao, Ziming Zhao, Jie Yin, Aimin Fu, Jieru Guo, Xincai Hao, Lianghu Gu, Jianping Wang, Chunmei Chen, Hucheng Zhu, Yonghui Zhang
Summary: Five aromatic ergosterols with unique ring systems, named spectasterols A-E (1-5), were isolated from Aspergillus spectabilis. Compound 3 demonstrated cytotoxic activity and anti-inflammatory effects, inducing cell cycle arrest and apoptosis in HL60 cells, and inhibiting COX-2 levels and NF-kappa B p65 nuclear translocation.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Multidisciplinary Sciences
Fraser D. Russell, Jeanne C. Visagie, Jamie L. Noll
Summary: Endotoxin in honey can stimulate IL-6 secretion and activate TLR4 signaling.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Sera Sermet, Jinpeng Li, Anthony Bach, Robert B. Crawford, Norbert E. Kaminski
Summary: This study evaluated the impact of CBD on human primary monocytes activated through Toll-like receptors (TLR). The results showed that CBD suppressed the secretion of inflammatory cytokine IL-1β by monocytes activated through most TLRs, while also significantly modulating the production of IL-6. Most other immune mediators were not affected by CBD modulation.
Review
Immunology
Toshio Hirano
Summary: IL-6 is involved in various physiological processes including immune responses and inflammation. It plays a crucial role in chronic inflammation and cytokine storms, such as seen in COVID-19. The IL-6 amplifier, involving NF-kappa B and STAT3, is a key mechanism in promoting uncontrolled inflammatory responses.
INTERNATIONAL IMMUNOLOGY
(2021)
Article
Cell Biology
Ahmed Shamloul, Gustav Steinemann, Kerrin Roos, Celine Huajia Liem, Jonathan Bernd, Thorsten Braun, Andreas Zakrzewicz, Janine Berkholz
Summary: The methyltransferase Smyd1 plays a crucial role in regulating IL-6 expression and secretion in endothelial cells by increasing NF-kappa B activity and promoting H3K4 trimethylation within the IL-6 promoter in response to LPS stimulation.
Article
Cell Biology
Xuedi Gao, Wenfang Bao, Jin Bai, Kailing Fan, Li Li, Yandong Li
Summary: UHMK1 is frequently upregulated in colorectal cancer and its high expression predicts poor prognosis. Knockdown of UHMK1 inhibits CRC cell proliferation and increases sensitivity to oxaliplatin, while overexpression of UHMK1 promotes CRC cell growth and oxaliplatin resistance. UHMK1 interacts with STAT3 and enhances its activity in regulating gene transcription, thus affecting IL6/STAT3 signaling.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Ghada S. El-Tanbouly, Rehab S. Abdelrahman
Summary: This study explored the protective mechanisms of Trans-cinnamaldehyde (TCA) on complete Freund's adjuvant (CFA)-induced arthritis. TCA can slow down the progression of arthritis and inhibit the immune/inflammatory responses via NF-kappa B modulation, with similar effects to methotrexate.
INFLAMMOPHARMACOLOGY
(2022)
Article
Immunology
Bazgha Gul, Rukhsana Anwar, Mohammad Saleem, Afifa Noor, Muhammad Ihsan Ullah
Summary: The current study evaluated the anti-arthritic activity of n-hexane and aqueous extracts of Cassia absus seeds. The extracts showed significant inhibition of paw edema and reduction in paw size and joint diameter. The extracts also improved the levels of inflammatory and oxidative biomarkers. Polymerase chain reaction investigation revealed the modulation of various inflammatory factors by the extracts. In conclusion, Cassia absus can effectively alleviate arthritis symptoms by modulating oxidative and inflammatory biomarkers.
INFLAMMOPHARMACOLOGY
(2023)
Article
Cell Biology
Qi-qi Liu, Wei-wei Wu, Jian Yang, Rui-bin Wang, Ling-ling Yuan, Pei-zhao Peng, Mao-yun Zeng, Ke Yu
Summary: In this study, the GP130-targeting molecule LMT-28 was found to effectively reduce lipopolysaccharide-induced bone resorption around implants in diabetic rats. LMT-28 downregulated the expression of RANKL and decreased osteoclast activity through the JAK2/STAT3 signaling pathway. These findings highlight the potential of LMT-28 as a therapeutic agent for peri-implantitis in diabetic patients.
