The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development

WDR62 overexpression is associated with a poor prognosis in patients with lung adenocarcinoma

(2017) Kazuya Shinmura et al.   MOLECULAR CARCINOGENESIS

Autosomal Recessive Primary Microcephaly (MCPH): An Update

(2017) Deborah Morris-Rosendahl et al.   NEUROPEDIATRICS

Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly

(2017) Paraskevi Sgourdou et al.   Scientific Reports

WDR62 Regulates Early Neural and Glial Progenitor Specification of Human Pluripotent Stem Cells

(2017) Abdullah J. Alshawaf et al.   Stem Cells International

CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development

(2017) Sami Zaqout et al.   Stem Cell Reports

Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth

(2017) Nicholas R. Lim et al.   Stem Cell Reports

Ribonucleoprotein bodies are phased in

(2016) Aristeidis P. Sfakianos et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Novel splice-site mutation inWDR62revealed by whole-exome sequencing in a Sudanese family with primary microcephaly

(2016) Fatma Bastaki et al.   CONGENITAL ANOMALIES

A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development

(2016) Feng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate

(2016) Divya Jayaraman et al.   NEURON

Novel mutations c.28G>T (p.Ala10Ser) and c.189G>T (p.Glu63Asp) in WDR62 associated with early onset acanthosis and hyperkeratosis in a patient with autosomal recessive microcephaly type 2

(2016) Santasree Banerjee et al.   Oncotarget

The Microcephaly-Associated Protein Wdr62/CG7337 Is Required to Maintain Centrosome Asymmetry in Drosophila Neuroblasts

(2016) Anjana Ramdas Nair et al.   Cell Reports

Novel splice-site mutation inWDR62revealed by whole-exome sequencing in a Sudanese family with primary microcephaly

(2016) Fatma Bastaki et al.   CONGENITAL ANOMALIES

Molecular Identity of Human Outer Radial Glia during Cortical Development

(2015) Alex A. Pollen et al.   CELL

Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation

(2015) Nicholas R. Lim et al.   CELL CYCLE

What next-generation sequencing (NGS) technology has enabled us to learn about primary autosomal recessive microcephaly (MCPH)

(2015) Deborah J. Morris-Rosendahl et al.   MOLECULAR AND CELLULAR PROBES

CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination

(2015) Marko Marjanović et al.   Nature Communications

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

(2015) Andrew Kodani et al.   eLife

Severe presentation ofWDR62mutation: Is there a role for modifying genetic factors?

(2014) Cathryn J. Poulton et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A novel single base pair duplication in WDR62 causes primary microcephaly

(2014) Verena Rupp et al.   BMC Medical Genetics

Neural progenitors, neurogenesis and the evolution of the neocortex

(2014) M. Florio et al.   DEVELOPMENT

Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules

(2014) N. R. Lim et al.   JOURNAL OF CELL SCIENCE

Cortical neurogenesis in the absence of centrioles

(2014) Ryan Insolera et al.   NATURE NEUROSCIENCE

Primary cilia are required in a unique subpopulation of neural progenitors

(2014) C. K. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell decisions: A twist of fate or a niche market?

(2014) Jens Januschke et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size

(2014) Jian-Fu Chen et al.   Nature Communications

Microcephaly-Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the Developing Neocortex

(2014) Dan Xu et al.   Cell Reports

Investigating microcephaly

(2013) C. G. Woods et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Asymmetric Inheritance of Centrosome-Associated Primary Cilium Membrane Directs Ciliogenesis after Cell Division

(2013) Judith T.M.L. Paridaen et al.   CELL

WD40 repeat-containing 62 overexpression as a novel indicator of poor prognosis for human gastric cancer

(2013) Shan Zeng et al.   EUROPEAN JOURNAL OF CANCER

Identification and Analysis of a Novel Dimerization Domain Shared by Various Members of c-Jun N-terminal Kinase (JNK) Scaffold Proteins

(2013) Ksenya Cohen-Katsenelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation

(2013) Holden Higginbotham et al.   NATURE NEUROSCIENCE

Abnormal centrosome and spindle morphology in a patient with autosomal recessive primary microcephaly type 2 due to compound heterozygous WDR62 gene mutation

