HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation

HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

(2020) Peng Huang et al.   BLOOD

Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts

(2020) Eugene Khandros et al.   BLOOD

HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

(2019) Shuping Zhang et al.   eLife

A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease

(2019) Elliott Vichinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells

(2018) Yankai Zhang et al.   BLOOD

Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

(2018) Nan Liu et al.   CELL

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

(2018) Gabriella E. Martyn et al.   NATURE GENETICS

A Phase 3 Trial of l-Glutamine in Sickle Cell Disease

(2018) Yutaka Niihara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

(2018) Jeremy D. Grevet et al.   SCIENCE

Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: A SUSTAIN study analysis

(2018) Abdullah Kutlar et al.   AMERICAN JOURNAL OF HEMATOLOGY

Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa

(2018) Léon Tshilolo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease

(2017) Kenneth I. Ataga et al.   NEW ENGLAND JOURNAL OF MEDICINE

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

(2016) Elizabeth A Traxler et al.   NATURE MEDICINE

Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2

(2016) Jeffrey R. Shearstone et al.   PLoS One

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

(2016) T. Masuda et al.   SCIENCE

Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation

(2015) Erica B. Esrick et al.   AMERICAN JOURNAL OF HEMATOLOGY

Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/ -globin looping

(2015) I. Krivega et al.   BLOOD

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression

(2015) A. Renneville et al.   BLOOD

Pomalidomide reverses  -globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors

(2015) B. M. Dulmovits et al.   BLOOD

Imaging flow cytometry for automated detection of hypoxia-induced erythrocyte shape change in sickle cell disease

(2014) Eduard J. van Beers et al.   AMERICAN JOURNAL OF HEMATOLOGY

Global transcriptome analyses of human and murine terminal erythroid differentiation

(2014) X. An et al.   BLOOD

Heme-regulated eIF2  kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

(2012) R. N. V. S. Suragani et al.   BLOOD

Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib

(2012) P. G. Richardson et al.   BLOOD

Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice

(2011) S. E. Meiler et al.   BLOOD

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

(2010) James E. Bradner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pomalidomide Is Active in the Treatment of Anemia Associated With Myelofibrosis

(2009) Ayalew Tefferi et al.   JOURNAL OF CLINICAL ONCOLOGY

Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells

(2008) Laure A. Moutouh-de Parseval et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific RepressorBCL11A

(2008) Vijay G. Sankaran et al.   SCIENCE