Exploring IL-17 in spondyloarthritis for development of novel treatments and biomarkers

Autoantibodies in Spondyloarthritis, Focusing on Anti-CD74 Antibodies

(2019) Yuan Liu et al.   Frontiers in Immunology

The IL-17 Family of Cytokines in Health and Disease

(2019) Mandy J. McGeachy et al.   IMMUNITY

Structural progression in axial spondyloarthritis

(2019) Krystel Aouad et al.   JOINT BONE SPINE

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

(2019) Dennis G McGonagle et al.   ANNALS OF THE RHEUMATIC DISEASES

TRAF Regulation of IL-17 Cytokine Signaling

(2019) Shadi Swaidani et al.   Frontiers in Immunology

Implication of IL-17 in Bone Loss and Structural Damage in Inflammatory Rheumatic Diseases

(2019) Benoit Le Goff et al.   MEDIATORS OF INFLAMMATION

IL‐17 alters the mesenchymal stem cell niche towards osteogenesis in cooperation with osteocytes

(2019) Chongshan Liao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metabolites of type I, II, III, and IV collagen may serve as markers of disease activity in axial spondyloarthritis

(2019) Markéta Hušáková et al.   Scientific Reports

Antibodies to watch in 2020

(2019) Hélène Kaplon et al.   mAbs

Altered Bone Remodeling in Psoriatic Disease: New Insights and Future Directions

(2018) Ananta Paine et al.   CALCIFIED TISSUE INTERNATIONAL

Complex role of IL-23R polymorphisms on ankylosing spondylitis: a meta-analysis

(2018) Linqing Zhong et al.   Expert Review of Clinical Immunology

Circulating microRNAs as potential biomarkers of disease activity and structural damage in ankylosing spondylitis patients

(2018) Carlos Perez-Sanchez et al.   HUMAN MOLECULAR GENETICS

Axial disease in psoriatic arthritis and ankylosing spondylitis: a critical comparison

(2018) Joy Feld et al.   Nature Reviews Rheumatology

OUP accepted manuscript

(2018)   RHEUMATOLOGY

Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study

(2018) Dominique Baeten et al.   ANNALS OF THE RHEUMATIC DISEASES

Evolving concepts of new bone formation in axial spondyloarthritis: Insights from animal models and human studies

(2018) Rik J. Lories et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Effects of the IL-23–IL-17 pathway on bone in spondyloarthritis

(2018) Ellen M. Gravallese et al.   Nature Reviews Rheumatology

Three Multicenter, Randomized, Double-Blind, Placebo-Controlled Studies Evaluating the Efficacy and Safety of Ustekinumab in Axial Spondyloarthritis

(2018) Atul Deodhar et al.   Arthritis & Rheumatology

Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with biological disease-modifying anti-rheumatic drugs (COAST-V): 16 week results of a phase 3 randomised, double-blind, active-controlled and placebo-controlled trial

(2018) Désirée van der Heijde et al.   LANCET

Efficacy and Safety of Ixekizumab in the Treatment of Radiographic Axial Spondyloarthritis: 16 Week Results of a Phase 3 Randomized, Double-Blind, Placebo Controlled Trial in Patients with Prior Inadequate Response or Intolerance to Tumor Necrosis Factor

(2018) Atul Deodhar et al.   Arthritis & Rheumatology

CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin

(2017) Stanley Cheuk et al.   IMMUNITY

Patient Burden of Axial Spondyloarthritis

(2017) Vibeke Strand et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week randomised, double-blind, placebo-controlled period of the SPIRIT-P2 phase 3 trial

(2017) Peter Nash et al.   LANCET

Different Modulatory Effects of IL-17, IL-22, and IL-23 on Osteoblast Differentiation