MEDIATORS OF INFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Denglu Long, Meng Liu, Haiyang Li, Jinhuan Song, Xiaohua Jiang, Guang Wang, Xuesong Yang
Summary: The study identified that the suppression of neurogenesis induced by dysbacteriosis-derived LPS could be significantly reversed through fecal microbiota transplantation. This suggests that gut dysbacteriosis impairs embryonic neurogenesis. The NF-kappa B/IL-6 pathway may be one of the main factors triggering the downstream signaling cascade.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Guoli Wu, Guangying Qi, Yu Liu, Jinfeng Gan, Chichu Xie, Qi Wu, Wei Cui, Chunhua Wang, Zhaoyi Wang
Summary: This study found that calycosin inhibits IL-6 production in macrophages by enhancing ER-alpha 36 expression and its interaction with p65, attenuating its function as an inducer of IL-6 transcription.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Biochemistry & Molecular Biology
Xue Rong, Jie Xu, Yang Jiang, Feng Li, Yilun Chen, Q. Ping Dou, Dapeng Li
Summary: Nobiletin enhances autophagy through activating the IL-6/STAT3/FOXO3a pathway in macrophage cells, leading to suppression of inflammatory response.
Article
Cell Biology
Kristina Riegel, Hajime Yurugi, Janine Schloeder, Helmut Jonuleit, Manuel Kaulich, Friederike Kirschner, Danielle Arnold-Schild, Stefan Tenzer, Hansjorg Schild, Krishnaraj Rajalingam
Summary: Tumors suppress antitumor immune responses by secreting IL-6, which inhibits the production of IL-12p70 in dendritic cells. The classical mitogen-activated protein kinase ERK5/MAPK7 is essential for IL-6 production in tumor cells, suggesting a potential target for enhancing antitumor immune responses.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Caoimhe M. K. Lynch, Caitlin S. M. Cowan, Thomaz F. S. Bastiaanssen, Gerard M. Moloney, Nigel Theune, Marcel van de Wouw, Eva Florensa Zanuy, Ana Paula Ventura-Silva, Martin G. Codagnone, Francisca Villalobos-Manriquez, Matilde Segalla, Fatma Koc, Catherine Stanton, Paul Ross, Timothy G. Dinan, Gerard Clarke, John F. Cryan
Summary: Numerous studies have shown that the gut microbiota plays a crucial role in neurodevelopment and behavior. Early-life exposure to antibiotics has been associated with increased risk of immune and metabolic diseases. Targeted antibiotic-induced disruption of the microbiota during critical developmental periods has enduring effects on physiology and behavior. This study demonstrates that microbiota disruption during early life alters the structure and function of the caecal microbiome, as well as immune cells and neurophysiology in adolescence. However, the effects on behavior are limited and subtle, suggesting the importance of the gut microbiota during critical windows of development.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Ekaterina Noskova, Roberto Fernandez, Javier Garcia, Eneko Ochoa, Celtia Dominguez-Fernandez, Albert Adell, Antonio Laso, Maria Fe Andres, Azucena Gonzalez-Coloma, Egoitz Astigarraga, Gabriel Barreda-Gomez
Summary: The development of high-CBD and low-THC Cannabis sativa strains is an important area of research for medical and recreational purposes. Mitochondria play a significant role in the clinical effects of cannabinoids, and cannabinoids can modulate mitochondrial activity through various mechanisms. This study aimed to identify strains with a safer profile by investigating the effects of Cannabis sativa extracts on the activity of cytochrome c oxidase, a mitochondrial enzyme involved in cellular respiration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
David Martin-Hernandez, Maria Martinez, Javier Robledo-Montana, Marina Munoz-Lopez, Leire Virto, Nagore Ambrosio, Maria Jose Marin, Eduardo Montero, David Herrera, Mariano Sanz, Juan C. Leza, Elena Figuero, Borja Garcia-Bueno
Summary: This study investigated the potential mechanisms underlying the association between periodontitis and depression. Using a rat model, the study found that neuroinflammation (microglia, blood-brain barrier permeability, and sphingosine-1-phosphate pathways) may play a role in this association. The findings showed that the combined effects of periodontitis and chronic mild stress increased neuroinflammation and disrupted the blood-brain barrier. The study also identified differential regulation of enzymes and receptors in the sphingosine-1-phosphate pathway. These findings contribute to our understanding of the relationship between periodontitis and depression.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaiza Garro-Aguilar, Roberto Fernandez, Silvia Calero, Ekaterina Noskova, Marina Gulak, Miguel de la Fuente, Albert Adell, Edurne Simon, Urko Muzquiz, Diego Rodriguez-Pinon, Egoitz Astigarraga, Gabriel Barreda-Gomez
Summary: Producers of milk and dairy products are facing the challenge of meeting European society's demand for animal welfare. Measures have been taken to improve animal welfare conditions and evaluation systems have been developed, but more sensitive technologies are needed to monitor animal health. Lipid species have been identified as potential biomarkers of health status in dairy cows, and specific lipid profiles have been found depending on the origin and freedom of the animals on the farm.
