Tamoxifen attenuates reactive astrocyte-induced brain metastasis and drug resistance through the IL-6/STAT3 signaling pathway

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

(2018) Neibla Priego et al.   NATURE MEDICINE

Brain Metastases in Newly Diagnosed Breast Cancer

(2017) Allison M. Martin et al.   JAMA Oncology

Tamoxifen Administration Immediately or 24 Hours after Spinal Cord Injury Improves Locomotor Recovery and Reduces Secondary Damage in Female Rats

(2016) Jennifer M. Colón et al.   JOURNAL OF NEUROTRAUMA

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery

(2016) JorgeD Miranda et al.   Neural Regeneration Research

Loss of the Polarity Protein PAR3 Activates STAT3 Signaling via an Atypical Protein Kinase C (aPKC)/NF-κB/Interleukin-6 (IL-6) Axis in Mouse Mammary Cells

(2015) Richard A. Guyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CEREBEL (EGF111438): A Phase III, Randomized, Open-Label Study of Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer

(2015) Xavier Pivot et al.   JOURNAL OF CLINICAL ONCOLOGY

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Estrogen promotes the brain metastatic colonization of triple negative breast cancer cells via an astrocyte-mediated paracrine mechanism

(2015) C A Sartorius et al.   ONCOGENE

Astrocytes Upregulate Survival Genes in Tumor Cells and Induce Protection from Chemotherapy

(2015) Sun-Jin Kim et al.   NEOPLASIA

Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: a retrospective, exploratory analysis in EMILIA

(2014) I. E. Krop et al.   ANNALS OF ONCOLOGY

Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: Their antioxidant effect and role of estrogen receptor alpha

(2014) Laurivette Mosquera et al.   BRAIN RESEARCH

Treatment outcomes and prognostic factors for patients with brain metastases from breast cancer of each subtype: a multicenter retrospective analysis

(2014) Naoki Niikura et al.   BREAST CANCER RESEARCH AND TREATMENT

Role of the Neural Niche in Brain Metastatic Cancer

(2014) J. Termini et al.   CANCER RESEARCH

Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study

(2014) Aki Morikawa et al.   NEURO-ONCOLOGY

Tamoxifen reduces infiltration of inflammatory cells, apoptosis and inhibits IKK/NF-kB pathway after spinal cord injury in rats

(2014) Hong-yu Wei et al.   NEUROLOGICAL SCIENCES

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

(2014) J. Neman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amplification of Distant Estrogen Response Elements Deregulates Target Genes Associated with Tamoxifen Resistance in Breast Cancer

(2013) Pei-Yin Hsu et al.   CANCER CELL

Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain

(2013) Fei Xing et al.   EMBO Molecular Medicine

Carcinoma cells misuse the host tissue damage response to invade the brain

(2013) Han-Ning Chuang et al.   GLIA

Breast cancer brain metastases responding to primary systemic therapy with T-DM1

(2013) Rupert Bartsch et al.   JOURNAL OF NEURO-ONCOLOGY

The Cancer Drug Tamoxifen: A Potential Therapeutic Treatment for Spinal Cord Injury

(2013) Jutatip Guptarak et al.   JOURNAL OF NEUROTRAUMA

Clinicopathologic features, patterns of recurrence, and survival among women with triple-negative breast cancer in the National Comprehensive Cancer Network

(2012) Nancy U. Lin et al.   CANCER

Stromal Estrogen Receptor-  Promotes Tumor Growth by Normalizing an Increased Angiogenesis

(2012) C. Pequeux et al.   CANCER RESEARCH

Estrogen Promotes ER-Negative Tumor Growth and Angiogenesis through Mobilization of Bone Marrow-Derived Monocytes

(2012) V. Iyer et al.   CANCER RESEARCH

Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study

(2012) Thomas Bachelot et al.   LANCET ONCOLOGY

Neuroprotection mediated through estrogen receptor-  in astrocytes

(2011) R. D. Spence et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis

(2010) Toshihiro Seike et al.   CLINICAL & EXPERIMENTAL METASTASIS

Role of astroglia in the neuroplastic and neuroprotective actions of estradiol

(2010) Iñigo Azcoitia et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Role of GFAP in morphological retention and distribution of reactive astrocytes induced by scrapie encephalopathy in mice

(2009) Hiroshi Gomi et al.   BRAIN RESEARCH

Transforming Growth Factor- 2 Is a Molecular Determinant for Site-Specific Melanoma Metastasis in the Brain

(2009) C. Zhang et al.   CANCER RESEARCH

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization

(2008) Daniel P. Fitzgerald et al.   CLINICAL & EXPERIMENTAL METASTASIS

Interleukin-1β-dependent Signaling between Astrocytes and Neurons Depends Critically on Astrocytic Calcineurin/NFAT Activity

(2008) Michelle A. Sama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain

(2007) M. Morissette et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY