Towards Better Delivery of Cannabidiol (CBD)

Quantification of the content of cannabinol in commercially available e-liquids and studies on their thermal and photo-stability

(2020) Carlo Mazzetti et al.   Scientific Reports

Prolonged oral transmucosal delivery of highly lipophilic drug cannabidiol

(2020) Constantin Itin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials

(2020) Edward Chesney et al.   NEUROPSYCHOPHARMACOLOGY

Cannabidiol efficacy independent of clobazam: Meta‐analysis of four randomized controlled trials

(2020) Orrin Devinsky et al.   ACTA NEUROLOGICA SCANDINAVICA

Pharmacodynamic effects of vaporized and oral cannabidiol (CBD) and vaporized CBD-dominant cannabis in infrequent cannabis users

(2020) Tory R. Spindle et al.   DRUG AND ALCOHOL DEPENDENCE

A perspective on the physicochemical and biopharmaceutic properties of marketed antiseizure drugs—From phenobarbital to cenobamate and beyond

(2020) Reem Odi et al.   EPILEPSIA

A Phase 1, Open‐Label, Parallel‐Group, Single‐Dose Trial of the Pharmacokinetics and Safety of Cannabidiol (CBD) in Subjects With Mild to Severe Hepatic Impairment

(2019) Lesley Taylor et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Parasitic pharmacology: A plausible mechanism of action for cannabidiol

(2019) Geert Jan Groeneveld et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A systematic review of cannabidiol dosing in clinical populations

(2019) S.A. Millar et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy

(2019) Valentina Franco et al.   DRUGS

Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy

(2019) Angela K. Birnbaum et al.   EPILEPSIA

Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use

(2019) Joshua D. Brown et al.   Journal of Clinical Medicine

Examination of a New Delivery Approach for Oral Cannabidiol in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Pharmacokinetics Study

(2019) Alexander Patrician et al.   ADVANCES IN THERAPY

The safety, tolerability, and effectiveness of PTL-101, an oral cannabidiol formulation, in pediatric intractable epilepsy: A phase II, open-label, single-center study

(2019) Alexis Mitelpunkt et al.   EPILEPSY & BEHAVIOR

A meta-opinion: cannabinoids delivered to oral mucosa by a spray for systemic absorption are rather ingested into gastro-intestinal tract: the influences of fed / fasting states

(2019) Constantin Itin et al.   Expert Opinion on Drug Delivery

A phase 1/2, open-label assessment of the safety, tolerability, and efficacy of transdermal cannabidiol (ZYN002) for the treatment of pediatric fragile X syndrome

(2019) Helen Heussler et al.   Journal of Neurodevelopmental Disorders

A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy Subjects

(2019) Katharina Knaub et al.   MOLECULES

Comprehensive quality evaluation of medical Cannabis sativa L. inflorescence and macerated oils based on HS-SPME coupled to GC–MS and LC-HRMS (q-exactive orbitrap®) approach

(2018) Lorenzo Calvi et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

PTL401, a New Formulation Based on Pro-Nano Dispersion Technology, Improves Oral Cannabinoids Bioavailability in Healthy Volunteers

(2018) Jacob Atsmon et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

(2018) Elizabeth A Thiele et al.   LANCET

Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome

(2018) Orrin Devinsky et al.   NEUROLOGY

Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome

(2018) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cannabinoid Delivery Systems for Pain and Inflammation Treatment

(2018) Natascia Bruni et al.   MOLECULES

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects

(2018) Lesley Taylor et al.   CNS DRUGS

A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans

(2018) Sophie A. Millar et al.   Frontiers in Pharmacology

Piperine-pro-nanolipospheres as a novel oral delivery system of cannabinoids: Pharmacokinetic evaluation in healthy volunteers in comparison to buccal spray administration

(2017) Irina Cherniakov et al.   JOURNAL OF CONTROLLED RELEASE

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmaceutical cocrystals: walking the talk

(2016) Geetha Bolla et al.   CHEMICAL COMMUNICATIONS

Pharmaceutical cocrystals: along the path to improved medicines

(2016) Naga K. Duggirala et al.   CHEMICAL COMMUNICATIONS

Cannabinoids and Cytochrome P450 Interactions

(2016) Ondřej Zendulka et al.   CURRENT DRUG METABOLISM

Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex

(2016) Evan J. Hess et al.   EPILEPSIA

Cannabidiol in patients with treatment-resistant epilepsy – Authors' reply

(2016) Orrin Devinsky et al.   LANCET NEUROLOGY

Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial

(2016) Orrin Devinsky et al.   LANCET NEUROLOGY

A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray

(2012) C. G. Stott et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Evaluation of Consistency in Dosing Directions and Measuring Devices for Pediatric Nonprescription Liquid Medications

(2010) H. Shonna Yin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Solid-State Forms of Sodium Valproate, Active Component of the Anticonvulsant Drug Epilim

(2008) Gjorgi Petruševski et al.   ChemMedChem