Emerging medical therapies for severe alcoholic hepatitis

Efficacy of g-csf in the management of steroid-nonresponsive severe alcoholic hepatitis: a double-blind randomized controlled trial

(2019) Shasthry Saggere Muralikrishna et al.   HEPATOLOGY

Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study

(2019) Gyongyi Szabo et al.   HEPATOLOGY

Contribution of Zinc and Zinc Transporters in the Pathogenesis of Inflammatory Bowel Diseases

(2019) Wakana Ohashi et al.   Journal of Immunology Research

Biomarkers of macrophage activation and immune danger signals predict clinical outcomes in alcoholic hepatitis

(2019) Banishree Saha et al.   HEPATOLOGY

Dysregulated autophagy and lysosome function are linked to exosome production via miR‐155 in alcoholic liver disease

(2019) Mrigya Babuta et al.   HEPATOLOGY

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

(2019) Yi Duan et al.   NATURE

A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis

(2019) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-stage Liver Disease Scores Compared With Placebo

(2018) Catherine T. Frenette et al.   Clinical Gastroenterology and Hepatology

Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis

(2018) Thoetchai (Bee) Peeraphatdit et al.   JOURNAL OF HEPATOLOGY

Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial

(2018) Julie Thompson et al.   LIVER TRANSPLANTATION

Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury

(2018) Shengda Lin et al.   NATURE

Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis and inflammation in mice

(2018) Aditya Ambade et al.   HEPATOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

(2016) Vikas K. Verma et al.   JOURNAL OF HEPATOLOGY

How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?

(2016) Muhammad Babar Khawar et al.   Journal of Immunology Research

Effects of probiotics (cultured Lactobacillus subtilis/Streptococcus faecium) in the treatment of alcoholic hepatitis

(2015) Sang Hak Han et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients With Acute Alcoholic Hepatitis

(2015) Lee J.L. Markwick et al.   GASTROENTEROLOGY

Combination of Granulocyte Colony-Stimulating Factor and Erythropoietin Improves Outcomes of Patients With Decompensated Cirrhosis

(2015) Chandan Kumar Kedarisetty et al.   GASTROENTEROLOGY

Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease

(2015) M Llopis et al.   GUT

Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice

(2015) Arvin Iracheta-Vellve et al.   JOURNAL OF HEPATOLOGY

Prednisolone or Pentoxifylline for Alcoholic Hepatitis

(2015) Mark R. Thursz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis

(2015) Fátima Higuera-de la Tijera   WORLD JOURNAL OF GASTROENTEROLOGY

Micro-RNA-155 Deficiency Prevents Alcohol-Induced Serum Endotoxin Increase and Small Bowel Inflammation in Mice

(2014) Dora Lippai et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Granulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis: A Randomized Pilot Study

(2014) Virendra Singh et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease

(2014) Jiao-Ya Xu   WORLD JOURNAL OF GASTROENTEROLOGY

Immune dysfunction in cirrhosis

(2014) Nora Sipeki   WORLD JOURNAL OF GASTROENTEROLOGY

Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease

(2013) Weibin Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

(2013) Len Verbeke et al.   HEPATOLOGY

Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury

(2013) Yuhua Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

(2012) Shashi Bala et al.   HEPATOLOGY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Management of alcoholic hepatitis

(2012) Philippe Mathurin et al.   JOURNAL OF HEPATOLOGY

S-adenosylmethionine (SAMe) therapy in liver disease: A review of current evidence and clinical utility

(2012) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Granulocyte Colony–Stimulating Factor Mobilizes CD34+ Cells and Improves Survival of Patients With Acute-on-Chronic Liver Failure

(2011) Vishal Garg et al.   GASTROENTEROLOGY

Glucocorticoids plusN-Acetylcysteine in Severe Alcoholic Hepatitis

(2011) Eric Nguyen-Khac et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rifaximin treatment for reduction of risk of overt hepatic encephalopathy recurrence

(2011) Steven L. Flamm   Therapeutic Advances in Gastroenterology

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Enteric dysbiosis associated with a mouse model of alcoholic liver disease

(2010) Arthur W. Yan et al.   HEPATOLOGY

Enteral nutrition with or without N-acetylcysteine in the treatment of severe acute alcoholic hepatitis: A randomized multicenter controlled trial

(2010) Christophe Moreno et al.   JOURNAL OF HEPATOLOGY

Infection in Patients With Severe Alcoholic Hepatitis Treated With Steroids: Early Response to Therapy Is the Key Factor

(2009) Alexandre Louvet et al.   GASTROENTEROLOGY

Bovine Colostrum Prevents Bacterial Translocation in an Intestinal Ischemia/Reperfusion-Injured Rat Model

(2009) Han Sung Choi et al.   JOURNAL OF MEDICINAL FOOD

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

(2009) Helen J. Lachmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alcoholic Hepatitis

(2009) Michael R. Lucey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study

(2008) Irina A. Kirpich et al.   ALCOHOL

A Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial of Etanercept in the Treatment of Alcoholic Hepatitis

(2008) Nicholas C. Boetticher et al.   GASTROENTEROLOGY

Terlipressin and Albumin vs Albumin in Patients With Cirrhosis and Hepatorenal Syndrome: A Randomized Study

(2008) Marta Martín–Llahí et al.   GASTROENTEROLOGY

A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome

(2008) Arun J. Sanyal et al.   GASTROENTEROLOGY

Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: A randomized trial

(2008) Laurent Spahr et al.   HEPATOLOGY

Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis

(2008) Vanessa Stadlbauer et al.   JOURNAL OF HEPATOLOGY

The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis

(2008) Rieke Alten et al.   ARTHRITIS RESEARCH & THERAPY