Article
Multidisciplinary Sciences
Zuxiong Tang, Jun He, Jiayue Zou, Shufei Yu, Xiaoming Sun, Lei Qin
Summary: The study found that exosomes derived from HepG2/DDP cells can transfer cisplatin resistance to HepG2 and other HCC cell lines, offering new insights into improving the effectiveness of cisplatin in treating HCC.
Article
Biochemistry & Molecular Biology
Karina Lindbog Madsen, Oke Gerke, Poul F. Hoilund-Carlsen, Birgitte Brinkmann Olsen
Summary: Cancer stem cells (CSCs) are resistant to conventional therapy and responsible for cancer relapse. Auger electron emitters show promising potential in eradicating resistant lung cancer CD44(+) populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mirza Muhammad Faran Ashraf Baig, Chengfei Zhang, Muhammad Furqan Akhtar, Ammara Saleem, Naveed Nisar
Summary: Dactinomycin (DCTM) loaded DNA-nanowires (D-NWs) were successfully synthesized through polymerization of DNA-triangles, enabling targeted drug delivery to cancer cells expressing high levels of EGFR. EGFR functionalization of D-NWs demonstrated promising potential for site-specific cancer treatment.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Saad Shaaban, Sameh M. Shabana, Yasair S. Al-Faiyz, Georg Manolikakes, Fardous F. El-Senduny
Summary: Recent research has uncovered a novel organoselenium-based pseudopeptide that shows promising efficacy in treating hepatocellular carcinoma, making cells more sensitive to cisplatin and inducing apoptosis by modulating ROS levels.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hadar Golan Berman, Pooja Chauhan, Shira Shalev, Hiba Hassanain, Avital Parnas, Sheera Adar
Summary: The study identified that in a specific cell line system, cisplatin resistant cells had less damage but similar repair kinetics. Through mapping gene expression changes, 56 upregulated genes were identified that could potentially impact the response to cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xueyu Peng, Senbiao Fang, Bin Ji, Min Li, Jie Song, Liping Qiu, Weihong Tan
Summary: This study finds that different framework nucleic acids have varying cellular uptake efficiency, and this distinction is consistent across multiple cell lines. Scavenger receptors play a crucial role in mediating the uptake process, and molecular docking simulations show that their binding depends on the corner angle of the framework nucleic acids, which determines the frequency of cellular internalization.
Article
Biochemistry & Molecular Biology
Jaemoo Chun
Summary: Isoalantolactone, a compound derived from Inula helenium L., has been identified as a potential glycolysis inhibitor to overcome cisplatin resistance in ovarian cancer. It effectively targets key glycolytic enzymes and enhances sensitivity to cisplatin-induced apoptosis. In vivo studies demonstrate its ability to suppress tumor growth in cisplatin-resistant ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Tim Moritz Weber, Alexandra Leyens, Lena Berning, Bjoern Stork, Joerg Pietruszka
Summary: This study investigated the synthesis and biological activities of Prodiginin and its derivatives. Different MBC derivatives were synthesized and tested with ligating enzymes, revealing that certain A-ring substituted prodiginines showed superior toxicity against cisplatin-resistant cancer cells. These findings contribute to the development of compounds with stronger anticancer activity against cisplatin-resistant cells.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Liujing Zhao, Weiwei Zhang, Fang Zhang
Summary: The study demonstrated that poncirin increased cisplatin sensitivity and apoptosis in cisplatin-resistant osteosarcoma cells by inhibiting the PI3K/Akt pathway and downregulating the expression of MDR1, MRP1, and BCRP.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cell Biology
Chenfei He, Shan Wang, Chikai Zhou, Minghui He, Jin Wang, Marcus Ladds, Danai Lianoudaki, Saikiran K. Sedimbi, David P. Lane, Lisa S. Westerberg, Shuijie Li, Mikael C. Karlsson
Summary: CD36 plays a critical role in regulating macro-autophagy in B cells, and its deficiency impairs the humoral immune response, leading to reduced plasma cell formation, mitochondrial mobilization, and oxidative phosphorylation. CD36 also regulates autophagy and is involved in T-cell-dependent immune responses.
