Pharmaceutical cocrystals: walking the talk

Cocrystals and alloys of nitazoxanide: enhanced pharmacokinetics

(2016) Kuthuru Suresh et al.   CHEMICAL COMMUNICATIONS

Drug–drug co-crystallization presents a new opportunity for the development of stable vitamins

(2016) Jian-Rong Wang et al.   CHEMICAL COMMUNICATIONS

Pharmaceutical cocrystals: along the path to improved medicines

(2016) Naga K. Duggirala et al.   CHEMICAL COMMUNICATIONS

Can we exchange water in a hydrate structure: a case study of etoricoxib

(2016) Sudhir Mittapalli et al.   CRYSTENGCOMM

Crystal engineering and IUCrJ

(2016) Gautam R. Desiraju   IUCrJ

Binary and ternary cocrystals of sulfa drug acetazolamide with pyridine carboxamides and cyclic amides

(2016) Geetha Bolla et al.   IUCrJ

Reinventing Chemistry

(2015) George M. Whitesides   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multicomponent ternary cocrystals of the sulfonamide group with pyridine-amides and lactams

(2015) Geetha Bolla et al.   CHEMICAL COMMUNICATIONS

Hydrogen Bond Synthons in the Interplay of Solubility and Membrane Permeability/Diffusion in Variable Stoichiometry Drug Cocrystals

(2015) Basanta Saikia et al.   CRYSTAL GROWTH & DESIGN

Ionic, Neutral, and Hybrid Acid–Base Crystalline Adducts of Lamotrigine with Improved Pharmaceutical Performance

(2015) Rajesh Thipparaboina et al.   CRYSTAL GROWTH & DESIGN

Direct evidence of polyamorphism in paracetamol

(2015) Yen Nguyen Thi et al.   CRYSTENGCOMM

Tuning Mechanical Properties of Pharmaceutical Crystals with Multicomponent Crystals: Voriconazole as a Case Study

(2015) Palash Sanphui et al.   MOLECULAR PHARMACEUTICS

Cocrystals of Hydrochlorothiazide: Solubility and Diffusion/Permeability Enhancements through Drug–Coformer Interactions

(2015) Palash Sanphui et al.   MOLECULAR PHARMACEUTICS

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

(2015) Stéphane Prost et al.   NATURE

Beyond crystallography: Diffractive imaging using coherent x-ray light sources

(2015) J. Miao et al.   SCIENCE

Formulation of Liquid Propofol as a Cocrystalline Solid

(2014) Scott C. McKellar et al.   CRYSTAL GROWTH & DESIGN

Origin of Deteriorated Crystal Plasticity and Compaction Properties of a 1:1 Cocrystal between Piroxicam and Saccharin

(2014) Sayantan Chattoraj et al.   CRYSTAL GROWTH & DESIGN

Preparation and Solid-State Characterization of Dapsone Drug–Drug Co-Crystals

(2014) Linglei Jiang et al.   CRYSTAL GROWTH & DESIGN

Polymorphism in cocrystals: a review and assessment of its significance

(2014) Srinivasulu Aitipamula et al.   CRYSTENGCOMM

Baicalein–Nicotinamide Cocrystal with Enhanced Solubility, Dissolution, and Oral Bioavailability

(2014) Yanting Huang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Distinguishing between the Permeability Relationships with Absorption and Metabolism To Improve BCS and BDDCS Predictions in Early Drug Discovery

(2014) Caroline A. Larregieu et al.   MOLECULAR PHARMACEUTICS

A novel curcumin–artemisinin coamorphous solid: physical properties and pharmacokinetic profile

(2014) Kuthuru Suresh et al.   RSC Advances

Acemetacin cocrystals and salts: structure solution from powder X-ray data and form selection of the piperazine salt