Article
Clinical Neurology
Silvia Breviario, Julia Senserrich, Eva Florensa-Zanuy, Emilio Garro-Martinez, Alvaro Diaz, Elena Castro, Angel Pazos, Fuencisla Pilar-Cuellar
Summary: The study found that the activity and protein expression of MMP-9 are significantly elevated in brain areas relevant to depression, while nectin-3 levels are lower in these areas. The immobility time in the tail suspension test is positively correlated with cortical MMP-9 activity and negatively correlated with nectin-3 levels. These findings support the role of MMP-9 in the pathophysiology of depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Viktor Burstrom, Richard agren, Nibal Betari, Marta Valle-Leon, Emilio Garro-Martinez, Francisco Ciruela, Kristoffer Sahlholm
Summary: In this study, a novel nanoluciferase complementation assay was used to investigate the dopamine-induced recruitment of beta-arrestin2 (beta arr2) and G protein-coupled receptor kinase-2 (GRK2) to the D4 receptor. The desensitization of D4 receptor-evoked G protein-coupled inward rectifier potassium (GIRK) current responses was also studied. The results showed that coexpression of GRK2 enhanced the potency of dopamine to induce beta arr2 recruitment to the D4 receptor and accelerated the rate of desensitization of D4 receptor-evoked GIRK responses.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Psychiatry
J. M. Lopez-Villatoro, M. Diaz-Marsa, A. de la Torre-Luque, K. S. MacDowell, C. Prittwitz, J. C. Leza, J. L. Carrasco
Summary: This study aimed to identify clusters of BPD patients based on inflammatory/oxidative biomarker profiles and investigate their association with phenotypic features. Two clusters were identified: Cluster 1 patients had higher levels of antioxidant and anti-inflammatory biomarkers, longer disease duration, milder anxiety symptoms, and lower prescription of antipsychotic drugs compared to Cluster 2 patients.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Maria Hidalgo-Figueroa, Alejandro Salazar, Cristina Romero-Lopez-Alberca, Karina S. MacDowell, Borja Garcia-Bueno, Miquel Bioque, Miquel Bernardo, Mara Parellada, Ana Gonzalez-Pinto, M. Paz Garcia-Portilla, Antonio Lobo, Roberto Rodriguez-Jimenez, Esther Berrocoso, Juan C. Leza, FLAMM-PEPs Study
Summary: This study found that prolactin levels decreased in FEP patients during follow-up, and patients treated with risperidone or paliperidone had higher prolactin levels than those treated with other antipsychotic agents. However, no changes in oxytocin and homocysteine plasma levels were observed between baseline and follow-up. Prolactin and homocysteine levels were associated with the severity of psychotic symptoms in male FEP patients, but not in females. These molecules, along with oxytocin, may also be related to cognitive domains in FEP patients.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
David Martin-Hernandez, Marina Munoz-Lopez, Hiram Tendilla-Beltran, Javier R. Caso, Borja Garcia-Bueno, Luis Menchen, Juan C. Leza
Summary: Extensive research has shown the importance of immune alterations and dysfunctional biological barriers in psychiatric disorders. The leaky gut phenomenon, closely related to the brain and intestinal barriers, may contribute to inflammation in these conditions. Drugs based on sphingosine-1-phosphate (S1P), such as fingolimod and ozanimod, have been approved for multiple sclerosis and ulcerative colitis treatment, sparking a debate for their use in psychiatry. This review focuses on the molecular mechanisms of S1P in modulating the immune system and brain/intestinal barriers, aiming to uncover innovative therapies for psychiatric diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Clinical
Ana Izquierdo, Maria Cabello, Itziar Leal, Iosune Torio, Jose L. M. Madrigal, Karina S. MacDowell, Roberto Rodriguez-Jimenez, David Rentero, Angela Ibanez, Miriam Ayora, Covadonga M. Diaz-Caneja, Renzo Abregii-Crespo, Blanca Mellor-Marsa, Marina Diaz-Marsa, Norberto Malpica, Maria-Fe Bravo-Ortiz, Enrique Baca-Garcia, Celso Arango, Jose Luis Ayuso-Mateos, AGES-CM Grp
Summary: This study aimed to assess whether neighborhood vulnerability and risk of social exclusion could predict functional outcomes in patients with first episode of psychosis. The results showed that patients with first episode of psychosis are more vulnerable to the effects of neighborhood-level characteristics, and higher neighborhood vulnerability is related to greater functional disability in these patients.
JOURNAL OF CLINICAL PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Francisco Ruiz-Guerrero, Andres Gomez del Barrio, Alejandro de la Torre-Luque, Wala Ayad-Ahmed, Luis Beato-Fernandez, Filomena Polo Montes, Magdalena Leon Velasco, Karina S. Macdowell, Juan C. Leza, Jose Luis Carrasco, Marina Diaz-Marsa
Summary: The study suggests that there may be common inflammatory pathways between borderline personality disorder and eating disorders, with associations to childhood trauma and clinical features. These findings highlight the importance of further research in this area.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)