Bacteriophage endolysins as a potential weapon to combat Clostridioides difficile infection

Trends in U.S. Burden of Clostridioides difficile Infection and Outcomes

(2020) Alice Y. Guh et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Clostridioides difficile Infection in Mice

(2019) Zhong Peng et al.   Frontiers in Microbiology

Cell Wall Hydrolases in Bacteria: Insight on the Diversity of Cell Wall Amidases, Glycosidases and Peptidases Toward Peptidoglycan

(2019) Aurore Vermassen et al.   Frontiers in Microbiology

Endolysins as emerging alternative therapeutic agent to counter drug resistant infections.

(2019) Vijay Singh Gondil et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Synthetic biology of modular endolysins

(2018) Hans Gerstmans et al.   BIOTECHNOLOGY ADVANCES

Development of Phage Lysins as Novel Therapeutics: A Historical Perspective

(2018) Vincent Fischetti   Viruses-Basel

Are Phage Lytic Proteins the Secret Weapon To Kill Staphylococcus aureus?

(2018) Diana Gutiérrez et al.   mBio

Clostridium difficile – From Colonization to Infection

(2018) Holger Schäffler et al.   Frontiers in Microbiology

Clostridium difficile infection: Evolution, phylogeny and molecular epidemiology

(2017) Briony Elliott et al.   INFECTION GENETICS AND EVOLUTION

A Clostridioides difficile bacteriophage genome encodes functional binary toxin-associated genes

(2017) Thomas Riedel et al.   JOURNAL OF BIOTECHNOLOGY

Hot topic: Antilisterial activity by endolysin PlyP100 in fresh cheese

(2017) Maxwell L. Van Tassell et al.   JOURNAL OF DAIRY SCIENCE

Targeted anti-staphylococcal therapy with endolysins in atopic dermatitis and the effect on steroid use, disease severity and the microbiome: study protocol for a randomized controlled trial (MAAS trial)

(2017) Joan Totté et al.   Trials

A Novel Chimeric Endolysin with Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus

(2017) Hamed Haddad Kashani et al.   Frontiers in Cellular and Infection Microbiology

Phages in the Human Body

(2017) Ferran Navarro et al.   Frontiers in Microbiology

The emergence of Clostridium difficile infection in Asia: A systematic review and meta-analysis of incidence and impact

(2017) Nienke Z. Borren et al.   PLoS One

From endolysins to Artilysin(R)s: novel enzyme-based approaches to kill drug-resistant bacteria

(2016) H. Gerstmans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Newly identified bacteriolytic enzymes that target a wide range of clinical isolates ofClostridium difficile

(2016) Krunal K. Mehta et al.   BIOTECHNOLOGY AND BIOENGINEERING

Comparative genomic analysis of toxin-negative strains of Clostridium difficile from humans and animals with symptoms of gastrointestinal disease

(2016) Piklu Roy Chowdhury et al.   BMC MICROBIOLOGY

Creative lysins: Listeria and the engineering of antimicrobial enzymes

(2016) Maxwell L Van Tassell et al.   CURRENT OPINION IN BIOTECHNOLOGY

Alternatives to antibiotics—a pipeline portfolio review

(2016) Lloyd Czaplewski et al.   LANCET INFECTIOUS DISEASES

Breakthroughs in the treatment and prevention of Clostridium difficile infection

(2016) Larry K. Kociolek et al.   Nature Reviews Gastroenterology & Hepatology

Two Novel Myoviruses from the North of Iraq Reveal Insights into Clostridium difficile Phage Diversity and Biology

(2016) Srwa Rashid et al.   Viruses-Basel

A bacteriophage endolysin that eliminates intracellular streptococci

(2016) Yang Shen et al.   eLife

Structural and Enzymatic Characterization of ABgp46, a Novel Phage Endolysin with Broad Anti-Gram-Negative Bacterial Activity

