Journal
ANTIOXIDANTS
Volume 9, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/antiox9080767
Keywords
meso-zeaxanthin; zeaxanthin; lutein; carotenoid diacetates; bioavailability; micromicelles
Funding
- Howard Foundation UK [285822]
- Waterford Institute of Technology (WIT)
- Industrial Organica, Mexico
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Lutein (L), zeaxanthin (Z), andmeso-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (p< 0.001 top= 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (p= 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561).
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