Isotyping and Semi-Quantitation of Monkey Anti-Drug Antibodies by Immunocapture Liquid Chromatography-Mass Spectrometry

A method combining blue native polyacrylamide gel electrophoresis with liquid chromatography tandem-mass spectrometry to detect circulating immune complexes between therapeutic monoclonal antibodies and anti-drug antibodies in animals

(2020) Kazuhiro Kobayashi et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses

(2019) William David Tolbert et al.   mAbs

Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry

(2019) Xiaobin Xu et al.   PLoS One

Comparison of different immunoassay methods to detect human anti-drug antibody using the WHO erythropoietin antibody reference panel for analytes

(2018) Hiroko Shibata et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Bridging immunogenicity assays for IgG4 therapeutics: mitigating interference from Fc–Fc interactions

(2017) Michael A Partridge et al.   Bioanalysis

Anti-Hinge Antibodies Recognize IgG Subclass– and Protease-Restricted Neoepitopes

(2016) Willem J. J. Falkenburg et al.   JOURNAL OF IMMUNOLOGY

Immunogenicity of Biotherapeutics: Causes and Association with Posttranslational Modifications

(2016) Anshu Kuriakose et al.   Journal of Immunology Research

Development of Immunocapture-LC/MS Assay for Simultaneous ADA Isotyping and Semiquantitation

(2016) Lin-Zhi Chen et al.   Journal of Immunology Research

Immunogenicity to Biotherapeutics – The Role of Anti-drug Immune Complexes

(2016) Murli Krishna et al.   Frontiers in Immunology

Evaluating and Reporting the Immunogenicity Impacts for Biological Products—a Clinical Pharmacology Perspective

(2015) Yow-Ming C. Wang et al.   AAPS Journal

Immunogenicity assessment of biotherapeutic products: An overview of assays and their utility

(2015) Meenu Wadhwa et al.   BIOLOGICALS

Matrix interference from Fc–Fc interactions in immunoassays for detecting human IgG4 therapeutics

(2015) Michael A Partridge et al.   Bioanalysis

IgG Subclass Specificity Discriminates Restricted IgM Rheumatoid Factor Responses From More Mature Anti-Citrullinated Protein Antibody-Associated or Isotype-Switched IgA Responses

(2015) Willem J. J. Falkenburg et al.   Arthritis & Rheumatology

Innovative Use of LC-MS/MS for Simultaneous Quantitation of Neutralizing Antibody, Residual Drug, and Human Immunoglobulin G in Immunogenicity Assay Development

(2014) Hao Jiang et al.   ANALYTICAL CHEMISTRY

Cynomolgus and pigtail macaque IgG subclasses: characterization of IGHG genes and computational analysis of IgG/Fc receptor binding affinity

(2014) Doan C. Nguyen et al.   IMMUNOGENETICS

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

Immunogenicity assessment in non-clinical studies

(2012) Steven J Swanson et al.   CURRENT OPINION IN MICROBIOLOGY

Molecular and Functional Characterization of Cynomolgus Monkey IgG Subclasses

(2010) F. W. Jacobsen et al.   JOURNAL OF IMMUNOLOGY

Impact of Product-Related Factors on Immunogenicity of Biotherapeutics

(2010) Satish Kumar Singh   JOURNAL OF PHARMACEUTICAL SCIENCES

Immunoglobulin G4: an odd antibody

(2009) R. C. Aalberse et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Assessing Immunogenicity in the Presence of Excess Protein Therapeutic Using Immunoprecipitation and Quantitative Mass Spectrometry

(2008) Hendrik Neubert et al.   ANALYTICAL CHEMISTRY

Selected reaction monitoring for quantitative proteomics: a tutorial

(2008) Vinzenz Lange et al.   Molecular Systems Biology