Article
Biochemistry & Molecular Biology
Amel Bouzabata, Paola Montoro, Katarzyna Angelika Gil, Sonia Piacente, Fadia S. Youssef, Nawal M. Al Musayeib, Geoffrey A. Cordell, Mohamed L. Ashour, Carlo Ignazio Giovanni Tuberoso
Summary: This study evaluated the phenolic content and antioxidant activity of different parts of Echinops spinosus L. from northeast Algeria. The results showed that caffeoyl quinic derivatives were the most abundant compounds, and the root extract exhibited the highest antioxidant activity. Molecular docking study also revealed potential bioactive components.
Article
Biochemistry & Molecular Biology
Dongxiao Ma, Zhengchao Ji, Haiwei Cao, Jing Huang, Lei Zeng, Lei Yin
Summary: This study developed a detection method based on HPLC/MS3 strategy for quantifying carbamazepine in human plasma. The method was validated for various parameters and showed good accuracy, precision, and selectivity. It was successfully used for monitoring the blood concentration of epilepsy patients after carbamazepine treatment.
Article
Plant Sciences
Stefania Sut, Mario Malagoli, Stefano Dall'Acqua
Summary: This study evaluated the influences of silicon foliar application on berry composition in four grapevine cultivars. Results showed that silicon induced cultivar specific changes in berry composition, such as significant increase in anthocyanins in Oseleta cultivar, increased proline levels in Garganega, and decreased tartaric acid in Chardonnay.
Article
Chemistry, Medicinal
Amine Elbouzidi, Mohamed Taibi, Hayat Ouassou, Sabir Ouahhoud, Douaae Ou-Yahia, El Hassania Loukili, Marouane Aherkou, Farid Mansouri, Noureddine Bencheikh, Salah Laaraj, Reda Bellaouchi, Ennouamane Saalaoui, Kaoutar Elfazazi, Abdelbasset Berrichi, Malika Abid, Mohamed Addi
Summary: The study investigates the antioxidant, antimicrobial, and cytotoxic properties of the ethanolic extract of Carob tree leaves. The extract exhibited potent antioxidant activity and broad-spectrum antibacterial properties. It also showed dose-dependent inhibitory activity against human breast cancer cell lines. However, it had only moderate activity against fungal strains and resulted in genotoxic effects at high concentrations.
Review
Plant Sciences
Malgorzata Chrzaszcz, Barbara Krzeminska, Rafal Celinski, Katarzyna Szewczyk
Summary: The genus Cephalaria is a rich source of interesting secondary metabolites, mainly saponins, flavonoids, and phenolic acids. This genus is utilized in traditional medicine for various ailments and exhibits antioxidative activity. Future research should focus on in vitro and in vivo studies, as well as clinical trials, to confirm the potential use of these plants as natural antioxidants.
Article
Biochemistry & Molecular Biology
Niwana Wangsawat, Lutfun Nahar, Satyajit D. Sarker, Cherdchai Phosri, Andrew R. Evans, Anthony J. S. Whalley, Kiattawee Choowongkomon, Nuttika Suwannasai
Summary: Xylaria species associated with termite nests or soil are rare in nature, but have been found to be a rich source of bioactive metabolites. These fungi exhibit strong antioxidant activity and cytotoxicity, with potential therapeutic properties that warrant further exploration.
Article
Biochemistry & Molecular Biology
Mariem Saada, Hanen Wasli, Ines Jallali, Rim Kboubi, Karl Girard-Lalancette, Vakhtang Mshvildadze, Riadh Ksouri, Jean Legault, Susana M. Cardoso
Summary: The methanolic extract of Retama raetam was fractionated into four fractions, with F3 showing the most promising antioxidant and cytotoxic abilities, F1 exhibiting potential in inhibiting alpha-amylase, and F4 being the most active against tested bacteria. This highlights the distinct biological potentials of purified fractions of Retama raetam.
Article
Biochemistry & Molecular Biology
Laura Gamboa-Carvajal, Carlos Jara-Gutierrez, Joan Villena, Lautaro Taborga, Jairo Rene Martinez, Luis Espinoza, Elena E. Stashenko
Summary: In this study, the antioxidant and cytotoxic activities of hydro-ethanolic extracts from different parts of Steiractinia aspera Cuatrec, both fresh and post-distillation, were evaluated. The fresh leaf extract showed the highest antioxidant activity, while the post-distillation leaf extract exhibited the highest cytotoxicity.
Article
Biotechnology & Applied Microbiology
Fernanda Barroso Peixoto, Ana Caroline Raimundini Aranha, Rafael Oliveira Defendi, Lilian Tatiani Dusman Tonin, Caroline Casagrande Sipoli, Agatha Giovanna Fragoso, Elisangela Dusman, Rubia Michele Suzuki
Summary: This study aimed to optimize the extraction process of bioactive compounds with antiproliferative activity from goji berry and evaluate the extraction kinetic models. The results showed that ultrasound extraction method had the highest antioxidant activity and compound concentrations. The extract also demonstrated cytotoxic effects on human hepatoma cells.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jana Orsavova, Irena Sytarova, Jiri Mlcek, Ladislava Misurcova
Summary: This study evaluates the impact of climatic conditions on the chemical composition and antioxidant activity of honeysuckle berries in two different areas. The results showed that the chemical composition and antioxidant activity varied depending on the cultivars, locality, and selected methods. Berries from the area with more sunshine had higher levels of certain compounds, while berries from the area with more rain had higher levels of other compounds. The findings can help in selecting the most valuable cultivars for producers and consumers.
Article
Chemistry, Analytical
Ozlem Kilic Buyukkurt, Gamze Guclu, Celaleddin Barutcular, Serkan Selli, Hasim Kelebek
Summary: This study investigated the phenolic compounds, total phenolic content, antioxidant activity, and color properties of fresh petals from three important Turkish safflower cultivars. The results showed that the Gokturk cultivar had higher phenolic content, total phenolics, and antioxidant activity compared to the Dincer and Balci cultivars. The study also identified two compounds for the first time in safflower petals, highlighting significant variations among the cultivars in terms of phenolic profiles, antioxidant activities, and color properties.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Applied
Sara Saeed Kotb, Iriny M. Ayoub, Safaa A. El-Moghazy, Abdel Nasser B. Singab
Summary: The metabolites profile of Egyptian P. dulce bark, rich in polyphenols and flavonoids, was analyzed using UPLC-ESI-MS/MS. The bark showed promising antioxidant and cytotoxic activities, but weak antimicrobial activity. In silico molecular docking study revealed good interaction energy between daidzein compound and the target protein.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Guillermo Schmeda-Hirschmann, Javier Antileo-Laurie, Cristina Theoduloz, Felipe Jimenez-Aspee, Felipe Avila, Alberto Burgos-Edwards, Veronica Olate-Olave
Summary: The study found that the phenolic-enriched extracts from Araucaria araucana kernels have positive effects on antioxidant capacity, inhibitory activity on metabolic syndrome-associated enzymes, and reduction of postprandial oxidative stress. Traditional processing increases the flavan-3-ol content, indicating potential health-promoting properties of this traditional food.
Article
Pharmacology & Pharmacy
Esra Eroglu Ozkan, Ezgi Ersoy, Yeter Yesil Canturk, Emel Mataraci Kara, Ercan Cinar, Hasan Sahin, Selim Karahan, Kubra Karaca Sancaktepe, Mustafa Abdullah Yilmaz, Mehmet Boga
Summary: Thyme has been traditionally used for therapeutic purposes in various cultures. This study investigated three Thymus species from Turkey, finding high antioxidant and antimicrobial activities in all extracts.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qiang Sun, Haiwei Cao, Yong Liu, Yanyan Li, Jing Huang
Summary: A simple sample preprocessing method was developed for the quantitative determination of amantadine in human plasma using LC-MS3. The method showed high selectivity and sensitivity, and met the validation requirements of FDA.
Article
Chemistry, Applied
Danuta Sobolewska, Agnieszka Galanty, Sebastian Granica, Irma Podolak, Monika Anna Olszewska, Aleksandra Owczarek, Niraldo Paulino, Klaudia Michalska
Summary: This study reports on the cytotoxic activity of the methanolic extract and fractions of Cuphea ingrata against human skin and prostate cancer cells. The ethyl acetate fraction showed the highest activity against human skin cancer cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Environmental Sciences
Adam Krusinski, Anna Grzywa-Celinska, Luiza Grzycka-Kowalczyk, Rafal Celinski, Katarzyna Dos Santos Szewczyk
Summary: This study aimed to assess the relationship between objective radiological features and laboratory tests of fluid collected by thoracocentesis in patients with pneumonia or lung cancer. The results showed that lung cancer patients had significantly lower Hounsfield units and pH values in pleural fluid compared to pneumonia patients.
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Horticulture
Malgorzata Chrzaszcz, Katarzyna Dos Santos Szewczyk, Agnieszka Dabrowska, Dorota Tchorzewska
Summary: This study conducted a comparative analysis of the morphological and anatomical structures of Knautia drymeia and K. macedonica, as well as the distribution of polyphenolic compounds in these species. It found that both species had similar morphological, anatomical, and histological structures, and polyphenolic compounds were mainly accumulated in the parenchyma tissue, particularly in the leaves. The study integrated morphological/histological analyses with investigations of the biotechnological/pharmaceutical potential of the studied plants, presenting an innovative and holistic approach to the current research problem.
