Precision medicine in nonalcoholic fatty liver disease: New therapeutic insights from genetics and systems biology

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

(2020) Silvia Sookoian et al.   GUT

Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials

(2020) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Why do so many NASH trials fail?

(2020) Vlad Ratziu et al.   GASTROENTEROLOGY

Genetic pathways in nonalcoholic fatty liver disease: Insights from systems biology

(2020) Silvia Sookoian et al.   HEPATOLOGY

Hepatic molecular signatures highlight the sexual dimorphism of Non‐Alcoholic SteatoHepatitis (NASH)

(2020) Jimmy Vandel et al.   HEPATOLOGY

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort

(2020) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Epigenetics factors in nonalcoholic fatty liver disease

(2020) Carlos Jose Pirola et al.   Expert Review of Gastroenterology & Hepatology

Sexual Dimorphism of NAFLD in Adults. Focus on Clinical Aspects and Implications for Practice and Translational Research

(2020) Amedeo Lonardo et al.   Journal of Clinical Medicine

Liver mitochondrial DNA damage and genetic variability of Cytochrome b – a key component of the respirasome – drive the severity of fatty liver disease

(2020) C. J. Pirola et al.   JOURNAL OF INTERNAL MEDICINE

Genetics of Nonalcoholic Fatty Liver Disease: From Pathogenesis to Therapeutics

(2019) Silvia Sookoian et al.   SEMINARS IN LIVER DISEASE

Sex Differences in NAFLD : State of the Art and Identification of Research Gaps

(2019) Amedeo Lonardo et al.   HEPATOLOGY

Repurposing drugs to target nonalcoholic steatohepatitis

(2019) Silvia Sookoian et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension

(2019) Naga Chalasani et al.   GASTROENTEROLOGY

Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension

(2019) Guadalupe Garcia-Tsao et al.   JOURNAL OF HEPATOLOGY

A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis

(2019) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Simtuzumab Is Ineffective for Patients with Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis

(2018) Stephen A. Harrison et al.   GASTROENTEROLOGY

Genetic Polymorphisms of PNPLA3 and SAMM50 Are Associated with Nonalcoholic Fatty Liver Disease in a Korean Population

(2018) Goh Eun Chung et al.   Gut and Liver

Additive effects of PNPLA3 and TM6SF2 on the histological severity of non-alcoholic fatty liver disease

(2018) Bo Kyung Koo et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Genetic determinants of hepatic steatosis and serum cytokeratin-18 fragment levels in Taiwanese children

(2018) Yu-Cheng Lin et al.   LIVER INTERNATIONAL

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

(2018) Noura S. Abul-Husn et al.   NEW ENGLAND JOURNAL OF MEDICINE

GlobAl Distribution of GEnetic Traits (GADGET) web server: polygenic trait scores worldwide

(2018) Aroon T Chande et al.   NUCLEIC ACIDS RESEARCH

Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers

(2018) Takahisa Kawaguchi et al.   PLoS One

Multiomics biomarkers for the prediction of nonalcoholic fatty liver disease severity

(2018) Carlos J Pirola et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Massive mining of publicly available RNA-seq data from human and mouse

(2018) Alexander Lachmann et al.   Nature Communications

Lack of evidence supporting a role of TMC4-rs641738 missense variant—MBOAT7- intergenic downstream variant—in the Susceptibility to Nonalcoholic Fatty Liver Disease

(2018) Silvia Sookoian et al.   Scientific Reports

Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity

(2018) Silvia Sookoian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genetics meets Therapy? Exome-wide association study reveals a loss-of-function variant in HSD17B13 (17-beta-hydroxysteroid dehydrogenase 13) that protects patients from liver damage and NAFLD-progression

(2018) Silvia Sookoian et al.   HEPATOLOGY

Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease

(2018) Carlos J. Pirola et al.   JOURNAL OF LIPID RESEARCH

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

(2017) Rohit Loomba et al.   HEPATOLOGY

Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level1,2

(2016) Silvia Sookoian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

Nonalcoholic fatty liver disease and metabolic syndrome: Shared genetic basis of pathogenesis

(2016) Silvia Sookoian et al.   HEPATOLOGY

Mitochondrial genome architecture in non-alcoholic fatty liver disease

(2016) Silvia Sookoian et al.   JOURNAL OF PATHOLOGY

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

Meta-analysis of the influence of TM6SF2 E167K variant on Plasma Concentration of Aminotransferases across different Populations and Diverse Liver Phenotypes

(2016) Silvia Sookoian et al.   Scientific Reports

The dual and opposite role of theTM6SF2-rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta-analysis

(2015) Carlos J. Pirola et al.   HEPATOLOGY

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity

(2015) Silvia Sookoian et al.   HEPATOLOGY

Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease

(2015) Carlos J. Pirola et al.   MEDICINE

Nonalcoholic fatty liver disease

(2015) Elizabeth M. Brunt et al.   Nature Reviews Disease Primers

A common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: A meta-analysis

(2014) Shamsul Mohd Zain et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

(2014) H. Mahdessian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   HEPATOLOGY

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

(2010) Alexander Lachmann et al.   BIOINFORMATICS

Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter

(2010) Silvia Sookoian et al.   HEPATOLOGY

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS