Article
Fisheries
Zohre Khorshidi, Hamed Paknejad, Mohammad Sodagar, Abdolmajid Hajimoradloo, Seyed Pezhman Hosseini Shekarabi
Summary: This study investigated the effects of dietary addition of BT on growth performance, digestive enzymes activity, intestine pH, and gene expression in common carp fingerlings. The results showed that the addition of BT at 2 g/kg improved growth performance and digestive enzyme activity. It also led to a decrease in feed conversion ratio and a decrease in intestine pH. Additionally, BT up-regulated the expression of growth-related and intestinal tight junction protein genes.
Article
Biotechnology & Applied Microbiology
M. Pena-Rodriguez, N. Vega-Magana, Leonel Garcia-Benavides, J. S. Zepeda-Nuno, G. Y. Gutierrez-Silerio, L. A. Gonzalez-Hernandez, J. F. Andrade-Villanueva, S. Del Toro-Arreola, A. L. Pereira-Suarez, M. R. Bueno-Topete
Summary: The study showed that butyrate effectively regulates inflammatory response, tight junction protein expression, and limits bacterial diversity loss in cirrhosis patients. This research suggests that butyrate could be an interesting postbiotic metabolomic intervention for intestinal epithelium dysfunction in liver disease.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zahra Sobhani, Cheng Fang, Ravi Naidu, Mallavarapu Megharaj
Summary: The accumulation of microplastics in soil has become a serious global issue, impacting living organisms and the environment. Research shows that the presence of microplastics in soil significantly increases the bioaccumulation risk of perfluorooctane sulfonate and perfluorooctanoic acid in earthworms, affecting their reproduction negatively.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Environmental Sciences
Karen K. Chiu, Shah Tauseef Bashir, Ahmed M. Abdel-Hamid, Lindsay V. Clark, Mary J. Laws, Isaac Cann, Romana A. Nowak, Jodi A. Flaws
Summary: This study examines the impact of DiNP exposure on the gut microbiota and immune-related factors, revealing that DiNP exposure can alter the composition of the gut microbiota and that the gut contains microbes capable of degrading DiNP.
Article
Multidisciplinary Sciences
Jiexi Li, Zhengdao Lan, Wenting Liao, James W. W. Horner, Xueping Xu, Jielin Liu, Yohei Yoshihama, Shan Jiang, Hong Seok Shim, Max Slotnik, Kyle A. A. LaBella, Chang-Jiun Wu, Kenneth Dunner Jr, Wen-Hao Hsu, Rumi Lee, Isha Khanduri, Christopher Terranova, Kadir Akdemir, Deepavali Chakravarti, Xiaoying Shang, Denise J. J. Spring, Y. Alan Wang, Ronald A. A. DePinho
Summary: Sex plays an important role in cancer incidence, spectrum, and outcomes, particularly in colorectal cancer (CRC) where men have higher metastases and mortality rates. A study using a murine CRC model revealed that oncogenic mutant KRAS (KRAS*) CRC in males showed higher metastases and worse outcomes. Further analysis found that the Y-chromosome gene histone demethylase KDM5D, driven by KRAS*-mediated activation of the STAT4 transcription factor, contributed to the sex differences in KRAS* CRC. Deletion of Kdm5d in cancer cells improved tight junction integrity, reduced invasiveness, and enhanced cancer cell killing by CD8(+) T cells. On the contrary, mice with a Kdm5d transgene had a higher propensity for invasive tumors. Therefore, the upregulation of Y chromosome KDM5D via KRAS*-STAT4 pathway disrupts cancer cell adhesion properties and tumor immunity, providing a potential therapeutic strategy for reducing metastasis risk in men with KRAS* CRC.
Review
Environmental Sciences
Yulong Li, Liuyang He, Lixin Lv, Jianming Xue, Li Wu, Zulin Zhang, Lie Yang
Summary: Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) have raised concerns due to their persistence, wide distribution, biotoxicity, and bioaccumulative properties. Phytoremediation offers a promising alternative to traditional cleanup methods for PFOA and PFOS. This review discusses the uptake, translocation, and toxic effects of PFOS and PFOA, as well as potential hyperaccumulators and indicators of biotoxicity for these chemicals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Veterinary Sciences
Gerardo A. Abascal-Ponciano, Samuel F. Leiva, Joshua J. Flees, Luis P. Avila, Jessica D. Starkey, Charles W. Starkey
Summary: Vitamin D signaling plays an important role in maintaining intestinal homeostasis by regulating cell phenotype and cytokine secretion. Inflammation in intestinal tissues can disrupt the cell structure and compromise the protective barrier. This study found that dietary supplementation with 25OHD3 can decrease the abundance of inflammatory cytokines in the ileum of broiler chickens.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Nutrition & Dietetics
Hisanori Muto, Takashi Honda, Taku Tanaka, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Norihiro Imai, Yoji Ishizu, Keiko Maeda, Tetsuya Ishikawa, Shungo Adachi, Chikara Sato, Noriko M. Tsuji, Masatoshi Ishigami, Mitsuhiro Fujishiro, Hiroki Kawashima
Summary: The impact of a high-fat diet on intestinal permeability is well documented, but the exact mechanism behind leaky gut caused by an HFD is unclear. In this study, researchers investigated the mechanism underlying HFD-induced leaky gut and found an increase in fat accumulation in the liver and a trend towards increased intestinal permeability in mice fed an HFD. Proteomics analysis revealed differentially expressed proteins related to endocytosis, protein transport, and tight junctions in the small intestine epithelial cells. The study also identified a correlation between the expression of Cldn7 and intestinal barrier function, as well as its strong correlation with Epcam.
