The Spindle-Associated Microcephaly Protein, WDR62, Is Required for Neurogenesis and Development of the Hippocampus

Genetic compensation triggered by mutant mRNA degradation

(2019) Mohamed A. El-Brolosy et al.   NATURE

Two Novel Mutations (c.883-4_890del and c.1684C>G) of WDR62 Gene Associated With Autosomal Recessive Primary Microcephaly: A Case Report

(2019) You Gyoung Yi et al.   Frontiers in Pediatrics

The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development

(2019) Belal Shohayeb et al.   HUMAN MOLECULAR GENETICS

The Genetics of Primary Microcephaly

(2018) Divya Jayaraman et al.   Annual Review of Genomics and Human Genetics

A novel non sense mutation in WDR62 causes autosomal recessive primary microcephaly: a case report

(2018) Imane Cherkaoui Jaouad et al.   BMC Medical Genetics

Cell-Biological Requirements for the Generation of Dentate Gyrus Granule Neurons

(2018) Maryam Hatami et al.   Frontiers in Cellular Neuroscience

The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development

(2017) Belal Shohayeb et al.   MOLECULAR NEUROBIOLOGY

Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly

(2017) Paraskevi Sgourdou et al.   Scientific Reports

Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth

(2017) Nicholas R. Lim et al.   Stem Cell Reports

Abnormal spindle-like microcephaly-associated (ASPM) mutations strongly disrupt neocortical structure but spare the hippocampus and long-term memory

(2016) Sandrine Passemard et al.   CORTEX

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate

(2016) Divya Jayaraman et al.   NEURON

The Microcephaly-Associated Protein Wdr62/CG7337 Is Required to Maintain Centrosome Asymmetry in Drosophila Neuroblasts

(2016) Anjana Ramdas Nair et al.   Cell Reports

Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation

(2015) Nicholas R. Lim et al.   CELL CYCLE

Centrosome dynamics as a source of chromosomal instability

(2015) Hyun-Ja Nam et al.   TRENDS IN CELL BIOLOGY

Development of the adult neurogenic niche in the hippocampus of mice

(2015) Zeina Nicola et al.   Frontiers in Neuroanatomy

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

(2015) Andrew Kodani et al.   eLife

Cellular dynamics of neuronal migration in the hippocampus

(2015) Kanehiro Hayashi et al.   Frontiers in Neuroscience

Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules

(2014) N. R. Lim et al.   JOURNAL OF CELL SCIENCE

Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size

(2014) Jian-Fu Chen et al.   Nature Communications

Microcephaly-Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the Developing Neocortex

(2014) Dan Xu et al.   Cell Reports

Abnormal centrosome and spindle morphology in a patient with autosomal recessive primary microcephaly type 2 due to compound heterozygous WDR62 gene mutation

(2013) Heba Farag et al.   Orphanet Journal of Rare Diseases

CDK5RAP2 Expression During Murine and Human Brain Development Correlates with Pathology in Primary Autosomal Recessive Microcephaly

(2012) Lina Issa et al.   CEREBRAL CORTEX

Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus

(2012) T. Iwano et al.   DEVELOPMENT

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

(2012) M. A. Bogoyevitch et al.   JOURNAL OF CELL SCIENCE

Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome

(2012) Rebecca E. McIntyre et al.   PLoS Genetics

Autosomal recessive primary microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum

(2011) Saqib Mahmood et al.   Orphanet Journal of Rare Diseases

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

(2010) Kaya Bilgüvar et al.   NATURE

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

(2010) Timothy W Yu et al.   NATURE GENETICS

WDR62 is associated with the spindle pole and is mutated in human microcephaly

(2010) Adeline K Nicholas et al.   NATURE GENETICS

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

A Novel c-Jun N-terminal Kinase (JNK)-binding Protein WDR62 Is Recruited to Stress Granules and Mediates a Nonclassical JNK Activation

(2009) Tanya Wasserman et al.   MOLECULAR BIOLOGY OF THE CELL

Specific Glial Populations Regulate Hippocampal Morphogenesis

(2008) G. Barry et al.   JOURNAL OF NEUROSCIENCE