(2017) Jing-Ru Zhang et al.   MEDIATORS OF INFLAMMATION

The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping

(2017) Stephen Eyre et al.   Nature Reviews Rheumatology

Conventional Radiology in Rheumatoid Arthritis

(2017) Eva Llopis et al.   RADIOLOGIC CLINICS OF NORTH AMERICA

IL-17 Signaling: The Yin and the Yang

(2017) Nilesh Amatya et al.   TRENDS IN IMMUNOLOGY

Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic Implications

(2017) Leticia Monin et al.   Cold Spring Harbor Perspectives in Biology

Differentially expressed mRNAs, lncRNAs, and miRNAs with associated co-expression and ceRNA networks in ankylosing spondylitis

(2017) Chen Zhang et al.   Oncotarget

Macrophage Migration Inhibitory Factor Induces Inflammation and Predicts Spinal Progression in Ankylosing Spondylitis

(2017) Vidya Ranganathan et al.   Arthritis & Rheumatology

IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice

(2017) Kozo Nakai et al.   Scientific Reports

The psoriasis-associated IL-17A induces and cooperates with IL-36 cytokines to control keratinocyte differentiation and function

(2017) Carolina M. Pfaff et al.   Scientific Reports

miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis

(2016) L Chen et al.   ANNALS OF THE RHEUMATIC DISEASES

High disease activity according to the Ankylosing Spondylitis Disease Activity Score is associated with accelerated radiographic spinal progression in patients with early axial spondyloarthritis: results from the GErman SPondyloarthritis Inception Cohort

(2016) Denis Poddubnyy et al.   ANNALS OF THE RHEUMATIC DISEASES

Axial Disease in Psoriatic Arthritis study: defining the clinical and radiographic phenotype of psoriatic spondyloarthritis

(2016) Deepak R Jadon et al.   ANNALS OF THE RHEUMATIC DISEASES

Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled period of the phase III trial SPIRIT-P1

(2016) Philip J Mease et al.   ANNALS OF THE RHEUMATIC DISEASES

An update on biomarkers in axial spondyloarthritis

(2016) Klára Prajzlerová et al.   AUTOIMMUNITY REVIEWS

CRP and a biomarker of type I collagen degradation, C1M, can differentiate anti-inflammatory treatment response in ankylosing spondylitis

(2016) Anne Sofie Siebuhr et al.   Biomarkers in Medicine

Bone remodeling in psoriasis and psoriatic arthritis

(2016) Ananta Paine et al.   CURRENT OPINION IN RHEUMATOLOGY

Secukinumab for the treatment of psoriatic arthritis

(2016) Renata Baronaite Hansen et al.   Expert Review of Clinical Immunology

IL-17A plays a central role in the expression of psoriasis signature genes through the induction of IκB-ζ in keratinocytes

(2016) Ryuta Muromoto et al.   INTERNATIONAL IMMUNOLOGY

Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis

(2016) Kenneth B. Gordon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-17 inhibitors. A new era in treatment of psoriasis and other skin diseases

(2016) Agnieszka Wasilewska et al.   Postepy Dermatologii i Alergologii

Differential mechanisms of de-regulated bone formation in rheumatoid arthritis and spondyloarthritis

(2016) Steven R. Goldring   RHEUMATOLOGY

Global Prevalence of Spondyloarthritis: A Systematic Review and Meta-Regression Analysis

(2016) Carmen Stolwijk et al.   ARTHRITIS CARE & RESEARCH

IL-17-producing γδ T cells enhance bone regeneration

(2016) Takehito Ono et al.   Nature Communications

Brief Report: Secukinumab Provides Significant and Sustained Inhibition of Joint Structural Damage in a Phase III Study of Active Psoriatic Arthritis

(2016) Désirée van der Heijde et al.   Arthritis & Rheumatology

Interleukin-23-Dependent γ/δ T Cells Produce Interleukin-17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice

(2016) Annika Reinhardt et al.   Arthritis & Rheumatology

Interleukin-17 Stimulates STAT3-Mediated Endothelial Cell Activation for Neutrophil Recruitment

(2015) Shaopeng Yuan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Secukinumab: First Global Approval

(2015) Mark Sanford et al.   DRUGS

The ongoing quest for biomarkers in Ankylosing Spondylitis

(2015) Abhijeet Danve et al.   International Journal of Rheumatic Diseases

Quantitative and Qualitative Changes of Bone in Psoriasis and Psoriatic Arthritis Patients