(2016) Hugo Oliveira et al.   Frontiers in Microbiology

Using a Novel Lysin To Help Control Clostridium difficile Infections

(2015) Qiong Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacteriophage Combinations Significantly Reduce Clostridium difficile GrowthIn Vitroand ProliferationIn Vivo

(2015) Janet Y. Nale et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergistic streptococcal phage λSA2 and B30 endolysins kill streptococci in cow milk and in a mouse model of mastitis

(2015) Mathias Schmelcher et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Phage lytic proteins: biotechnological applications beyond clinical antimicrobials

(2015) Lorena Rodríguez-Rubio et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Breaking barriers: expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria

(2015) Yves Briers et al.   Future Microbiology

The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection

(2015) Xingmin Sun et al.   MOLECULAR IMMUNOLOGY

Clostridium difficile Infection

(2015) Daniel A. Leffler et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus”

(2015) Katherine Hargreaves et al.   Viruses-Basel

Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile

(2015) Pierre Boudry et al.   mBio

A chimeolysin with extended-spectrum streptococcal host range found by an induced lysis-based rapid screening method

(2015) Hang Yang et al.   Scientific Reports

Preclinical Safety Evaluation of Intravenously Administered SAL200 Containing the Recombinant Phage Endolysin SAL-1 as a Pharmaceutical Ingredient

(2014) Soo Youn Jun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of Temperate Phages Infecting Clostridium difficile Isolates of Human and Animal Origins

(2014) Ognjen Sekulovic et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

New Role for Human α-Defensin 5 in the Fight against Hypervirulent Clostridium difficile Strains

(2014) Lucinda Furci et al.   INFECTION AND IMMUNITY

Phage lysis: Three steps, three choices, one outcome

(2014) Ryland Young   JOURNAL OF MICROBIOLOGY

Application ofLactobacillus johnsoniiexpressing phage endolysin for control ofClostridium perfringens

(2014) T. Gervasi et al.   LETTERS IN APPLIED MICROBIOLOGY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

What Does the Talking?: Quorum Sensing Signalling Genes Discovered in a Bacteriophage Genome

(2014) Katherine R. Hargreaves et al.   PLoS One

Engineered Endolysin-Based "Artilysins" To Combat Multidrug-Resistant Gram-Negative Pathogens

(2014) Y. Briers et al.   mBio

Abundant and Diverse Clustered Regularly Interspaced Short Palindromic Repeat Spacers in Clostridium difficile Strains and Prophages Target Multiple Phage Types within This Pathogen

(2014) K. R. Hargreaves et al.   mBio

Clostridium difficile phages: still difficult?

(2014) Katherine R. Hargreaves et al.   Frontiers in Microbiology

Guidelines for Diagnosis, Treatment and Prevention of Clostridium difficile Infections

(2013) Christina M Surawicz et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus

(2013) Daniel B. Gilmer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Narrow-Host-Range Bacteriophages That Infect Rhizobium etli Associate with Distinct Genomic Types

(2013) Rosa Isela Santamaría et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Expression and delivery of an endolysin to combat Clostridium perfringens

(2013) Teresa Gervasi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Novel avenues for Clostridium difficile infection drug discovery

(2013) Mario Zucca et al.   Expert Opinion on Drug Discovery

Impact of cleaning and other interventions on the reduction of hospital-acquired Clostridium difficile infections in two hospitals in England assessed using a breakpoint model

(2013) G.J. Hughes et al.   JOURNAL OF HOSPITAL INFECTION

Gut solutions to a gut problem: bacteriocins, probiotics and bacteriophage for control of Clostridium difficile infection

(2013) M. C. Rea et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Evidence ofIn VivoProphage Induction during Clostridium difficile Infection

(2012) Mathieu Meessen-Pinard et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Photosensitizer and vancomycin-conjugated novel multifunctional magnetic particles as photoinactivation agents for selective killing of pathogenic bacteria