Article
Biotechnology & Applied Microbiology
Disha Mittal, Largee Biswas, Anita Kamra Verma
Summary: The study aimed to sensitize cisplatin-resistant ovarian cancer cells towards cisplatin using cisplatin-loaded nanostructured lipid carriers. The results showed that the synthesized cisplatin-loaded nanostructured lipid carriers successfully enhanced the sensitivity of the resistant cancer cells by modifying reactive oxygen species levels and increasing apoptosis in the cells.
Article
Oncology
Ria Winkelmann, Katrin Bankov, Claudia Doering, Jaroslav Cinatl, Sebastian Grothe, Florian Rothweiler, Martin Michaelis, Christina Schmitt, Peter J. J. Wild, Melanie Demes, Jindrich Cinatl Jr, Stefan Vallo
Summary: In this study, a cell line with acquired resistance to chemotherapy was generated to investigate the mechanism of chemotherapy resistance in penile cancer and identify potential alternative treatments.
Article
Chemistry, Multidisciplinary
Kai Xiong, Cheng Ouyang, Jiaqi Liu, Johannes Karges, Xinlin Lin, Xiang Chen, Yu Chen, Jian Wan, Liangnian Ji, Hui Chao
Summary: This study developed highly potent G-quadruplex stabilizers, which can maintain their efficacy even under crowded cellular conditions. The stabilizers were encapsulated in DNA cages to enhance sub-cellular localization and provide cancer selectivity. The resulting nanomaterials efficiently inhibit telomerase activity in drug-resistant cancer cells and induce cell death.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Dentistry, Oral Surgery & Medicine
T. Nakano, K. A. Warner, A. E. Oklejas, Z. Zhang, C. Rodriguez-Ramirez, A. G. Shuman, J. E. Nor
Summary: This study demonstrated the therapeutic potential of mTOR inhibitors in targeting cisplatin-resistant cancer stem cells in salivary gland mucoepidermoid carcinoma. Combining mTOR inhibitors with platinum-based chemotherapy may offer a promising treatment strategy for patients with advanced MEC.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Jiawei Chen, Shuai Zhang, Liya Zhou, Xiaopeng Huang
Summary: Silver nanowire samples with different diameters and lengths were successfully synthesized using the polyol synthesis method. The size and morphology of the nanowires were controlled by changing the amount of Fe3+ ions during synthesis. The samples were characterized and used to study the effects of silver nanowires on epithelial cells and their potential mechanisms.
Article
Environmental Sciences
Shaher Bano, Ali Sharif, Bushra Akhtar, Mohamed M. Abdel-Daim, Muhammad Furqan Akhtar, Faiza Liaqat Ali
Summary: The study found that the polyphenolic components of Tamarix aphylla ethanolic extract have hepatoprotective effects against sodium arsenite-induced liver injury in rats. The extract showed high levels of phenolic and flavonoid contents and exhibited potent antioxidant activity. Treatment with the extract restored hepatic indices and oxidative markers, normalized inflammation markers, and improved histopathological findings.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Nida Shakir, Ali Sharif, Sajid Ali, Bushra Akhtar, Muhammad Furqan Akhtar, Faqir Muhammad, Ammara Saleem, Kanwal Akhtar, Imran Tariq, Muhammad Imran Khan
Summary: This study evaluated the acute and chronic toxicity of Pirarubicin loaded PLGA nanoparticles (PRB-NP). The nanoparticles did not affect the behavioral pattern, food, water consumption or body weights of the rats. The abnormalities in function and morphology of the organs produced by PRB-NP were dose-dependent and reversible.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Hafiz Saad Ahmad, Muhammad Ateeb, Sobia Noreen, Muhammad Irshad Farooq, Mirza Muhammad Faran Ashraf Baig, Muhammad Subhan Nazar, Muhammad Furqan Akhtar, Khalil Ahmad, Ali Raza Ayub, Hina Shoukat, Faheem Hadi, Asadullah Madni
