Review
Biochemistry & Molecular Biology
Ga-Hyun Son, Jae-Jun Lee, Youngmi Kim, Keun-Young Lee
Summary: The article describes the role of antimicrobial peptides (AMPs) in preterm births (PTBs), focusing on the changes of AMPs in the development of the disease, and proposing new perspectives on the role of AMPs in PTB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yasuyuki Negishi, Yoshio Shima, Masahiko Kato, Tomoko Ichikawa, Hajime Ino, Yumi Horii, Shunji Suzuki, Rimpei Morita
Summary: Preterm birth is a common complication during pregnancy and has a significant impact on neonatal health. It can be caused by both infections and sterile inflammation. Sterile inflammation, induced by cellular damage, triggers an inflammatory response and has been associated with various pregnancy complications.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Immunology
Xia Li, Youyuan Ye, Kailan Peng, Zhuo Zeng, Li Chen, Yanhua Zeng
Summary: Histones, highly conserved in different species, serve as an ancient and universal innate host defense system against microorganisms. They act as a control switch for DNA transcription in the nucleus, but also function in the cytoplasm, cell membranes, and extracellular fluid as host defenses and inflammatory promoters. Histones can eliminate microorganisms directly and participate in phagocytes-related innate immune responses, while also playing a crucial role in epigenetic regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Xuanzhi Zhu, Hanyao Huang, Lei Zhao
Summary: Atherosclerosis is a chronic artery disease, and periodontitis is a risk factor for it. There is a molecular pathological mechanism connecting the two conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Katia Boniface, Thierry Passeron, Julien Seneschal, Meri K. Tulic
Summary: The process leading to melanocyte loss in vitiligo involves multiple factors such as environmental triggers, genetic polymorphisms, metabolic alterations, and autoimmunity. This review emphasizes on how danger signals released by stressed epidermal cells can trigger the immune system, ultimately leading to melanocyte disappearance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Heather M. Brockway, Samantha L. Wilson, Suhas G. Kallapur, Catalin S. Buhimschi, Louis J. Muglia, Helen N. Jones
Summary: Preterm birth is a global public health crisis with high mortality rates for both neonates and mothers. The molecular mechanisms of idiopathic spontaneous preterm birth are poorly understood and there are few diagnostic markers for assessing placental development and function. This study found that placental hypermaturity may play a role in idiopathic spontaneous preterm birth and identified similarities in DNA methylation patterns between idiopathic spontaneous preterm birth and term birth samples. Pathway analysis revealed differences in genes related to placental development and maturation. These findings suggest that the hypermature methylation signature in idiopathic spontaneous preterm birth samples may impact birth timing.
Article
Oncology
Casey R. Ager, Akash Boda, Kimal Rajapakshe, Spencer Thomas Lea, Maria Emilia Di Francesco, Priyamvada Jayaprakash, Ravaen B. Slay, Brittany Morrow, Rishika Prasad, Meghan A. Dean, Colm R. Duffy, Cristian Coarfa, Philip Jones, Michael A. Curran
Summary: This study demonstrates that high-potency STING agonists can repolarize suppressive myeloid populations and enhance sensitivity of pancreatic adenocarcinoma to immune checkpoint blockade therapy. The findings provide insights into the unique pathways engaged by CDNs in functional repolarization.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Antonino Palumbo, Fabiola Atzeni, Giuseppe Murdaca, Sebastiano Gangemi
Summary: Osteoarthritis (OA) is a prevalent and disabling joint disease influenced by various factors. Recent research has revealed the involvement of damage-associated molecular patterns (DAMPs), particularly alarmins like HMGB1, IL-33, and S100B, in promoting inflammation and degradation in OA chondrocytes. Identifying the molecular signaling of these molecules, their potential use as biomarkers for disease staging, and their suitability as therapeutic targets are important objectives. High levels of HMGB1, in particular, have been observed in OA cartilage, synovium, and synovial fluid, and are associated with disease severity. Strategies targeting HMGB1 have shown promising results in OA cells and animal models and could provide new treatment options for modifying disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kiyoshi Itagaki, Ingred Rica, Barbora Konecna, Hyo In Kim, Jinbong Park, Elzbieta Kaczmarek, Carl J. Hauser
Summary: Sepsis is a major public health concern, especially among trauma patients, and the pathogenesis of the disease is still not fully understood. Recent studies suggest that mitochondrial-derived damage-associated molecular patterns may play a key role in the development of SIRS/sepsis. Therefore, further research on the role of mitochondrial DAMPs in inflammatory responses and sepsis is needed.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Virology
Elona Gusho, Laimonis Laimins
Summary: Persistent infection with high-risk HPVs is a major risk factor for anogenital and oropharyngeal cancers. HPV replication depends on the activation of DNA damage repair pathways and evasion of immune surveillance. Targeting these processes with antiviral therapies may offer treatment opportunities for HPV-induced cancers.