(2014) Palash Sanphui et al.   IUCrJ

Designing ternary cocrystals with hydrogen bonds and halogen bonds

(2013) Srinu Tothadi et al.   CHEMICAL COMMUNICATIONS

Stabilizing vitamin D3by conformationally selective co-crystallization

(2013) Jian-Rong Wang et al.   CHEMICAL COMMUNICATIONS

Creation of Ternary Multicomponent Crystals by Exploitation of Charge-Transfer Interactions

(2013) Colin C. Seaton et al.   CHEMISTRY-A EUROPEAN JOURNAL

Andrographolide: Solving Chemical Instability and Poor Solubility by Means of Cocrystals

(2013) Kuthuru Suresh et al.   Chemistry-An Asian Journal

Temozolomide Cocrystals with Carboxamide Coformers

(2013) Palash Sanphui et al.   CRYSTAL GROWTH & DESIGN

Solubility Advantage of Tenoxicam Phenolic Cocrystals Compared to Salts

(2013) Geetha Bolla et al.   CRYSTAL GROWTH & DESIGN

Simultaneously enhancing the solubility and permeability of acyclovir by crystal engineering approach

(2013) Yan Yan et al.   CRYSTENGCOMM

Celecoxib cocrystal polymorphs with cyclic amides: synthons of a sulfonamide drug with carboxamide coformers

(2013) Geetha Bolla et al.   CRYSTENGCOMM

Odd–Even Effect in the Elastic Modulii of α,ω-Alkanedicarboxylic Acids

(2013) Manish Kumar Mishra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal Engineering of Green Tea Epigallocatechin-3-gallate (EGCg) Cocrystals and Pharmacokinetic Modulation in Rats

(2013) Adam J. Smith et al.   MOLECULAR PHARMACEUTICS

Salt and Cocrystals of Sildenafil with Dicarboxylic Acids: Solubility and Pharmacokinetic Advantage of the Glutarate Salt

(2013) Palash Sanphui et al.   MOLECULAR PHARMACEUTICS

Formulation of a Danazol Cocrystal with Controlled Supersaturation Plays an Essential Role in Improving Bioavailability

(2013) Scott L. Childs et al.   MOLECULAR PHARMACEUTICS

Systems Pharmacology of Adverse Event Mitigation by Drug Combinations

(2013) S. Zhao et al.   Science Translational Medicine

Combining piracetam and lithium salts: ionic co-crystals and co-drugs?

(2012) Dario Braga et al.   CHEMICAL COMMUNICATIONS

Crystal Engineering of Stable Temozolomide Cocrystals

(2012) N. Jagadeesh Babu et al.   Chemistry-An Asian Journal

Pharmaceutical Cocrystals of Niclosamide

(2012) Palash Sanphui et al.   CRYSTAL GROWTH & DESIGN

Polymorphs, Salts, and Cocrystals: What’s in a Name?

(2012) Srinivasulu Aitipamula et al.   CRYSTAL GROWTH & DESIGN

Fast dissolving eutectic compositions of curcumin

(2012) N. Rajesh Goud et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Improving Solubility and Pharmacokinetics of Meloxicam via Multiple-Component Crystal Formation

(2012) David R. Weyna et al.   MOLECULAR PHARMACEUTICS

A compact X-ray free-electron laser emitting in the sub-ångström region

(2012) Tetsuya Ishikawa et al.   Nature Photonics

Curcumin-Arteether Combination Therapy of Plasmodium berghei-Infected Mice Prevents Recrudescence Through Immunomodulation

(2012) Palakkod G. Vathsala et al.   PLoS One

On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin

(2012) Vincent Mascitti et al.   MedChemComm

Drug-drug co-crystals

(2012) Bhupinder Sekhon   DARU-Journal of Pharmaceutical Sciences

Atomic Pairwise Distribution Function Analysis of the Amorphous Phase Prepared by Different Manufacturing Routes

(2012) Johan P. Boetker et al.   Pharmaceutics

Editorial: The Importance of Chemistry for the Future of the Pharma Industry

(2011) Hanno Wild et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Shape and size mimicry in the design of ternary molecular solids: towards a robust strategy for crystal engineering