Summary: The use of silver nanoparticles (AgNPs) in pharmaceutical research has significant benefits, especially AgNPs fabricated by plant extracts, which have notable effects on biological processes such as antioxidant, antibacterial, and anticancer effects. This study examined the impact of AgNPs synthesized from Dipterygium glaucum Decne. plant extract on three common human cancer cell lines. The AgNPs exhibited exceptional cytotoxicity against all cell lines in a concentration-dependent manner.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Pharmacology & Pharmacy
Razia Hanif, Muhammad Imran Khan, Asadullah Madni, Muhammad Furqan Akhtar, Muhammad Farhan Sohail, Ammara Saleem, Mubashar Rehman, Sufyan Junaid Usmani, Aslam Khan, Athar Masood
Summary: The study aimed to enhance the oral bioavailability of the poorly water-soluble drug tacrolimus by developing niosomes using polyoxyethylene lauryl ether (Brij-35) and poloxamer 407 surfactants. The niosomes were prepared using a thin film hydration technique and evaluated using various techniques including FTIR, ultra-centrifugation, DLS experiments, SEM microscopy, and DSC technique. The results showed that the newly developed niosomes can improve the dissolution profile of tacrolimus and can be considered as potential oral carriers.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Pharmacology & Pharmacy
Ammara Saleem, Izza Hameed, Muhammad Furqan Akhtar, Ghulam Md Ashraf, Badrah S. Alghamdi, Md. Habibur Rahman, Majed N. Almashjary
Summary: This research validated the folkloric use of Quercus leucotrichophora (QL) leaf extracts against inflammation and arthritis, and determined the chemical composition using HPLC. The study found that QL leaf extracts exhibited significant antioxidant, anti-inflammatory, and anti-arthritic potential, possibly due to the presence of quercetin, gallic acid, sinapic acid, and ferulic acid.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Afnan Afnan, Ammara Saleem, Muhammad Furqan Akhtar
Summary: This study aimed to evaluate the anti-inflammatory and anti-arthritic potential of Chrysin (CR), a natural dietary flavone found in plants such as Passiflora and Propalis, and honey. The results showed that treatment with CR, especially in combination with MTX, improved CFA-induced arthritis due to its significant antioxidant, analgesic, and anti-inflammatory effects.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Maira Javed, Ammara Saleem, Muhammad Furqan Akhtar
Summary: This study aimed to investigate the anti-inflammatory and anti-arthritic potential of diosgenin alone and in combination with methotrexate (MTX). The results showed that diosgenin exhibited high antioxidant and anti-arthritic activity in vitro, and showed anti-inflammatory effects by reducing inflammation and improving blood parameters in vivo. The combination of diosgenin and MTX had the best therapeutic efficacy.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Yasmin Bangash, Ammara Saleem, Muhammad Furqan Akhtar, Fareeha Anwar, Bushra Akhtar, Ali Sharif, Muhammad Imran Khan, Aslam Khan
Summary: This study found that PTN can alleviate the symptoms of atopic dermatitis by reducing inflammation, oxidative damage, and inflammatory cytokine expression in the skin of diseased animals. Therefore, PTN may be an effective drug for treating atopic dermatitis and other inflammatory skin disorders.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Amna Tahir, Muhammad Furqan Akhtar, Ammara Saleem, Muhammad Naveed, Basiru Olaitan Ajiboye, Fareeha Anwar, Aslam Khan
Summary: PCCR is a traditional herbal medicine used for treating muscular swelling, inflammation, pain, and fever. This study confirmed the anti-inflammatory, analgesic, and neuroprotective effects of PCCR in arthritic rats. PCCR exhibited antioxidant and anti-inflammatory activities, improved oxidative stress, and reduced inflammatory markers in rats with arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Oncology
Hafiz Muhammad Zubair, Muhammad Arslan Khan, Faisal Gulzar, Musaed Alkholief, Abdul Malik, Suhail Akhtar, Ali Sharif, Muhammad Furqan Akhtar, Muhammad Abbas