Article
Oncology
Alan Herbert, Siddharth Balachandran
Summary: Cancer-associated fibroblasts (CAFs) are a heterogeneous population of cells that promote tumor growth. Among them, inflammatory CAFs (iCAFs) create an immunosuppressive environment but are vulnerable to cell death triggered by interferon-induced ZNA binding protein 1 (ZBP1). Exploiting this vulnerability offers new hope for improved clinical outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Julie Sarrand, Laurie Baglione, Dorian Parisis, Muhammad Soyfoo
Summary: Sjogren's syndrome is a chronic autoimmune disease that primarily affects exocrine glands. It is characterized by lymphoplasmacytic infiltration and dysfunction of the glandular tissues. In addition to dry eyes and dry mouth, patients commonly experience fatigue, pain, and other systemic symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Respiratory System
Jeremy Anderson, Lien Anh Ha Do, Danielle Wurzel, Zheng Quan Toh, Kim Mulholland, Daniel G. Pellicci, Paul Licciardi
Summary: RSV is the most common viral pathogen causing acute lower respiratory tract infection in young children. Premature birth is a common risk factor for severe RSV disease due to an immature innate immune system, leading to increased susceptibility to RSV. Understanding differences in innate immunity between preterm and term infants is crucial for developing interventions to reduce disease burden in this vulnerable population.
Review
Cell Biology
Hiroshi Ueda
Summary: Nuclear protein prothymosin α (ProTα) is a member of DAMPs/alarmins, which prevents neuronal necrosis by causing a cell death mode switch. Its extracellular release is a Ca2+-dependent process involving the formation of a protein complex and subsequent release. This non-vesicular and non-classical release mediated by ANXA2 flop-out could play key roles in DAMPs/alarmins release.
Article
Biochemistry & Molecular Biology
Ryo Amagai, Toshiya Takahashi, Hitoshi Terui, Taku Fujimura, Kenshi Yamasaki, Setsuya Aiba, Yoshihide Asano
Summary: This study aimed to determine the cellular pathways by which LL-37 amplifies inflammation induced by damage-associated molecular patterns (DAMPs). It was found that LL-37 modulates inflammation via scavenger receptors and interacts with DAMPs. The results suggest that scavenger receptors may be potential targets for treating inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Mehboob Ali, Lynette K. Rogers, Kathryn M. Heyob, Catalin S. Buhimschi, Irina A. Buhimschi
REPRODUCTIVE SCIENCES
(2019)
Article
Obstetrics & Gynecology
Terrence K. Allen, Matthew N. Nazzal, Liping Feng, Irina A. Buhimschi, Amy P. Murtha
REPRODUCTIVE SCIENCES
(2019)
Article
Obstetrics & Gynecology
Marwan Ma'ayeh, Andrea Snyder, Emily A. Oliver, Stephen E. Gee, Kara M. Rood
Summary: A secondary analysis of a large registry study found that meconium-stained amniotic fluid may be associated with an increased risk of postcesarean surgical site infections, even after adjusting for potential confounders.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Courtney A. Ware, Catalin S. Buhimschi, Guomao Zhao, Yara El Helou, Irina A. Buhimschi
Summary: IAI is associated with increased concentrations of total proteasome and immunoproteasome in amniotic fluid, with CHE-L activity of the immunoproteasome being the primary lytic activity upregulated in pregnancies complicated by IAI. Additionally, proteasome activity is highest in amniotic fluid compared to matched maternal blood and cord blood, suggesting a potential role of immunoproteasome activity in triggering preterm birth.
REPRODUCTIVE SCIENCES
(2021)
Article
Engineering, Biomedical
Mary D'Alton, Kara Rood, Hyagriv Simhan, Dena Goffman
Summary: The Jada System is a novel intrauterine vacuum-induced hemorrhage control device that provides rapid and effective treatment options for abnormal postpartum uterine bleeding and postpartum hemorrhage. Compared to currently available medications and devices, the Jada System offers significant advantages in handling obstetric emergencies.
