Emodin ameliorates tubulointerstitial fibrosis in obstructed kidneys by inhibiting EZH2

Reactive Oxygen Species and Redox Signaling in Chronic Kidney Disease

(2020) Maria V. Irazabal et al.   Cells

Polycomb Repressive Complex 2 Proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Gene Expression at Promoter Regions in Euchromatin in Mice

(2019) Jessica Mae Grindheim et al.   GASTROENTEROLOGY

Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial–mesenchymal transition and attenuates renal fibrosis

(2018) Xiaoxu Zhou et al.   FASEB JOURNAL

Emodin suppresses activation of hepatic stellate cells through p38 mitogen-activated protein kinase and Smad signaling pathways in vitro

(2018) Xiaoli Wang et al.   PHYTOTHERAPY RESEARCH

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Hmwe Hmwe Kyu et al.   LANCET

Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2

(2017) Libin Ma et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Emodin suppresses TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells through Notch signaling pathway

(2017) Rundi Gao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility

(2017) Erine H. Budi et al.   TRENDS IN CELL BIOLOGY

Emodin ameliorates cisplatin-induced apoptosis of rat renal tubular cells in vitro by activating autophagy

(2016) Hong Liu et al.   ACTA PHARMACOLOGICA SINICA

Ezh2 restricts the smooth muscle lineage during mouse lung mesothelial development

(2016) Melinda Snitow et al.   DEVELOPMENT

Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression

(2015) X. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The study on the material basis and the mechanism for anti-renal interstitial fibrosis efficacy of rhubarb through integration of metabonomics and network pharmacology

(2015) Zheng Xiang et al.   Molecular BioSystems

Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor α-mediated transforming growth factor-β1/Smad signaling pathway

(2014) Dal Kim et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Renal epithelial injury and fibrosis

(2013) Brigitte Kaissling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

Emodin ameliorates high-glucose induced mesangial p38 over-activation and hypocontractility via activation of PPARγ

(2009) Yi Liu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose

(2009) Xuejuan Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

In vitro anti-fibrotic activities of herbal compounds and herbs

(2009) Qin Hu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

(2008) Manching Ku et al.   PLoS Genetics