Article
Polymer Science
Ayesha Siddiqua, Nazar Muhammad Ranjha, Sadia Rehman, Hina Shoukat, Nasreen Ramzan, Humaira Sultana
Summary: By manufacturing a pH-sensitive and biocompatible interpenetrating polymer network device, the targeting and absorption enhancement of BCS III drugs in the colon can be achieved. The porosity and gel fraction of the hydrogel were related to the content of pectin and acrylamide, and the drug release mechanism was mainly Fickian diffusion.
Article
Pharmacology & Pharmacy
Cassiele T. Cesco, Artur J. M. Valente, Alexandre T. Paulino
Summary: Chitosan/DNA blend hydrogel and chitosan/pectin blend hydrogel were synthesized for releasing methylene blue, and characterized by various techniques. The study revealed that the methylene blue loading had different impacts on the hydrogels, with higher release rates observed in simulated gastric fluid. The release kinetics of methylene blue in the hydrogels followed a pseudo-second-order mechanism.
Review
Biochemistry & Molecular Biology
Minke Yang, Shaojie Zhao, Chengying Zhao, Jiefen Cui, Yanqi Wang, Xiang Fang, Jinkai Zheng
Summary: In this study, protein-reinforced pectin hydrogel beads were developed to overcome the limitations of porous networks and poor mechanical properties. HBPEC-CAS showed a compact network structure and high encapsulation efficiency of EGC, with the ability to delay its release in an aqueous environment and ensure sufficient release in a simulated gastrointestinal environment. Furthermore, EGC was chemically stabilized in HBPEC-CAS through the inhibition of its epimerization, oxidation, dimerization, and trimerization. These findings offer valuable insights for the tea-based food and beverage industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Chenmin Zheng, Wanping Huang, Yuping Zou, Wensi Huang, Peng Fei, Guoguang Zhang
Summary: In this study, pectin was modified with phenylalanine using an ultra-low temperature enzymatic method to enhance its gel properties. The grafting ratio of phenylalanine amidated pectin was investigated under different reaction conditions. The results showed that phenylalanine amidated pectin can form hydrogel with a certain strength under acidic conditions, and it exhibits sustained and complete drug release, making it a promising sustained-release drug carrier.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Ha N. Giang, Anh T. K. Le, Tuan N. A. Huynh, Thanh Khoa Phung, Wataru Sakai
Summary: This study cross-linked hydroxypropyl methylcellulose using citric acid and found that the addition of polyethylene glycol significantly improved the gel fraction of the hydrogel.
Article
Chemistry, Applied
Chenmin Zheng, Yuping Zou, Yufan Huang, Bihua Shen, Peng Fei, Guoguang Zhang
Summary: In this study, amidated pectin with ultra-high viscosity and low gelation restriction was prepared by enzymatic method at ultra-low temperature. The V-PE, with the highest amino acid grafting ratio, exhibited the highest solution viscosity and gel hardness, and had better thermal stability.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Daniele M. Catori, Elizangela H. Fragal, Igor Messias, Francielle P. Garcia, Celso Nakamura, Adley F. Rubira
Summary: This study focused on evaluating the effects of cellulose nanocrystals on pectin hydrogels and the properties of hydroxyapatite obtained through different methods. The results showed that hydrogels with 5% cellulose nanocrystals exhibited better mineralization of hydroxyapatite in the biomimetic method. Overall, hydrogels obtained through biomimetic method showed slightly higher biocompatibility compared to hybrid hydrogels obtained from chemical precipitation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Analytical
Pinar Ilgin
Summary: In this study, a pectin/poly(MA-co-AMPS) hydrogel was successfully synthesized and its swelling behavior was investigated. The chemical structure of the hydrogel was confirmed using FT-IR spectroscopy, and surface morphology assessment was performed using SEM. The hydrogel exhibited excellent adsorption capacity for cationic dyes, with adsorption kinetics following a pseudo-second-order model and adsorption isotherms described by the Langmuir model.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Wancheng Chen, Sijie Yuan, Jie Shen, Yongsheng Chen, Yang Xiao
