Resident Memory T Cells and Their Effect on Cancer

TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials

(2020) Khalil Choucair et al.   CANCER GENE THERAPY

Efficacy and Safety of Avelumab for Patients With Recurrent or Refractory Ovarian Cancer

(2019) Mary L. Disis et al.   JAMA Oncology

A randomised phase II study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple negative breast cancer – clinical results and biomarker analysis of GeparNuevo study

(2019) S Loibl et al.   ANNALS OF ONCOLOGY

Location, location, location: Tissue resident memory T cells in mice and humans

(2019) Peter A. Szabo et al.   Science Immunology

Tissue-Resident Memory T Cells in Cancer Immunosurveillance

(2019) Simone L. Park et al.   TRENDS IN IMMUNOLOGY

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Tissue-resident memory T cells are epigenetically cytotoxic with signs of exhaustion in human urinary bladder cancer

(2018) Ciputra Adijaya Hartana et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD103+Tumor-Resident CD8+T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti–PD-1 Treatment

(2018) Jarem Edwards et al.   CLINICAL CANCER RESEARCH

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

(2018) Peter Savas et al.   NATURE MEDICINE

A Systematic Review: The Role of Resident Memory T Cells in Infectious Diseases and Their Relevance for Vaccine Development

(2018) Visai Muruganandah et al.   Frontiers in Immunology

Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma

(2018) Felipe Gálvez-Cancino et al.   OncoImmunology

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Targeting Resident Memory T Cells for Cancer Immunotherapy

(2018) Charlotte Blanc et al.   Frontiers in Immunology

Tumor Resident Memory T Cells: New Players in Immune Surveillance and Therapy

(2018) Nina Dumauthioz et al.   Frontiers in Immunology

Resident memory T cells, critical components in tumor immunology

(2018) Fathia Mami-Chouaib et al.   Journal for ImmunoTherapy of Cancer

Pembrolizumab monotherapy for previously untreated, PD-L1-positive, metastatic triple-negative breast cancer: cohort B of the phase II KEYNOTE-086 study

(2018) S Adams et al.   ANNALS OF ONCOLOGY

Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort A of the phase II KEYNOTE-086 study

(2018) S Adams et al.   ANNALS OF ONCOLOGY

Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin

(2018) Simone L. Park et al.   NATURE

Tissue-resident memory T cells populate the human brain

(2018) Joost Smolders et al.   Nature Communications

Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse?

(2018) Karin Steinbach et al.   Frontiers in Immunology

Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment

(2018) Chunmei Fu et al.   Frontiers in Immunology

Cytotoxic tumour-infiltrating T lymphocytes influence outcome in resected pancreatic ductal adenocarcinoma

(2017) Philipp Lohneis et al.   EUROPEAN JOURNAL OF CANCER

Adenovirus vector-based prime-boost vaccination via heterologous routes induces cervicovaginal CD8+ T cell responses against HPV16 oncoproteins

(2017) Nicolas Çuburu et al.   INTERNATIONAL JOURNAL OF CANCER

IL-2hightissue-resident T cells in the human liver: Sentinels for hepatotropic infection

(2017) Laura J. Pallett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

(2017) Youdong Pan et al.   NATURE

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

(2017) J. Justin Milner et al.   NATURE

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

(2017) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

(2017) Michel Enamorado et al.   Nature Communications

Induction of resident memory T cells enhances the efficacy of cancer vaccine

(2017) Mevyn Nizard et al.   Nature Communications

Prognostic implications of intratumoral CD103+ tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma

(2017) Jaemoon Koh et al.   Oncotarget

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

(2017) Fenne L. Komdeur et al.   OncoImmunology

CD103 and Intratumoral Immune Response in Breast Cancer

(2016) Z.-Q. Wang et al.   CLINICAL CANCER RESEARCH

Phase II study of Vigil® DNA engineered immunotherapy as maintenance in advanced stage ovarian cancer

