Article
Cell Biology
Yu-kun Zheng, Zhong-shi Zhou, Guang-zhong Wang, Ji-yuan Tu, Huan-bo Cheng, Shang-zhi Ma, Chang Ke, Yan Wang, Qi-pan Jian, Yu-hang Shu, Xiao-wei Wu
Summary: This study found that inhibiting miR-122-5p can activate p53 and hinder the progression of the MVA pathway in non-small cell lung cancer (NSCLC). This leads to a decrease in cell proliferation and migration, and an increase in apoptosis. miR-122-5p interacts with p53 and is negatively correlated with its expression. Thus, miR-122-5p regulates NSCLC by targeting p53, offering potential molecular targets for targeted drug development.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Pranavi Garlapati, Jinjie Ling, Paul J. Chiao, Jie Fu
Summary: Circular RNAs play a significant role in cancer as diagnostic and prognostic biomarkers and therapeutic targets. They regulate cell signaling pathways by modulating particular gene expressions in different cancers.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Matin Alavi, Tahereh Farkhondeh, Michael Aschner, Saeed Samarghandian
Summary: Cancer poses a major health issue with current therapies being generally ineffective, while resveratrol shows potential for cancer treatment but requires further research due to controversies over its mechanisms of action.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Klaudia Klicka, Tomasz M. Grzywa, Alicja Klinke, Aleksandra Mielniczuk, Jaroslaw Wejman, Joanna Ostrowska, Agata Gondek, Pawel K. Wlodarski
Summary: This study aimed to assess the expression levels of 16 miRNAs in endometrial cancer and found aberrant expression profiles in some miRNAs. This research is important for understanding the epigenetic mechanisms and potential development of endometrial cancer.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Huibin Zhang, Jinglin Wang, Fan Xie, Yangguang Liu, Mengyao Qiu, Zheng Han, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhang
Summary: This study investigated the effects of resveratrol (RSV) on the apoptosis of porcine ovarian granulosa cells (POGCs) through miRNA regulation. The results showed that RSV promoted POGCs apoptosis by regulating the expression of miRNAs, and also provided insights into the role of miRNAs combined with RSV in ovarian granulosa cell development in pigs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Yesim Verel-Yilmaz, Juan Pablo Fernandez, Agnes Schaefer, Sheila Nevermann, Lena Cook, Norman Gercke, Frederik Helmprobst, Christian Jaworek, Elke Pogge von Strandmann, Axel Pagenstecher, Detlef K. Bartsch, Joerg W. Bartsch, Emily P. Slater
Summary: The study aimed to determine whether ADAM8-positive extracellular vesicles (EVs) and cargo microRNAs could distinguish PDAC or its precursor lesions from healthy controls. FACS analysis and EV cargo analysis of miRNAs revealed a potential diagnostic biomarker set to discriminate PDAC and precursor lesions from healthy controls.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Jennifer Sally Samson, Venkatachalam Deepa Parvathi
Summary: Lung cancer is the second most common cancer worldwide and the leading cause of cancer-related deaths. Non-small-cell lung carcinoma (NSCLC) accounts for more than 85% of lung cancer cases, and despite advancements in therapy, the survival rate for NSCLC patients remains low. miRNAs have been identified as molecules that play a crucial role in tumorigenesis and progression of various cancers, including NSCLC. Dysregulation of miRNAs has been recognized as a causative mechanism in NSCLC tumorigenesis. This review discusses the role of miRNAs in NSCLC tumor progression and their potential as therapeutic biomarkers, highlighting specific miRNAs that could be explored for NSCLC management.
Review
Biochemistry & Molecular Biology
Alina Ioana Scarlatescu, Miruna Mihaela Micheu, Nicoleta-Monica Popa-Fotea, Maria Dorobantu
Summary: MicroRNAs have emerged as promising tools in the field of cardiovascular diseases, with potential in diagnostic, prognostic, and therapeutic applications for patients with ST elevation myocardial infarction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mehrdad Hashemi, Sahar Hasani, Shima Hajimazdarany, Seyed Reza Mirmazloomi, Sara Makvandy, Abbas Zabihi, Yeganeh Goldoost, Nazanin Gholinia, Amirabbas Kakavand, Alireza Tavakolpournegari, Shokooh Salimimoghadam, Noushin Nabavi, Ali Zarrabi, Afshin Taheriazam, Maliheh Entezari, Kiavash Hushmandi
Summary: This article discusses the critical role of non-coding RNAs (ncRNAs) in regulating the Notch signaling pathway in various cancer hallmarks, including proliferation, apoptosis, autophagy, EMT, invasion, metastasis, and resistance to therapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Milosz Pietrus, Michal Seweryn, Przemyslaw Kapusta, Pawel Wolkow, Kazimierz Pitynski, Gracjan Wator
Summary: Endometrial cancer (EC) is treated based on stage and prognostic risk factors. Differences between grades can be distinguished through miRNA profiling, with miR-375 and miR190b being markers that best distinguish high-grade EC from low-grade EC. One possible mechanism for high-grade EC is virus modulation of host morphology or physiology.