(2015) Roland Kocijan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial

(2015) Diamant Thaçi et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2015) Iain B McInnes et al.   LANCET

Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis

(2015) Dominique Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic Arthritis

(2015) Philip J. Mease et al.   NEW ENGLAND JOURNAL OF MEDICINE

Focal bone involvement in inflammatory arthritis: the role of IL17

(2015) Maurizio Rossini et al.   RHEUMATOLOGY INTERNATIONAL

Serum Adipokine Levels in Patients With Ankylosing Spondylitis and Their Relationship to Clinical Parameters and Radiographic Spinal Progression

(2015) Uta Syrbe et al.   Arthritis & Rheumatology

Bone formation in axial spondyloarthritis

(2014) Rik J. Lories et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The classification and diagnostic criteria of ankylosing spondylitis

(2014) Siba P. Raychaudhuri et al.   JOURNAL OF AUTOIMMUNITY

IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma

(2014) C. Song et al.   JOURNAL OF IMMUNOLOGY

The IL-17A-Producing CD8 + T-Cell Population in Psoriatic Lesional Skin Comprises Mucosa-Associated Invariant T Cells and Conventional T Cells

(2014) Marcel B.M. Teunissen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Serum Soluble Bone Turnover Biomarkers in Psoriatic Arthritis and Psoriatic Spondyloarthropathy

(2014) D. R. Jadon et al.   JOURNAL OF RHEUMATOLOGY

Biomarkers of Bone Metabolism in Ankylosing Spondylitis in Relation to Osteoproliferation and Osteoporosis

(2014) E. Klingberg et al.   JOURNAL OF RHEUMATOLOGY

Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor

(2014) Leyla Didem Kozaci et al.   Modern Rheumatology

Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials

(2014) Richard G. Langley et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms

(2014) H.-L. Ha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Role of Protein Phosphatase Magnesium-Dependent 1A and Anti-Protein Phosphatase Magnesium-Dependent 1A Autoantibodies in Ankylosing Spondylitis

(2014) Yong-Gil Kim et al.   Arthritis & Rheumatology

Combined Inhibition of Tumor Necrosis Factor α and Interleukin-17 As a Therapeutic Opportunity in Rheumatoid Arthritis: Development and Characterization of a Novel Bispecific Antibody

(2014) Jens A. A. Fischer et al.   Arthritis & Rheumatology

Interleukin-23 Mediates the Intestinal Response to Microbial β-1,3-Glucan and the Development of Spondyloarthritis Pathology in SKG Mice

(2014) Helen Benham et al.   Arthritis & Rheumatology

Interleukin-17+CD8+ T Cells Are Enriched in the Joints of Patients With Psoriatic Arthritis and Correlate With Disease Activity and Joint Damage Progression

(2014) Bina Menon et al.   Arthritis & Rheumatology

Effects of Interleukin-17A on Osteogenic Differentiation of Isolated Human Mesenchymal Stem Cells

(2014) Bilal Osta et al.   Frontiers in Immunology

Ankylosing spondylitis patients with and without psoriasis do not differ in disease phenotype

(2013) Pedro Machado et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy of certolizumab pegol on signs and symptoms of axial spondyloarthritis including ankylosing spondylitis: 24-week results of a double-blind randomised placebo-controlled Phase 3 study

(2013) R Landewé et al.   ANNALS OF THE RHEUMATIC DISEASES

High prevalence of anti-CD74 antibodies specific for the HLA class II-associated invariant chain peptide (CLIP) in patients with axial spondyloarthritis: Table 1

(2013) X Baraliakos et al.   ANNALS OF THE RHEUMATIC DISEASES

Autoantibodies against CD74 in spondyloarthritis

(2013) N T Baerlecken et al.   ANNALS OF THE RHEUMATIC DISEASES

In Situ Analysis of Interleukin-23- and Interleukin-12-Positive Cells in the Spine of Patients With Ankylosing Spondylitis