(2012) Kyong-Hoon Choi et al.   CHEMICAL COMMUNICATIONS

Consequences of Clostridium difficile infection: understanding the healthcare burden

(2012) E. Bouza   CLINICAL MICROBIOLOGY AND INFECTION

Bacteriophage endolysins as novel antimicrobials

(2012) Mathias Schmelcher et al.   Future Microbiology

Multiple Factors Modulate Biofilm Formation by the Anaerobic Pathogen Clostridium difficile

(2012) T. Thapa et al.   JOURNAL OF BACTERIOLOGY

The Spanin Complex Is Essential for Lambda Lysis

(2012) J. Berry et al.   JOURNAL OF BACTERIOLOGY

Mycobacteriophage Endolysins: Diverse and Modular Enzymes with Multiple Catalytic Activities

(2012) Kimberly M. Payne et al.   PLoS One

Bacteriophage endolysins as a response to emerging foodborne pathogens

(2012) Hugo Oliveira et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

In VitroDestruction of Streptococcus pneumoniae Biofilms with Bacterial and Phage Peptidoglycan Hydrolases

(2011) Mirian Domenech et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The influence of external factors on bacteriophages—review

(2011) E. Jończyk et al.   FOLIA MICROBIOLOGICA

Use of bacteriophage endolysin EL188 and outer membrane permeabilizers against Pseudomonas aeruginosa

(2011) Y. Briers et al.   JOURNAL OF APPLIED MICROBIOLOGY

Prophage-Stimulated Toxin Production in Clostridium difficile NAP1/027 Lysogens

(2011) O. Sekulovic et al.   JOURNAL OF BACTERIOLOGY

Structure-Based Modification of a Clostridium difficile-Targeting Endolysin Affects Activity and Host Range

(2011) M. J. Mayer et al.   JOURNAL OF BACTERIOLOGY

Clostridium difficileHas an Original Peptidoglycan Structure with a High Level ofN-Acetylglucosamine Deacetylation and Mainly 3-3 Cross-links

(2011) Johann Peltier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergism between a Novel Chimeric Lysin and Oxacillin Protects against Infection by Methicillin-Resistant Staphylococcus aureus

(2010) A. Daniel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel Chimeric Lysin Shows Superiority to Mupirocin for Skin Decolonization of Methicillin-Resistant and -SensitiveStaphylococcus aureusStrains

(2010) Mina Pastagia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Food applications of bacterial cell wall hydrolases

(2010) Lien Callewaert et al.   CURRENT OPINION IN BIOTECHNOLOGY

Genome analysis of the Clostridium difficile phage ΦCD6356, a temperate phage of the Siphoviridae family

(2010) Marianne Horgan et al.   GENE

Bacteriophage endolysins: A novel anti-infective to control Gram-positive pathogens

(2010) Vincent A. Fischetti   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The lambda spanin components Rz and Rz1 undergo tertiary and quaternary rearrangements upon complex formation

(2010) Joel Berry et al.   PROTEIN SCIENCE

The high-affinity peptidoglycan binding domain of Pseudomonas phage endolysin KZ144

(2009) Yves Briers et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia*

(2009) Martin Witzenrath et al.   CRITICAL CARE MEDICINE

Vancomycin-Modified Nanoparticles for Efficient Targeting and Preconcentration of Gram-Positive and Gram-Negative Bacteria

(2008) Arnold J. Kell et al.   ACS Nano

Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery

(2008) Monty Liong et al.   ACS Nano

Molecular Characterization of a Clostridium difficile Bacteriophage and Its Cloned Biologically Active Endolysin

(2008) M. J. Mayer et al.   JOURNAL OF BACTERIOLOGY

Identification and functional analysis of the Rz/Rz1-like accessory lysis genes in the membrane-containing bacteriophage PRD1

(2008) Mart Krupovič et al.   MOLECULAR MICROBIOLOGY