Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme

Engineering adeno-associated virus vectors for gene therapy

(2020) Chengwen Li et al.   NATURE REVIEWS GENETICS

Capsid-specific removal of circulating antibodies to adeno-associated virus vectors

(2020) Berangere Bertin et al.   Scientific Reports

Successful Transduction with AAV Vectors after Selective Depletion of Anti-AAV Antibodies by Immunoadsorption

(2020) Alejandro Orlowski et al.   Molecular Therapy-Methods & Clinical Development

IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies

(2020) Christian Leborgne et al.   NATURE MEDICINE

Human Immune Responses to Adeno-Associated Virus (AAV) Vectors

(2020) Giuseppe Ronzitti et al.   Frontiers in Immunology

Adeno-associated virus vector as a platform for gene therapy delivery

(2019) Dan Wang et al.   NATURE REVIEWS DRUG DISCOVERY

From Clinical Trials to Clinical Practice: Practical Considerations for Gene Replacement Therapy in SMA Type 1

(2019) Samiah A. Al-Zaidy et al.   PEDIATRIC NEUROLOGY

Future developments in kidney transplantation

(2019) Ondrej Viklicky et al.   Current Opinion in Organ Transplantation

Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex–mediated immune responses

(2019) L. J. Blumberg et al.   Science Advances

Safety, immunogenicity, pharmacokinetics, and efficacy of degradation of anti-HLA antibodies by IdeS (imlifidase) in chronic kidney disease patients

(2018) Tomas Lorant et al.   AMERICAN JOURNAL OF TRANSPLANTATION

IdeS (Imlifidase)

(2018) Bonnie E. Lonze et al.   ANNALS OF SURGERY

Prevalence and long-term monitoring of humoral immunity against adeno-associated virus in Duchenne Muscular Dystrophy patients

(2018) Christian Leborgne et al.   CELLULAR IMMUNOLOGY

Enabling redosing of AAV by immune management in Pompe disease: Preclinical to clinical studies

(2018) Manuela Corti et al.   MOLECULAR GENETICS AND METABOLISM

Influence of Pre-existing Anti-capsid Neutralizing and Binding Antibodies on AAV Vector Transduction

(2018) Zachary Fitzpatrick et al.   Molecular Therapy-Methods & Clinical Development

Exposure to wild-type AAV drives distinct capsid immunity profiles in humans

(2018) Klaudia Kuranda et al.   JOURNAL OF CLINICAL INVESTIGATION

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration

(2018) Amine Meliani et al.   Nature Communications

IgG-degrading enzyme of Streptococcus pyogenes (IdeS) prevents disease progression and facilitates improvement in a rabbit model of Guillain-Barré syndrome

(2017) Yuzhong Wang et al.   EXPERIMENTAL NEUROLOGY

IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation

(2017) Stanley C. Jordan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion

(2017) Longping Victor Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study

(2017) Peter Kiessling et al.   Science Translational Medicine

Overcoming the Host Immune Response to Adeno-Associated Virus Gene Delivery Vectors: The Race Between Clearance, Tolerance, Neutralization, and Escape

(2017) Federico Mingozzi et al.   Annual Review of Virology

In vivo enzymatic modulation of IgG antibodies prevents immune complex-dependent skin injury

(2016) Sidonia Mihai et al.   EXPERIMENTAL DERMATOLOGY

Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer

(2016) Chengwen Li et al.   MOLECULAR THERAPY

Strategies to circumvent humoral immunity to adeno-associated viral vectors

(2015) Longping V Tse et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Prediction of adeno-associated virus neutralizing antibody activity for clinical application

(2015) M Wang et al.   GENE THERAPY

Streptococcal IdeS: therapeutic potential for Guillain–Barré syndrome

(2015) Ryo Takahashi et al.   Scientific Reports

Evaluation of Readministration of a Recombinant Adeno-Associated Virus Vector Expressing Acid Alpha-Glucosidase in Pompe Disease: Preclinical to Clinical Planning

(2015) Manuela Corti et al.   Human Gene Therapy Clinical Development

Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS – A Novel Therapeutic Opportunity

(2015) Lena Winstedt et al.   PLoS One

A Structurally Distinct Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union

(2014) R. K. Grover et al.   SCIENCE

B-cell depletion is protective against anti-AAV capsid immune response: a human subject case study

(2014) M Corti et al.   Molecular Therapy-Methods & Clinical Development

Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys

(2013) F. Mingozzi et al.   Science Translational Medicine

Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia

(2011) C Li et al.   GENE THERAPY

Impact of Pre-Existing Immunity on Gene Transfer to Nonhuman Primate Liver with Adeno-Associated Virus 8 Vectors

(2011) Lili Wang et al.   HUMAN GENE THERAPY

Humoral Immunity to AAV-6, 8, and 9 in Normal and Dystrophic Dogs

(2011) Jin-Hong Shin et al.   HUMAN GENE THERAPY

A 10 Patient Case Report on the Impact of Plasmapheresis Upon Neutralizing Factors Against Adeno-associated Virus (AAV) Types 1, 2, 6, and 8

(2011) Virginie Monteilhet et al.   MOLECULAR THERAPY

Neutralizing Antibodies Against AAV Serotypes 1, 2, 6, and 9 in Sera of Commonly Used Animal Models

(2011) Kleopatra Rapti et al.   MOLECULAR THERAPY

Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors

(2010) Sylvie Boutin et al.   HUMAN GENE THERAPY

Two novel IgG endopeptidases ofStreptococcus equi

(2009) Greta Hulting et al.   FEMS MICROBIOLOGY LETTERS

Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses

(2009) Roberto Calcedo et al.   JOURNAL OF INFECTIOUS DISEASES

IdeS: A Bacterial Proteolytic Enzyme with Therapeutic Potential

(2008) Björn P. Johansson et al.   PLoS One

Prolonged Susceptibility to Antibody-mediated Neutralization for Adeno-associated Vectors Targeted to the Liver

(2007) Samuel L Murphy et al.   MOLECULAR THERAPY