(2013) Heiner Appel et al.   ARTHRITIS AND RHEUMATISM

Brief Report: Magnetic Resonance Imaging Assessment of Axial Psoriatic Arthritis: Extent of Disease Relates to HLA-B27

(2013) Concepción Castillo-Gallego et al.   ARTHRITIS AND RHEUMATISM

The role of interleukin-17 in bone metabolism and inflammatory skeletal diseases

(2013) Youngkyun Lee   BMB Reports

IL-17A Induces Pro-Inflammatory Cytokines Production in Macrophages via MAPKinases, NF-κB and AP-1

(2013) Jian Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

(2013) Adrian Cortes et al.   NATURE GENETICS

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover

(2013) A.S. Siebuhr et al.   OSTEOARTHRITIS AND CARTILAGE

Circulating Protein Fragments of Cartilage and Connective Tissue Degradation Are Diagnostic and Prognostic Markers of Rheumatoid Arthritis and Ankylosing Spondylitis

(2013) Anne C. Bay-Jensen et al.   PLoS One

Impact of Inflammation on the Osteoblast in Rheumatic Diseases

(2013) Rebecca Baum et al.   Current Osteoporosis Reports

Bone anabolic changes progress in psoriatic arthritis patients despite treatment with methotrexate or tumour necrosis factor inhibitors

(2012) Stephanie Finzel et al.   ANNALS OF THE RHEUMATIC DISEASES

Etanercept in the treatment of ankylosing spondylitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials, and the comparison of the Caucasian and Chinese population

(2012) Zhi-han Li et al.   European Journal of Orthopaedic Surgery and Traumatology

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Levels of Circulating Th17 Cells and Regulatory T Cells in Ankylosing Spondylitis Patients with an Inadequate Response to Anti−TNF-α Therapy

(2012) Li Xueyi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

IL-17 and TNF-  Sustain Neutrophil Recruitment during Inflammation through Synergistic Effects on Endothelial Activation

(2012) G. K. Griffin et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TNF Receptor-Associated Factor 4 Restricts IL-17-Mediated Pathology and Signaling Processes

(2012) J. A. Zepp et al.   JOURNAL OF IMMUNOLOGY

Association of serum interleukin-17 and interleukin-23 levels with disease activity in Chinese patients with ankylosing spondylitis

(2012) Wei-Sheng Chen et al.   Journal of the Chinese Medical Association

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells

(2012) Jonathan P Sherlock et al.   NATURE MEDICINE

Decreased Th17 and Th1 cells in the peripheral blood of patients with early non-radiographic axial spondyloarthritis: a marker of disease activity in HLA-B27+ patients

(2012) M.-B. Bautista-Caro et al.   RHEUMATOLOGY

Interleukin-17A upregulates receptor activator of NF-κB on osteoclast precursors

(2012) Iannis E Adamopoulos et al.   ARTHRITIS RESEARCH & THERAPY

Low sclerostin levels: a predictive marker of persistent inflammation in ankylosing spondylitis during anti-tumor necrosis factor therapy?

(2012) Carla GS Saad et al.   ARTHRITIS RESEARCH & THERAPY

High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis

(2011) Gisela Ruiz Heiland et al.   ANNALS OF THE RHEUMATIC DISEASES

Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis

(2011) D. Poddubnyy et al.   ANNALS OF THE RHEUMATIC DISEASES

Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and c

(2011) Susanne Juhl Pedersen et al.   ARTHRITIS AND RHEUMATISM

Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis

(2011) Troy Noordenbos et al.   ARTHRITIS AND RHEUMATISM

Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: Rationale for combination treatment during arthritis

(2011) Marije I. Koenders et al.   ARTHRITIS AND RHEUMATISM

Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive γ/δ T cells in patients with active ankylosing spondylitis

(2011) Tony J. Kenna et al.   ARTHRITIS AND RHEUMATISM

Interleukin-17A increases leptin production in human bone marrow mesenchymal stem cells

