Bedaquiline inhibits the yeast and human mitochondrial ATP synthases

Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1

(2019) Jinke Gu et al.   SCIENCE

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

(2018) Hamish S. Sutherland et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ionophoric effects of the antitubercular drug bedaquiline

(2018) Kiel Hards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane

(2018) Anurag P. Srivastava et al.   SCIENCE

Structure, mechanism, and regulation of the chloroplast ATP synthase

(2018) Alexander Hahn et al.   SCIENCE

Easier cure for resistant TB

(2017) Jon Cohen   SCIENCE

Atomic model for the dimeric FOregion of mitochondrial ATP synthase

(2017) Hui Guo et al.   SCIENCE

Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

(2016) Marco Fiorillo et al.   Aging-US

Structure and mechanism of the ATP synthase membrane motor inferred from quantitative integrative modeling

(2016) Vanessa Leone et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mitochondrial function as a therapeutic target in heart failure

(2016) David A. Brown et al.   Nature Reviews Cardiology

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

(2016) Dirk A. Lamprecht et al.   Nature Communications

Asynchronous data acquisition and on-the-fly analysis of dose fractionated cryoEM images by UCSFImage

(2015) Xueming Li et al.   JOURNAL OF STRUCTURAL BIOLOGY

Antiinfectives targeting enzymes and the proton motive force

(2015) Xinxin Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline

(2015) L. Preiss et al.   Science Advances

The depletion of F1 subunit ε in yeast leads to an uncoupled respiratory phenotype that is rescued by mutations in the proton-translocating subunits of F0

(2014) Emmanuel Tetaud et al.   MOLECULAR BIOLOGY OF THE CELL

FDA Approval of Bedaquiline — The Benefit–Risk Balance for Drug-Resistant Tuberculosis

(2014) Edward Cox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bedaquiline: A Novel Antitubercular Agent for the Treatment of Multidrug-Resistant Tuberculosis

(2014) Marylee V. Worley et al.   PHARMACOTHERAPY

The ATP synthase: the understood, the uncertain and the unknown

(2013) John E. Walker   BIOCHEMICAL SOCIETY TRANSACTIONS

Automated Force Field Parameterization for Nonpolarizable and Polarizable Atomic Models Based on Ab Initio Target Data

(2013) Lei Huang et al.   Journal of Chemical Theory and Computation

Novel Antibiotics Targeting Respiratory ATP Synthesis in Gram-Positive Pathogenic Bacteria

(2012) Wendy Balemans et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

Structure of the c10 ring of the yeast mitochondrial ATP synthase in the open conformation

(2012) Jindrich Symersky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oligomycin frames a common drug-binding site in the ATP synthase

(2012) J. Symersky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diagnosis and treatment of mitochondrial myopathies

(2011) Gerald Pfeffer et al.   ANNALS OF MEDICINE

Characterization of the mitochondrial ATP synthase from yeast Saccharomyces cerevisae

(2011) Vijayakanth Pagadala et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

GRIFFIN: A Versatile Methodology for Optimization of Protein−Lipid Interfaces for Membrane Protein Simulations

(2011) René Staritzbichler et al.   Journal of Chemical Theory and Computation

Probing the Interaction of the Diarylquinoline TMC207 with Its Target Mycobacterial ATP Synthase

(2011) Anna C. Haagsma et al.   PLoS One

ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction

(2010) Anna C. Haagsma et al.   FEMS MICROBIOLOGY LETTERS

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Microscopic rotary mechanism of ion translocation in the Fo complex of ATP synthases

(2010) Denys Pogoryelov et al.   Nature Chemical Biology

Mitochondrial DNA mutations and human disease

(2009) Helen A.L. Tuppen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Selectivity of TMC207 towards Mycobacterial ATP Synthase Compared with That towards the Eukaryotic Homologue

(2008) A. C. Haagsma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ATP Synthase and the Actions of Inhibitors Utilized To Study Its Roles in Human Health, Disease, and Other Scientific Areas

(2008) S. Hong et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS