HIPK2 Phosphorylates the Microtubule-Severing Enzyme Spastin at S268 for Abscission

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis

(2018) Laura Monteonofrio et al.   ONCOGENE

ESCRT-dependent control of membrane remodelling during cell division

(2018) Caroline Louise Stoten et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM

(2018) Inna Goliand et al.   Cell Reports

CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope

(2018) Leandro N. Ventimiglia et al.   DEVELOPMENTAL CELL

Microtubule-severing enzymes: From cellular functions to molecular mechanism

(2018) Francis J. McNally et al.   JOURNAL OF CELL BIOLOGY

Playing polo during mitosis: PLK1 takes the lead

(2017) G Combes et al.   ONCOGENE

Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain

(2017) Antonella Scaglione et al.   PROTEIN SCIENCE

The Abscission Checkpoint: Making It to the Final Cut

(2017) Viola Nähse et al.   TRENDS IN CELL BIOLOGY

Late mitotic functions of Aurora kinases

(2016) Olga Afonso et al.   CHROMOSOMA

Regulation of midbody formation and function by mitotic kinases

(2016) Pier Paolo D’Avino et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cytokinesis in Metazoa and Fungi

(2016) Michael Glotzer   Cold Spring Harbor Perspectives in Biology

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity

(2015) Davide Valente et al.   Oncotarget

Spastin Binds to Lipid Droplets and Affects Lipid Metabolism

(2015) Chrisovalantis Papadopoulos et al.   PLoS Genetics

Cytokinetic Abscission: Molecular Mechanisms and Temporal Control

(2014) Beata Mierzwa et al.   DEVELOPMENTAL CELL

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation

(2013) Francesca Siepi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An ESCRT–spastin interaction promotes fission of recycling tubules from the endosome

(2013) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer

(2012) Gabriella D’Orazi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

N-Terminal Phosphorylation of p60 Katanin Directly Regulates Microtubule Severing

(2012) Evan Whitehead et al.   JOURNAL OF MOLECULAR BIOLOGY

Midbody assembly and its regulation during cytokinesis

(2012) Chi-Kuo Hu et al.   MOLECULAR BIOLOGY OF THE CELL

HIPK2 Controls Cytokinesis and Prevents Tetraploidization by Phosphorylating Histone H2B at the Midbody

(2012) Cinzia Rinaldo et al.   MOLECULAR CELL

Transcriptional and Post-Transcriptional Regulation of SPAST, the Gene Most Frequently Mutated in Hereditary Spastic Paraplegia

(2012) Brian J. Henson et al.   PLoS One

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

(2012) Vera V. Saul et al.   Journal of Molecular Cell Biology

SPG4 gene promoter regulation via Elk1 transcription factor

(2011) Derya Canbaz et al.   JOURNAL OF NEUROCHEMISTRY

Cortical Constriction During Abscission Involves Helices of ESCRT-III-Dependent Filaments

(2011) J. Guizetti et al.   SCIENCE

Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia

(2010) J. M. Solowska et al.   HUMAN MOLECULAR GENETICS

Pleiotropic effects of spastin on neurite growth depending on expression levels

(2009) Elena Riano et al.   JOURNAL OF NEUROCHEMISTRY

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase

(2009) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

A cryptic promoter in the first exon of the SPG4 gene directs the synthesis of the 60-kDa spastin isoform

(2008) Giuseppe Mancuso et al.   BMC BIOLOGY

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B

(2008) Dong Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spastin Couples Microtubule Severing to Membrane Traffic in Completion of Cytokinesis and Secretion

(2008) James W. Connell et al.   TRAFFIC