Article
Biochemistry & Molecular Biology
Dario E. Iglesias, Eleonora Cremonini, Shelly N. Hester, Steven M. Wood, Mark Bartlett, Cesar G. Fraga, Patricia I. Oteiza
Summary: This study found that supplementation with an anthocyanin-rich extract can prevent or reverse the damage to colonic physiology caused by a high-fat diet, possibly through the regulation of TLR-4 and redox-regulated signaling.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Hsin-I. Huang, Mark L. Jewell, Nourhan Youssef, Min-Nung Huang, Elizabeth R. Hauser, Brian E. Fee, Nathan P. Rudemiller, Jamie R. Privratsky, Junyi J. Zhang, Estefany Y. Reyes, Donghai Wang, Gregory A. Taylor, Michael D. Gunn, Dennis C. Ko, Donald N. Cook, Vidyalakshmi Chandramohan, Steven D. Crowley, Gianna Elena Hammer
Summary: Intestinal immunity is regulated by distinct mononuclear phagocyte populations, with colon-specific subsets of macrophages and Th17-inducing dendritic cells identified. These colon-specific cells express CD24 and CD14, and are dependent on the transcription factor IRF4. They play essential roles in Th17 immunity in the colon, demonstrating organ-specific requirements for antigen presenting cells in Th17 immunity in the colon and small intestine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Polymer Science
Cong-Yu Wang, Min Sun, Zhen Fan, Jian-Zhong Du
Summary: An intestine enzyme-responsive hydrogel was developed to encapsulate hydrophobic imatinib with long-term controlled release and enhanced intestinal permeability. The hydrogel showed improved therapeutic efficiency compared to imatinib mesylate, providing an effective approach to improve the bioavailability of hydrophobic anticancer drugs with oral administration.
CHINESE JOURNAL OF POLYMER SCIENCE
(2022)
Article
Multidisciplinary Sciences
Atul K. Srivastava, Bharat Somireddy Venkata, Yan Y. Sweat, Heather R. Rizzo, Lea Jean-Francois, Li Zuo, Kathleen W. Kurgan, Patrick Moore, Nitesh Shashikanth, Izabela Smok, Joseph R. Sachleben, Jerrold R. Turner, Stephen C. Meredith
Summary: This study investigates the effects of S408 phosphorylation on occludin protein structure and demonstrates its role in regulating intercellular junction function through interactions with other components.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Amin Mojiri, Mansoureh Nazari Vishkaei, Hanieh Khoshnevis Ansari, Mohammadtaghi Vakili, Hossein Farraji, Norhafezah Kasmuri
Summary: In this study, the toxicity effects of PFOS and PFOA mixture on two microalgae species were investigated. The results showed that the cell viability, chlorophyll content, and protein content decreased with increased contact time and PFAS concentration, with a greater decrease observed in Scenedesmus obliquus. The toxicity effects were further optimized using response surface methodology and studied through molecular docking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
A. C. E. Pupim, C. R. Basso, C. C. A. Machado, P. S. Watanabe, G. S. A. Fernandes, R. P. ErthalL, G. B. C. Sodre, F. A. Guarnier, A. N. C. Simao, E. J. A. Araujo
Summary: This study aims to evaluate the effects of prolonged oral exposure to low levels of Malathion on the structure and motility of the colon in young rats. The results showed that long-term exposure to Malathion caused changes in colonic morphophysiology, highlighting the need for better control and care in the use of this pesticide.
Review
Clinical Neurology
Riccardo Serra, J. Marc Simard
Summary: This article reviews 45 research articles on intercellular junctions in the ependyma, indicating the important role of ependymal lining ultrastructure in fluid flow interactions in the brain. These findings have implications for understanding and treating CSF-related disorders.
FRONTIERS IN NEUROLOGY
(2023)
Article
Environmental Sciences
Faizan Rashid, Veronika Dubinkina, Saeed Ahmad, Sergei Maslov, Joseph Maria Kumar Irudayaraj
Summary: Exposure to PFOS and GenX has different effects on the microbiome of the small intestine and colon, as well as on liver metabolism. High doses of GenX increase the abundance of certain bacteria, while PFOS generally alters the abundance of other bacteria. These treatments are associated with alterations in important microbial metabolic pathways. Additionally, PFOS and GenX exposure can cause metabolic disorders in the liver.
Article
Genetics & Heredity
Yi Wen, Faizan Rashid, Zeeshan Fazal, Ratnakar Singh, Michael J. Spinella, Joseph Irudayaraj
Summary: The study showed that PFOS accumulated in mouse kidneys in a dose-dependent manner, leading to significant increase in kidney injury markers, affecting transcription factors and epigenetic mechanisms. The decrease in global DNA methylation levels suggests potential implications of PFOS on kidney fibrosis and carcinogenesis.
ENVIRONMENTAL EPIGENETICS
(2022)
Article
Pharmacology & Pharmacy
Rabia Zahid, Hafiz Muhammad Asif, Faisal Rasheed, Faizan Rashid, Rubina Kamran, Kanwal Ahmed, Sheikh Abdul Saeed, Jibran Sualeh Muhammad, Muhammad Akram, Syed Faisal Zaidi
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Public, Environmental & Occupational Health
Samreen Sarwar, Sadaf Ilyas, Bilal Ahmed Khan, Danielle C. Lohman, Saleha Haffez, Madiha Rafique, Faizan Rashid, Junaid Akhtar, Saeed Khan, Aurora O. Amoah
Article
Toxicology
Faizan Rashid, Anujaianthi Ramakrishnan, Christopher Fields, Joseph Irudayaraj
TOXICOLOGY REPORTS
(2020)