Summary: The composite hydrogel CH-P 40% demonstrated a dense network structure, retained various chemical bonds, cellulose crystal structures, and showed favorable thermal stability. It also exhibited increased cell proliferation rates and no pathological lesions in mouse organs, indicating good biocompatibility. Additionally, the hydrogel-treated liver wounds showed less bleeding within 3 minutes, highlighting its potential as a rapid hemostatic biomedical material.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Environmental
Wilson Bokorny Fernandes Filho, Sedami Tozoun Romain Agassin, Karine Priscila Naidek, Alexandre Tadeu Paulino
Summary: Hydrogels modified with montmorillonite were synthesized and used for the removal of dyes and herbicides from water. The structure and adsorption properties of the hydrogels were studied using various analytical methods, demonstrating their excellent adsorption performance and reusability.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Bihua Shen, Zhengli Guo, Bingqing Huang, Guoguang Zhang, Peng Fei, Shirong Hu
Summary: In this study, hydrogel adsorbents were prepared using pectin with different esterification degrees, and the effect of esterification degree on the structure and adsorption performance of the hydrogels was studied. The results showed that hydrogels prepared from pectin with low esterification degree had stronger adsorption capacity, and the adsorption behavior was analyzed through kinetics and thermodynamics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Polymer Science
Nurul Saadah Said, Ibukunoluwa Fola Olawuyi, Won Young Lee
Summary: Pectin hydrogels have gained attention in the food industry for their versatility and promising properties. This review provides an overview of the gelling mechanisms and classification of pectin hydrogels, as well as the preparation processes and crosslinking methods. It explores the diverse applications of pectin hydrogels in the food industry and emphasizes the importance of understanding the crosslinking mechanisms for optimizing their potential.
Article
Polymer Science
Regina R. Vildanova, Svetlana F. Petrova, Sergey V. Kolesov, Vitaliy V. Khutoryanskiy
Summary: Preparation of stable hydrogels using charge-complementary polyelectrolyte chains offers practical advantages over the use of organic crosslinking agents. This study utilizes natural polyelectrolytes-chitosan and pectin-with their biocompatibility and biodegradability. Different molecular weights of pectin are used to prepare hydrogels with varying rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels can release the cytostatic drug cisplatin over an extended period, potentially improving the effectiveness of cancer treatment.
Article
Polymer Science
Nam-Gyun Kim, Pathum Chandika, Se-Chang Kim, Dong-Hoon Won, Won Sun Park, Il-Whan Choi, Sang Gil Lee, Young-Mog Kim, Won-Kyo Jung
Summary: The use of self-healing hydrogels in wound dressings can protect them from mechanical damage and extend their lifespan. In this study, a hydrogel with rapid self-healing properties and high antibacterial activity was fabricated by testing different mixing ratios of hyaluronic acid (HA) and pectin (PT) using Fe3+ cross-linking. The optimal Fe3+-cross-linked HA/PT hydrogel showed potential for wound-healing applications due to its self-healing properties and antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa.
Article
Biochemistry & Molecular Biology
Liping Yin, Wenhao Duan, Yanai Chen, Danyang Chen, Yong Wang, Shuai Guo, Jianglei Qin
Summary: Serious side effects of chemotherapy drugs can be limited by targeted drug delivery using biodegradable hydrogel. In this study, a hydrogel made from pectin hydrazide (pec-H) and oxidized carboxymethyl cellulose (DCMC) was developed for localized Silibinin delivery in lung adenocarcinoma treatment. The hydrogel showed blood and cell compatibility, enzyme degradability, and pH-sensitive sustained drug release. In vivo experiments showed that the hydrogel-loaded Silibinin significantly enhanced anti-tumor efficiency and reduced toxicity. The pec-H/DCMC hydrogel loaded with Silibinin has promising prospects for inhibiting lung tumor growth in clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Nadiah Zafar, Muhammad Akhlaq, Asif Mahmood, Hira Ijaz, Rai Muhammad Sarfraz, Zahid Hussain, Zainab Masood
Summary: This study reported the use of HPMC/AA hydrogel loaded with AZA for the treatment of Crohn's disease, and demonstrated the potential application of HPMC/AA hydrogel for colon targeting of AZA.
