Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation

PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network

(2020) Kurt M. Reichermeier et al.   MOLECULAR CELL

An allosteric network in spastin couples multiple activities required for microtubule severing

(2019) Colby R. Sandate et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIPK2 Phosphorylates the Microtubule-Severing Enzyme Spastin at S268 for Abscission

(2019) Pisciottani et al.   Cells

Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation

(2019) Han Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Missense mutation of SPAST protein (I344K) results in loss of ATPase activity and prolonged the half-life, implicated in autosomal dominant hereditary spastic paraplegia

(2018) Jung Hwa Lim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression

(2018) Xing Liu et al.   MOLECULAR CELL

Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation

(2018) Annapurna Vemu et al.   SCIENCE

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease

(2017) Natalia Rodriguez-Muela et al.   Cell Reports

Heat shock modulates the subcellular localization, stability, and activity of HIPK2

(2016) Mamta Upadhyay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIPK family kinases bind and regulate the function of the CCR4-NOT complex

(2016) Alfonso Rodriguez-Gil et al.   MOLECULAR BIOLOGY OF THE CELL

Hereditary spastic paraplegia SPG4: what is known and not known about the disease

(2015) Joanna M. Solowska et al.   BRAIN

Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs)

(2015) Han Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia

(2015) Hans Zempel et al.   Molecular Neurodegeneration

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Integration of stress signals by homeodomain interacting protein kinases

(2014) Michael Lienhard Schmitz et al.   BIOLOGICAL CHEMISTRY

Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons

(2014) S. Havlicek et al.   HUMAN MOLECULAR GENETICS

Pathogenic Mutation of Spastin Has Gain-of-Function Effects on Microtubule Dynamics

(2014) J. M. Solowska et al.   JOURNAL OF NEUROSCIENCE

Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia

(2014) Y. Fan et al.   Biology Open

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

(2013) Hans Zempel et al.   EMBO JOURNAL

An ESCRT–spastin interaction promotes fission of recycling tubules from the endosome

(2013) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

Loss of Spastin Function Results in Disease-Specific Axonal Defects in Human Pluripotent Stem Cell-Based Models of Hereditary Spastic Paraplegia

(2013) Kyle R. Denton et al.   STEM CELLS

Cellular Pathways of Hereditary Spastic Paraplegia

(2012) Craig Blackstone   Annual Review of Neuroscience

Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice

(2012) C. Fassier et al.   Disease Models & Mechanisms

Microtubule-severing enzymes at the cutting edge

(2012) D. J. Sharp et al.   JOURNAL OF CELL SCIENCE

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer

(2012) Gabriella D’Orazi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

N-Terminal Phosphorylation of p60 Katanin Directly Regulates Microtubule Severing

(2012) Evan Whitehead et al.   JOURNAL OF MOLECULAR BIOLOGY

Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues

(2012) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

HIPK2 Controls Cytokinesis and Prevents Tetraploidization by Phosphorylating Histone H2B at the Midbody

(2012) Cinzia Rinaldo et al.   MOLECULAR CELL

Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration

(2012) Michelle C. Stone et al.   Cell Reports

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation

(2011) Eduarda Dráberová et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia

(2010) J. M. Solowska et al.   HUMAN MOLECULAR GENETICS

Pleiotropic effects of spastin on neurite growth depending on expression levels

(2009) Elena Riano et al.   JOURNAL OF NEUROCHEMISTRY

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

(2009) Paul R. Kasher et al.   JOURNAL OF NEUROCHEMISTRY

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

A cryptic promoter in the first exon of the SPG4 gene directs the synthesis of the 60-kDa spastin isoform

(2008) Giuseppe Mancuso et al.   BMC BIOLOGY

Expansion of mutation spectrum, determination of mutation cluster regions and predictive structural classification of SPAST mutations in hereditary spastic paraplegia

(2008) Moneef Shoukier et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

(2008) Antonina Roll-Mecak et al.   NATURE

Spastin Couples Microtubule Severing to Membrane Traffic in Completion of Cytokinesis and Secretion

(2008) James W. Connell et al.   TRAFFIC