(2013) Heba Farag et al.   Orphanet Journal of Rare Diseases

Overexpression of WDR62 is associated with centrosome amplification in human ovarian cancer

(2013) Yu Zhang et al.   Journal of Ovarian Research

Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression

(2013) C. Novorol et al.   Open Biology

Genetic heterogeneity in Pakistani microcephaly families

(2012) M Sajid Hussain et al.   CLINICAL GENETICS

Centrosome asymmetry and inheritance during animal development

(2012) Laurence Pelletier et al.   CURRENT OPINION IN CELL BIOLOGY

Astrocytes and disease: a neurodevelopmental perspective

(2012) A. V. Molofsky et al.   GENES & DEVELOPMENT

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

(2012) M. A. Bogoyevitch et al.   JOURNAL OF CELL SCIENCE

A novel WDR62 mutation causes primary microcephaly in a Pakistani family

(2012) Mazhar Mustafa Memon et al.   MOLECULAR BIOLOGY REPORTS

Genetic causes of microcephaly and lessons for neuronal development

(2012) Edward C. Gilmore et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Whole-exome sequencing identifies compound heterozygous mutations in WDR62 in siblings with recurrent polymicrogyria

(2011) David R. Murdock et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Docking interactions of the JNK scaffold protein WDR62

(2011) Ksenya Cohen-Katsenelson et al.   BIOCHEMICAL JOURNAL

Mutations in WDR62 gene in Pakistani families with autosomal recessive primary microcephaly

(2011) Rizwana Kousar et al.   BMC Neurology

Mutations in WDR62, encoding a centrosomal and nuclear protein, in Indian primary microcephaly families with cortical malformations

(2011) V Bhat et al.   CLINICAL GENETICS

What disorders of cortical development tell us about the cortex: one plus one does not always make two

(2011) M Chiara Manzini et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate

(2011) Nina Westerlund et al.   NATURE NEUROSCIENCE

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

Cnn Dynamics Drive Centrosome Size Asymmetry to Ensure Daughter Centriole Retention in Drosophila Neuroblasts

(2010) Paul T. Conduit et al.   CURRENT BIOLOGY

Neural stem cells: the need for a proper orientation

(2010) Bart Lesage et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cortical progenitor expansion, self-renewal and neurogenesis—a polarized perspective

(2010) Simone A Fietz et al.   CURRENT OPINION IN NEUROBIOLOGY

Aurora A contributes to p150gluedphosphorylation and function during mitosis

(2010) Pierre Romé et al.   JOURNAL OF CELL BIOLOGY

CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response

(2010) Alexis R. Barr et al.   JOURNAL OF CELL BIOLOGY

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

(2010) Kaya Bilgüvar et al.   NATURE

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

(2010) Timothy W Yu et al.   NATURE GENETICS

WDR62 is associated with the spindle pole and is mutated in human microcephaly

(2010) Adeline K Nicholas et al.   NATURE GENETICS

The Apical Complex Couples Cell Fate and Cell Survival to Cerebral Cortical Development

(2010) Seonhee Kim et al.   NEURON

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline

(2010) J. N. Pulvers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WD40 proteins propel cellular networks

(2010) Christian U. Stirnimann et al.   TRENDS IN BIOCHEMICAL SCIENCES

BRIT1/MCPH1 Is Essential for Mitotic and Meiotic Recombination DNA Repair and Maintaining Genomic Stability in Mice

(2010) Yulong Liang et al.   PLoS Genetics

c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges

(2009) Marie A. Bogoyevitch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Novel c-Jun N-terminal Kinase (JNK)-binding Protein WDR62 Is Recruited to Stress Granules and Mediates a Nonclassical JNK Activation

(2009) Tanya Wasserman et al.   MOLECULAR BIOLOGY OF THE CELL

Asymmetric centrosome inheritance maintains neural progenitors in the neocortex

(2009) Xiaoqun Wang et al.   NATURE

Mechanisms of Asymmetric Stem Cell Division

(2008) Juergen A. Knoblich   CELL

Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts

(2008) Karsten H. Siller et al.   DEVELOPMENTAL BIOLOGY