Article
Polymer Science
Ayesha Mahmood, Asif Mahmood, Rai Muhammad Sarfraz, Hira Ijaz, Nadiah Zafar, Muhammad Umar Ashraf
Summary: A pH-responsive pectin-co-poly(MAA) hydrogel containing diloxanide furoate was developed for the treatment of amebiasis. The hydrogel exhibited efficient drug loading, swelling behavior, and drug release kinetics. The optimized hydrogel showed pH-responsive swelling and drug release in an alkaline environment, indicating its potential for colon delivery.
Article
Pharmacology & Pharmacy
Narimane Lammari, Mehdi Louaer, Ouahida Louaer, Chawki Bensouici, Ahmed Zermane, Abdelhamid Elaissari, Abdeslam Hassen Meniai
Summary: This study focuses on the encapsulation of Sesamum indicum L. seed oil in new nanoparticles and evaluates its antioxidant and enzymatic inhibition effects. The results show that the formulation has high antidiabetic activity and moderate antiurease and anti-Alzheimer activities.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Editorial Material
Engineering, Chemical
Noureddine Lebaz, Alain Line, Nida Sheibat-Othman, Jerome Morchain
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)
Review
Chemistry, Applied
Eslam Elkalla, Sumera Khizar, Mohamad Tarhini, Noureddine Lebaz, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Abdelhamid Elaissari
Summary: Encapsulation is a process of wrapping one substance inside another at micro and nano scale to protect the active ingredients. Different types of capsules made of natural and synthetic polymers can effectively encapsulate various active substances and release them through different mechanisms. This technology is important in several industries such as food, pharmaceutical, cosmetics, agriculture, and textile. The review focuses on the most important methods of manufacturing micro/nanocapsules and their applications in our daily lives.
JOURNAL OF MICROENCAPSULATION
(2023)
Article
Pharmacology & Pharmacy
Nadiah Zafar, Asif Mahmood, Sehar Ilyas, Hira Ijaz, Rai Muhammad Sarfraz, Wael A. Mahdi, Mounir M. Salem-Bekhit, Mohamed A. Ibrahim, Yacine Benguerba, Barbara Ernst
Summary: This study aimed to create a controlled delivery system for Tapentadol Hydrochloride by developing interpenetrating networks (IPNs) of Natrosol-Pectin copolymerized with Acrylic Acid and Methylene bisacrylamide, and found that the developed IPNs were an excellent system for the controlled delivery of Tapentadol Hydrochloride.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Zouhair Ait-Touchente, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Noureddine Lebaz, Hatem Fessi, Abdelhamid Elaissari
Summary: Microemulsions are novel drug delivery systems with desirable characteristics for delivering hydrophilic and hydrophobic drugs. This comprehensive review explores various aspects of microemulsions, including formulation, characterization, and applications, with a focus on their potential for cutaneous drug delivery. The review highlights the promise of microemulsions in overcoming bioavailability concerns and enabling sustained drug delivery, emphasizing the importance of understanding their formulation and characterization for optimizing effectiveness and safety. Additionally, the review delves into different types of microemulsions, their composition, and factors affecting their stability, while discussing their potential as drug delivery systems for skin applications.
Review
Pharmacology & Pharmacy
Noor Alrushaid, Firdos Alam Khan, Ebtesam Abdullah Al-Suhaimi, Abdelhamid Elaissari
Summary: Nanoparticles play a crucial role in cancer diagnosis and treatment by improving drug delivery to tumors and reducing side effects. Various types of nanoparticles, including metallic, magnetic, polymeric, metal oxide, quantum dots, graphene, fullerene, liposomes, carbon nanotubes, and dendrimers, have great potential in cancer treatment. Additionally, nanoparticles have shown intrinsic anticancer activity and can facilitate controlled drug release.