ACTA SCIENTIARUM POLONORUM-HORTORUM CULTUS
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Chrzaszcz, Malgorzata Miazga-Karska, Katarzyna Klimek, Michal P. Dybowski, Rafal Typek, Dorota Tchorzewska, Katarzyna Dos Santos Szewczyk
Summary: English Summary: This study evaluated the antioxidant, anti-inflammatory, antibacterial, and cytotoxic activities of the extracts and fractions of two unstudied Knautia species, K. drymeia and K. macedonica. LC-MS analysis revealed the presence of 47 compounds belonging to flavonoids and phenolic acids in both species, while GC-MS analysis identified mainly sugar derivatives, phytosterols, and fatty acids and their esters. The ethanol and methanol-acetone-water extracts of K. drymeia showed strong free radical scavenging ability, inhibition of cyclooxygenase-1, cyclooxygenase-2, and lipoxygenase, low minimal inhibitory concentration against acne strains, and non-toxicity towards normal skin fibroblasts. In conclusion, K. drymeia extracts are promising and safe agents for further biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Nurzynska, Katarzyna Klimek, Agnieszka Michalak, Katarzyna Dos Santos Szewczyk, Marta Arczewska, Urszula Szalaj, Mariusz Gagos, Grazyna Ginalska
Summary: This study aimed to evaluate the potential of biomaterials based on curdlan, a natural biopolymer, modified with hop compounds for promoting skin wound healing. The results showed that these biomaterials had excellent biocompatibility and wound healing-promoting properties without cytotoxic effects on cells and tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Maciej Korczak, Maciej Pilecki, Sebastian Granica, Aleksandra Gorczynska, Karolina A. Pawlowska, Jakub P. Piwowarski
Summary: Clinical research has identified promising herbal medicines for the treatment of mild mood disorders, but the active constituents are still unclear. The role of the microbiota-gut-brain axis offers new possibilities for treatment and prevention.
Article
Plant Sciences
Marek Gogacz, Jerzy Peszke, Dorota Natorska-Chomicka, Monika Ruszala, Katarzyna Dos Santos Szewczyk
Summary: Propolis and its extracts have a wide range of biological activities. A new cold separation method was used to obtain qualitatively better propolis extracts, containing chemical compounds that are absent in extracts obtained using high-temperature methods. The biological activity of these extracts against breast cancer cell lines was evaluated, and the results showed cytotoxicity against the cancer cells and potential application as health-promoting supplements.
Review
Biochemistry & Molecular Biology
Ewelina Rostkowska, Ewa Poleszak, Katarzyna Wojciechowska, Katarzyna Dos Santos Szewczyk
Summary: This paper focuses on the management of aged skin in dermatology. Through literature research, the basic techniques and preparations used by dermatologists in treating aged skin are presented. The paper discusses the treatments for skin diseases and cosmetic treatments related to skin care.
Article
Multidisciplinary Sciences
Katarzyna Dos Santos Szewczyk, Weronika Skowronska, Aleksandra Kruk, Anna Makuch-Kocka, Anna Bogucka-Kocka, Malgorzata Miazga-Karska, Anna Grzywa-Celinska, Sebastian Granica
Summary: The composition of extracts from the roots and leaves of Eutrema japonicum cultivated in Poland were evaluated using LC-DAD-IT-MS and LC-Q-TOF-MS analyses. The results identified forty-two constituents, including glycosinolates, phenylpropanoid glycosides, flavone glycosides, hydroxycinnamic acids, and other compounds. The extracts were then tested for their cytotoxic effect, impact on probiotic and intestinal pathogenic strains, and anti-inflammatory activity. The 60% ethanol extract from biennial roots (WR2) exhibited the strongest anti-inflammatory, antibacterial, and cytotoxic activities. These findings suggest that E. japonicum extracts have potential as health-promoting supplements.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Oleh Koshovyi, Inna Vlasova, Heleriin Laur, Ganna Kravchenko, Oksana Krasilnikova, Sebastian Granica, Jakub P. Piwowarski, Jyrki Heinamaki, Ain Raal
Summary: The study investigates the chemical composition and potential insulin resistance correction effect of American cranberry leaf extracts. The findings suggest that these extracts have a positive effect on insulin sensitivity coefficients and liver lipid content, making them a potential preventive measure against health issues associated with insulin resistance. Additionally, a novel 3D-printed oral dosage form has been developed for easy administration of the extracts.
Article
Pharmacology & Pharmacy
Rasmus Bandick, Lia V. Busmann, Soraya Mousavi, Nizar W. Shayya, Jakub P. Piwowarski, Sebastian Granica, Matthias F. Melzig, Stefan Bereswill, Markus M. Heimesaat
Summary: This study investigated the disease-alleviating effects of menthol and various plant extracts in acute campylobacteriosis. The combination of these compounds alleviated diarrhea symptoms and reduced colonic T cell numbers in infected mice. However, it did not affect gastrointestinal pathogen loads or extra-intestinal immune responses.
Article
Medicine, Research & Experimental
Maciej Korczak, Piotr Roszkowski, Weronika Skowronska, Klaudia M. Zoldak, Dominik Popowski, Sebastian Granica, Jakub P. Piwowarski
Summary: Urolithin A is a promising health-boosting agent that promotes mitophagy, improves skeletal muscle function, and suppresses the inflammatory response. By synthesizing new derivatives of urolithin conjugated with nonsteroidal anti-inflammatory drugs, its activity can be enhanced and intestinal metabolism can be improved.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