EXPERT REVIEW OF MEDICAL DEVICES
(2021)
Article
Microbiology
Siavash Azari, Lauren J. Johnson, Amy Webb, Sophia M. Kozlowski, Xiaoli Zhang, Kara Rood, Amal Amer, Stephanie Seveau
Summary: Pregnant women are highly susceptible to infection by Listeria monocytogenes, which can lead to severe pregnancy complications. Hofbauer cells (HBCs) within the placenta play a crucial role in protecting the fetus from infection, even though they can be permissive to the replication and spread of the pathogen. Upon infection, HBCs may transition to a pro-inflammatory state while still maintaining tolerogenic factors that prevent maternal anti-fetal adaptive immunity.
Article
Obstetrics & Gynecology
Sarah Mashburn, Ellen Schleckman, Paige Cackovic, Cynthia Shellhaas, Kara M. Rood, Marwan Ma'ayeh
Summary: In this retrospective cohort study of 438 patients with intrahepatic cholestasis of pregnancy (ICP), individuals with pregestational diabetes, history of ICP, prior cholecystectomy, and tobacco use were more likely to develop severe disease. Patients with severe disease had earlier diagnosis, higher rates of gestational diabetes and hypertensive disorders of pregnancy, as well as abnormal liver enzyme levels. However, no stillbirths were observed in this cohort.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Michelle Petrich, Megan Battin, Erin Walker, Morgan Brown, Mahmoud Abdelwahab, Marwan Maayeh, Kara M. Rood
Summary: The aim of this study was to compare neonatal opioid withdrawal syndrome (NOWS) prevalence and characteristics among neonates born to women prescribed methadone and buprenorphine/naloxone. The study found that buprenorphine/naloxone treatment for OUD in pregnancy appears safe and has decreased NOWS and pharmacologic intervention for the neonate.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Gian Diaz-Rodriguez, Alexis Braverman, Gloria G. Elam, Doreen Norris-Stojak, Kathleen Harmon, Julie Hartwig, Tiana Dunlap, Heather Nixon, Phornphat Rasamimari, Irina A. Buhimschi, Catalin S. Buhimschi
Summary: Objective timely response to obstetrical emergencies is crucial, with a recommended decision-to-incision (DTI) time of not more than 30 minutes. A study was conducted to analyze the efficiency of an institutional-specific CD acuity classification system in reflecting actual DTI time, Apgar scores, and newborn acid-base status. The findings suggest that the need for neonatal resuscitation is associated with the acuity of the procedure rather than the actual DTI time.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Peripheral Vascular Disease
William E. Ackerman, Catalin S. Buhimschi, Thomas L. Brown, Guomao Zhao, Taryn L. Summerfield, Irina A. Buhimschi
Summary: By applying transcriptomics with weighted gene correlation network analysis, this study provides evidence for a molecular subphenotype consistent with a glycolytic metabolic shift in placental specimens of early-onset preeclampsia (EOPE) with or without fetal growth restriction (FGR). The identified gene group is enriched for hypoxia-response and metabolic pathways, and the expression ratios of specific genes could be used as surrogate indices for identifying this subgroup.
Editorial Material
Cardiac & Cardiovascular Systems
William E. Ackerman, Irina A. Buhimschi, Catalin S. Buhimschi
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Medical Laboratory Technology
Irina A. Buhimschi, Laura J. Frye, Beverly Winikoff, Elizabeth G. Raymond
JOURNAL OF APPLIED LABORATORY MEDICINE
(2022)
Article
Obstetrics & Gynecology
Jessica L. Pippen, Adebayo A. Adesomo, Veronica M. Gonzalez-Brown, Patrick D. Schneider, Kara M. Rood
Summary: Interrupted magnesium sulfate infusion is non-inferior to continuous infusion in terms of postpartum hemorrhage for women with severe preeclampsia undergoing cesarean delivery.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Allison L. Fisher, Veena Sangkhae, Pietro Presicce, Claire A. Chougnet, Alan H. Jobe, Suhas G. Kallapur, Sammy Tabbah, Catalin S. Buhimschi, Irina A. Buhimschi, Tomas Ganz, Elizabeta Nemeth
Article
Medicine, General & Internal
Kara M. Rood, Catalin S. Buhimschi, Theresa Dible, Shaylyn Webster, Guomao Zhao, Philip Samuels, Irina A. Buhimschi
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