Article
Chemistry, Physical
Noureddine Lebaz, Kristy Touma, Nida Sheibat-Othman
Summary: A novel method for preparing water-in-oil-in-water double emulsions using a two-step process with high shear device and static mixers is proposed and evaluated. The method showed efficient formation of monomodal droplet size distributions and high encapsulation efficiency, despite the shear thinning behavior of the inner emulsions. The range of droplet size variation in the double emulsion could be controlled while maintaining a residence time of less than a second, making this process a promising alternative to traditional batch processes.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Review
Chemistry, Inorganic & Nuclear
Hira Ijaz, Asif Mahmood, Mohamed M. Abdel-Daim, Rai Muhammad Sarfraz, Muhammad Zaman, Nadiah Zafar, Sultan Alshehery, Mounir M. Salem-Bekhit, Mohammed Azam Ali, Lienda Bashier Eltayeb, Yacine Benguerba
Summary: This comprehensive review article discusses the unique chemical and physical properties of carbon nanotubes (CNTs) and their biomedical applications. The focus is on the research findings, functionalization, and applications of CNTs from different researchers. In-vitro and in-vivo drug delivery using doxorubicin for anti-cancer treatment has been extensively investigated. In addition, single-wall carbon nanotubes (SWCNTs) have shown potential as optical contrast agents for cell imaging due to their Raman and photoluminescence properties. In vitro and in vivo toxicity studies have demonstrated the biocompatibility and safety of hydrophilic serum-stable CNTs. The biodistribution of CNTs is influenced by functionalization, with small particles accumulating in the reticuloendothelial system (RES) of vital organs such as the heart, kidney, and spleen. The significant potential of CNTs in various biomedical applications is highlighted in this review.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Aysha Aslam, Muhammad Umer Ashraf, Kashif Barkat, Asif Mahmood, Rai Muhammad Sarfraz, Rania T. Malatani, Heba A. Gad
Summary: The present study successfully utilized green synthesis to fabricate pH-responsive quince/pectin cross-linked hydrogel sponges for the conveyance of domperidone. The hydrogel sponges displayed good swelling and drug release properties, and showed no toxicity or biocompatibility in toxicological studies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Crystallography
Cristian Camilo Ruiz Vasquez, Noureddine Lebaz, Isabelle Ramiere, Sophie Lalleman, Denis Mangin, Murielle Bertrand
Summary: A numerical methodology is developed to solve the steady state Population Balance Equation (PBE) in this work. Three crystallisation mechanisms, including nucleation, size-independent growth and size-dependent loose agglomeration, are included. The method is based on the discretisation of crystal size as a distributed variable and can accurately predict the mean particle size under experimental uncertainty in a reasonable computation time and number of iterations.
JOURNAL OF CRYSTAL GROWTH
(2023)
Article
Pharmacology & Pharmacy
Fatima Noor, Asif Mahmood, Nadiah Zafar, Rai Muhammad Sarfraz, Umaira Rehman, Hira Ijaz, Zahid Hussain, Inas A. Ahmed, Mohammad Tarique Imam, Waleed Al Abdulmonem, Krishna Kumar Yadav, Yacine Benguerba
Summary: This study successfully synthesized an intelligent pH-responsive hydrogel for the controlled release of perindopril erbumine. The hydrogel showed higher swelling and drug release at alkaline pH, indicating a sustained release pattern. Additionally, oral toxicity studies demonstrated the non-toxicity of the synthesized system.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Iqra Ahmed, Asif Mahmood, Omer Salman Qureshi, Rai Muhammad Sarfraz, Hira Ijaz, Muhammad Zaman, Muhammad Rouf Akram, Sufyan Usmani, Zulcalf, Maria Malook
Summary: A novel hydrogel composed of crosslinked tamarind gum and ss-cyclodextrin graft-poly(methacrylic acid) was developed for colon targeting. The hydrogel demonstrated significant swelling and drug release at pH 7.4 compared to pH 1.2. The developed hydrogel showed promising potential as a pH-responsive carrier for colon targeting.
Article
Chemistry, Multidisciplinary
Anis Madaci, Patcharapan Suwannin, Guy Raffin, Marie Hangouet, Marie Martin, Hana Ferkous, Abderrazak Bouzid, Joan Bausells, Abdelhamid Elaissari, Abdelhamid Errachid, Nicole Jaffrezic-Renault
Summary: In this paper, a microconductometric sensor based on a chitosan composite including alcohol dehydrogenase, its cofactor, and gold nanoparticles was designed and calibrated. The presence of gold nanoparticles significantly improved the response time, sensitivity, selectivity, and reproducibility of the ethanol sensor. Compared to without gold nanoparticles, the response time was reduced to 10 s, sensitivity was 11.3 times higher, selectivity factor versus methanol was three times higher, and relative standard deviation was significantly lower.