Summary: This study aims to explore the experiences of NSCLC patients receiving palliative chemotherapy and their adaptation to post-chemotherapy life, beliefs, and quality of life. Through face-to-face interviews, the patients' experiences were categorized into five themes, revealing the importance of shared decision-making between clinicians and patients.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Plant Sciences
Sana Saleem, Fareeha Anwar, Aslam Khan, Uzma Saleem, Muhammad Furqan Akhtar, Irum Shahzadi, Tariq Ismail
Summary: This study aimed to detect any hazardous effects of B. aurea on animals and find out its LD50. The results revealed no mortality and morbidity in both acute oral and sub-acute toxicity studies. However, oxidative stress markers were significantly increased in the treatment groups, and animals showed decreased food and water intake in the acute oral toxicity study. A slight difference in renal function tests was observed, but no significant change in histopathology was found in selected organs. This study concluded that B. aurea can be safely used for pharmacological purposes.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Moonis Shoaib, Ammara Saleem, Alam Zeb, Muhammad Imran Khan, Muhammad Furqan Akhtar
Summary: This study evaluated the therapeutic effect of Centratherum anthelminticum seed extract (CA) against polycystic ovary syndrome (PCOS) in rats. The results showed that CA effectively reduced cholesterol and triglyceride levels, normalized hormone levels, improved insulin resistance, reduced inflammation, and enhanced antioxidant activity. Histopathological examination also revealed a normal follicular development in CA-treated rats. Overall, CA demonstrated antidiabetic, anti-inflammatory, antihyperlipidemic, and antioxidant properties in treating PCOS.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Oncology
Muhammad Sarfraz, Abida Khan, Gaber El-Saber Batiha, Muhammad Furqan Akhtar, Ammara Saleem, Basiru Olaitan Ajiboye, Mehnaz Kamal, Abuzer Ali, Nawaf M. Alotaibi, Shams Aaghaz, Muhammad Irfan Siddique, Mohd Imran
Summary: Mangiferin, derived from Mangifera indica L., has shown potential as an anticancer agent. Researchers have explored its effects on breast cancer cells through in vitro and in vivo models. However, its low solubility and bioavailability have posed challenges, prompting the use of nanotechnology-based drug delivery systems to enhance its efficacy and safety.
Article
Environmental Sciences
Sadaf Yasmeen, Aslam Khan, Fareeha Anwar, Muhammad Furqan Akhtar, Sidra Yasmeen, Shafeeq Ali Shah
Summary: This study aimed to examine the antifibrotic effect of direct-acting antiviral drugs Sofosbuvir and Velpatasvir in a rat model of carbon tetrachloride-induced fibrosis. The results showed that Sofosbuvir and Velpatasvir, alone or in combination, significantly inhibited fibrosis and mediated this effect by reducing the levels of TNF-a/NF-& kappa;B and the IL-6 signaling pathway. Therefore, Sofosbuvir and Velpatasvir may have antifibrotic effects independent of their antiviral activity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, General & Internal
Ummara Altaf, Zikria Saleem, Muhammad Furqan Akhtar, Waleed Mohammad Altowayan, Abdulmajeed A. Alqasoumi, Mohammed Salem Alshammari, Abdul Haseeb, Fahad Raees, Mohammad Tarique Imam, Narjis Batool, Muhammad Masoom Akhtar, Brian Godman
Summary: Culture sensitivity reports were used in a teaching hospital in Pakistan to optimize antibiotic prescribing. The adjustment of empiric therapy based on the reports led to a reduction in antibiotic utilization and costs, as well as improved treatment selection. The study highlights the importance of implementing antimicrobial stewardship programs and hospital antibiotic guidelines to minimize unnecessary use of broad-spectrum antibiotics.
MEDICINA-LITHUANIA
(2023)