(2016) Jonathan Oh et al.   GYNECOLOGIC ONCOLOGY

A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures

(2016) Michael Thomas Wong et al.   IMMUNITY

New Strategies for the Treatment of Solid Tumors with CAR-T Cells

(2016) Hao Zhang et al.   International Journal of Biological Sciences

Progesterone Levels Associate with a Novel Population of CCR5+CD38+CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential

(2016) Alison Swaims-Kohlmeier et al.   JOURNAL OF IMMUNOLOGY

Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung

(2016) K M Morabito et al.   Mucosal Immunology

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy

(2016) Fenne L. Komdeur et al.   Oncotarget

Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs

(2016) Heng Giap Woon et al.   PLoS Pathogens

Very Late Antigen-1 Marks Functional Tumor-Resident CD8 T Cells and Correlates with Survival of Melanoma Patients

(2016) Timothy Murray et al.   Frontiers in Immunology

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell-Mediated Tumor Control in the Genital Tract

(2015) Y.-Y. Sun et al.   CLINICAL CANCER RESEARCH

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor

(2015) James N. Kochenderfer et al.   JOURNAL OF CLINICAL ONCOLOGY

CD8+CD103+Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients

(2015) Fayçal Djenidi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention

(2015) Laura K. Mackay et al.   JOURNAL OF IMMUNOLOGY

Pilot Trial of FANG Immunotherapy in Ewing's Sarcoma

(2015) Maurizio Ghisoli et al.   MOLECULAR THERAPY

PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian Cancer

(2015) J. R. Webb et al.   Cancer Immunology Research

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

Prognostic Value of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancers From Two Phase III Randomized Adjuvant Breast Cancer Trials: ECOG 2197 and ECOG 1199

(2014) Sylvia Adams et al.   JOURNAL OF CLINICAL ONCOLOGY

Topical Herpes Simplex Virus 2 (HSV-2) Vaccination with Human Papillomavirus Vectors Expressing gB/gD Ectodomains Induces Genital-Tissue-Resident Memory CD8+T Cells and Reduces Genital Disease and Viral Shedding after HSV-2 Challenge

(2014) Nicolas Çuburu et al.   JOURNAL OF VIROLOGY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory

(2014) A. Okhrimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

(2014) J. M. Schenkel et al.   SCIENCE

Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert

(2014) S. Ariotti et al.   SCIENCE

Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure

(2014) Milas Ugur et al.   Nature Communications

Reprogramming Tumor-Infiltrating Dendritic Cells for CD103+CD8+ Mucosal T-cell Differentiation and Breast Cancer Rejection

(2014) T.-C. Wu et al.   Cancer Immunology Research

Characterization and Functional Properties of Gastric Tissue-Resident Memory T Cells from Children, Adults, and the Elderly

(2014) Jayaum S. Booth et al.   Frontiers in Immunology

Tumor-Infiltrating Lymphocytes Expressing the Tissue Resident Memory Marker CD103 Are Associated with Increased Survival in High-Grade Serous Ovarian Cancer

(2013) J. R. Webb et al.   CLINICAL CANCER RESEARCH

Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer

(2013) Satoshi Wada et al.   Journal of Translational Medicine

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors

(2013) F. Sandoval et al.   Science Translational Medicine

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

(2012) Scott N. Mueller et al.   Annual Review of Immunology

Recirculating Memory T Cells Are a Unique Subset of CD4+ T Cells with a Distinct Phenotype and Migratory Pattern

(2012) S. K. Bromley et al.   JOURNAL OF IMMUNOLOGY

Phase I Trial of “bi-shRNAifurin/GMCSF DNA/Autologous Tumor Cell” Vaccine (FANG) in Advanced Cancer

(2011) Neil Senzer et al.   MOLECULAR THERAPY

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

(2009) Fernando Cruz-Guilloty et al.   JOURNAL OF EXPERIMENTAL MEDICINE