(2011) Minsoo Noh   BIOCHEMICAL PHARMACOLOGY

Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM—Increased serum CIIM in subjects with severe radiographic osteoarthritis

(2011) Anne-Christine Bay-Jensen et al.   CLINICAL BIOCHEMISTRY

Macrophages participate in IL-17-mediated inflammation

(2011) Jobert G. Barin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential Role of the Interleukin-17 Axis and Neutrophils in Resolution of Inhalational Anthrax

(2011) Kévin Garraud et al.   INFECTION AND IMMUNITY

Th17 Cells Expressing KIR3DL2+ and Responsive to HLA-B27 Homodimers Are Increased in Ankylosing Spondylitis

(2011) P. Bowness et al.   JOURNAL OF IMMUNOLOGY

Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)

(2011) Dongxu Sun et al.   NATURE IMMUNOLOGY

Ankylosing spondylitis is characterized by an increased turnover of several different metalloproteinase-derived collagen species: a cross-sectional study

(2011) Anne C. Bay-Jensen et al.   RHEUMATOLOGY INTERNATIONAL

Dickkopf-1 level is lower in patients with ankylosing spondylitis than in healthy people and is not influenced by anti-tumor necrosis factor therapy

(2011) Seong-Ryul Kwon et al.   RHEUMATOLOGY INTERNATIONAL

Analysis of IL-17+ cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response

(2011) Heiner Appel et al.   ARTHRITIS RESEARCH & THERAPY

A comparative study of periarticular bone lesions in rheumatoid arthritis and psoriatic arthritis

(2010) S. Finzel et al.   ANNALS OF THE RHEUMATIC DISEASES

Pathogenic role of IL-17 in endothelial dysfunction, a link between rheumatoid arthritis and atherosclerosis

(2010) A. Hot et al.   ANNALS OF THE RHEUMATIC DISEASES

Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production

(2010) J. P. van Hamburg et al.   ARTHRITIS AND RHEUMATISM

Increased serum IL-17 and IL-23 in the patient with ankylosing spondylitis

(2010) Yang Mei et al.   CLINICAL RHEUMATOLOGY

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

(2010) Reiko M. Onishi et al.   IMMUNOLOGY

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

(2010) John S. Cho et al.   JOURNAL OF CLINICAL INVESTIGATION

Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling

(2010) Shu Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in Psoriasis

(2010) Andrea Chiricozzi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The early disease stage in axial spondylarthritis: Results from the german spondyloarthritis inception cohort

(2009) Martin Rudwaleit et al.   ARTHRITIS AND RHEUMATISM

Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis

(2009) Heiner Appel et al.   ARTHRITIS AND RHEUMATISM

Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis

(2009) Francesco Ciccia et al.   ARTHRITIS AND RHEUMATISM

Erythrocyte sedimentation rate, C-reactive protein level, and serum amyloid A protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitis

(2009) Mirjam K. de Vries et al.   ARTHRITIS AND RHEUMATISM

IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling

(2009) H Huang et al.   CELL DEATH AND DIFFERENTIATION

Interleukin-17A and Interleukin-17F: A Tale of Two Cytokines

(2009) Patricia J. Dubin et al.   IMMUNITY

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

(2009) Harumichi Ishigame et al.   IMMUNITY

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides

(2008) Camilla Jandus et al.   ARTHRITIS AND RHEUMATISM

Critical appraisal of assessment of structural damage in ankylosing spondylitis: Implications for treatment outcomes

(2008) Joachim Sieper et al.   ARTHRITIS AND RHEUMATISM

An overview of IL-17 function and signaling

(2008) Sarah L. Gaffen   CYTOKINE

Structure–function relationships in the IL-17 receptor: Implications for signal transduction and therapy

(2008) Fang Shen et al.   CYTOKINE

IL-17 produced by Paneth cells drives TNF-induced shock

(2008) Nozomi Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

(2008) Michelle A. Lowes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Are spondyloarthropathies as common as rheumatoid arthritis worldwide? A review

(2008) Nurullah Akkoc   Current Rheumatology Reports