(2011) Srinu Tothadi et al.   CHEMICAL COMMUNICATIONS

A Tale of Two Polymorphic Pharmaceuticals: Pyrithyldione and Propyphenazone and their 1937 Co-crystal Patent

(2011) Andreas Lemmerer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fast Dissolving Curcumin Cocrystals

(2011) Palash Sanphui et al.   CRYSTAL GROWTH & DESIGN

Polymorphs and a Hydrate of Furosemide–Nicotinamide 1:1 Cocrystal

(2011) Takamitsu Ueto et al.   CRYSTAL GROWTH & DESIGN

Pyrazinamide-Diflunisal: A New Dual-Drug Co-Crystal

(2011) António O. L. Évora et al.   CRYSTAL GROWTH & DESIGN

Solubility Advantage of Amorphous Drugs and Pharmaceutical Cocrystals

(2011) N. Jagadeesh Babu et al.   CRYSTAL GROWTH & DESIGN

Ionized form of acetaminophen with improved compaction properties

(2011) Sathyanarayana Reddy Perumalla et al.   CRYSTENGCOMM

Nitrofurantoin– p ‐aminobenzoic acid cocrystal: Hydration stability and dissolution rate studies

(2011) Suryanarayan Cherukuvada et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Novel Furosemide Cocrystals and Selection of High Solubility Drug Forms

(2011) N. Rajesh Goud et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cocrystals of Quercetin with Improved Solubility and Oral Bioavailability

(2011) Adam J. Smith et al.   MOLECULAR PHARMACEUTICS

New polymorphs of isonicotinamide and nicotinamide

(2010) Jinjing Li et al.   CHEMICAL COMMUNICATIONS

Conformational and Synthon Polymorphism in Furosemide (Lasix)

(2010) N. Jagadeesh Babu et al.   CRYSTAL GROWTH & DESIGN

Understanding the relationship between crystal structure, plasticity and compaction behaviour of theophylline, methyl gallate, and their 1 : 1 co-crystal

(2010) Sayantan Chattoraj et al.   CRYSTENGCOMM

Conformational and enantiotropic polymorphism of a 1 : 1 cocrystal involving ethenzamide and ethylmalonic acid

(2010) Srinivasulu Aitipamula et al.   CRYSTENGCOMM

Crystal structure solution from experimentally determined atomic pair distribution functions

(2010) P. Juhás et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

What lies ahead

(2010)   NATURE

Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol

(2009) Shyam Karki et al.   ADVANCED MATERIALS

Solubility Advantage of Pharmaceutical Cocrystals

(2009) David J. Good et al.   CRYSTAL GROWTH & DESIGN

Pharmaceutical Cocrystals and Their Physicochemical Properties

(2009) Nate Schultheiss et al.   CRYSTAL GROWTH & DESIGN

Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs

(2009) Srinivasulu Aitipamula et al.   CRYSTENGCOMM

Dimorphs of a 1 : 1 cocrystal of ethenzamide and saccharin: solid-state grinding methods result in metastable polymorph

(2009) Srinivasulu Aitipamula et al.   CRYSTENGCOMM

Nitazoxanide Kills Replicating and NonreplicatingMycobacterium tuberculosisand Evades Resistance

(2009) Luiz Pedro S. de Carvalho et al.   JOURNAL OF MEDICINAL CHEMISTRY

Using Cocrystals To Systematically Modulate Aqueous Solubility and Melting Behavior of an Anticancer Drug

(2009) Christer B. Aakeröy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improving Mechanical Properties of Caffeine and Methyl Gallate Crystals by Cocrystallization

(2008) Changquan Calvin Sun et al.   CRYSTAL GROWTH & DESIGN

Polymorphism in Carbamazepine Cocrystals

(2008) William W. Porter III et al.   CRYSTAL GROWTH & DESIGN