Review
Biochemistry & Molecular Biology
Meng-Shin Shiao, Jia-Ming Chang, Arb-Aroon Lertkhachonsuk, Naparat Rermluk, Natini Jinawath
Summary: Early detection of EOC is crucial for improving survival rates. Exosomal miRNAs show promise as non-invasive biomarkers for early cancer detection, but stability, sensitivity, and selection of endogenous reference miRNAs are important considerations. Current clinical trials using miRNAs for EOC detection suggest their potential utility in the future.
Article
Oncology
Ruijie Wu, Bohan Zhang, Mengju He, Yani Kang, Gong Zhang
Summary: Through analyzing miRNA expression profiles in lung cancer tissues, we identified three miRNA composites (hsa-mir-21, hsa-mir-141, and hsa-mir-490) as potential biomarkers for the prognosis of lung cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Ovarian cancer, a heterogeneous disease, is commonly treated with surgery and chemotherapy, but natural products like resveratrol may offer a safe alternative therapy with anticancer effects. Resveratrol, commonly found in human diet, has shown promising results in fighting ovarian cancer cells.
Article
Biochemistry & Molecular Biology
Tingting Yan, Chaoqin Shen, Penglei Jiang, Chenyang Yu, Fangfang Guo, Xianglong Tian, Xiaoqiang Zhu, Shiyuan Lu, Bingshe Han, Ming Zhong, Jinxian Chen, Qiang Liu, Yingxuan Chen, Junfang Zhang, Jie Hong, Haoyan Chen, Jing-Yuan Fang
Summary: The study identified a risk SNP-mediated oncogene lncRNA-SLCC1 that promotes colorectal cancer by activating the glycolysis pathway, with its expression levels associated with patient survival.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Yaashini Rajasegaran, Adam Azlan, Aliaa Arina Rosli, Mot Yee Yik, Khor Kang Zi, Narazah Mohd Yusoff, Emmanuel Jairaj Moses
Summary: MicroRNAs play a crucial role in cancer by regulating various cancer hallmarks such as proliferation, invasion, and metastasis. Understanding the mechanisms of miRNA regulation in different cancer hallmarks can provide insights for utilizing microRNAs as biomarkers and therapeutic targets in cancer research.
Review
Respiratory System
Adrian Constantin, Silviu Constantinoiu, Florin Achim, Bogdan Socea, Daniel Ovidiu Costea, Dragos Predescu
Summary: Esophageal diverticulum is a rare condition that requires a comprehensive diagnostic evaluation and appropriate therapeutic decision-making. Various investigations, including endoscopy and barium swallow, need to be correlated with complex physiological and imaging evaluations for accurate management. Surgical treatment can be challenging due to the risk of complications, and alternative minimally invasive or endoscopic techniques should be explored to improve outcomes.
JOURNAL OF THORACIC DISEASE
(2023)
Review
Medicine, General & Internal
Adelina Popa, Mara Carsote, Dragos Cretoiu, Mihai Cristian Dumitrascu, Claudiu-Eduard Nistor, Florica Sandru
Summary: Thyroid hormones are crucial for the growth and maintenance of hair follicles. This narrative review examines the thyroid profile of patients with different types of alopecia. The presence of autoimmune thyroid diseases suggests a common autoimmune background with alopecia areata (AA). However, routine thyroid screening for AA patients remains controversial. Telogen effluvium (TE) and frontal fibrosing alopecia (FFA) also show associations with thyroid anomalies, but further research is needed to determine the underlying mechanisms. Overall, a multidisciplinary approach combining trichology and endocrinology is necessary to improve the management of alopecia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Adrian Constantin, Florin Achim, Tudor Turcu, Adelina Birceanu, Anca Evsei, Bogdan Socea, Dragos Predescu
Summary: Giant gallbladder is a rare condition, which can result from benign pathology and rarely presents with malignancy. Imaging scans are necessary to evaluate the morphology and loco-regional extension of gallbladder tumors. Although few cases of giant gallbladder cancer have been reported in the literature, this appears to be the largest resectable gallbladder carcinoma reported to date.
Review
Biochemistry & Molecular Biology
Elena-Codruta Cozma, Laura Madalina Banciu, Cristina Soare, Sanda-Maria Cretoiu
Summary: Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer originating from keratinocytes. Multiple risk factors have been identified for the development of cSCC, including UV/ ionizing radiation, chemical carcinogens, immunosuppression, chronic inflammation, viral infections, and genetic alterations. Due to its socio-economic impact and treatment challenges, extensive research has been conducted to understand the molecular mechanisms and advance the therapies for cSCC. This review provides an overview of the molecular, genetic, and epigenetic aspects of cSCC, as well as the treatment methods from conventional to targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Adrian Constantin, Roxana Constantin, Florin Achim, Bogdan Socea, Dragos Predescu
Summary: Cases of digestive cancers diagnosed during pregnancy are rare, but more common in women aged 30-39 years. The diagnosis is difficult due to overlap in symptoms with pregnancy and hesitancy to use invasive investigations. This often leads to late-stage diagnosis and complications. This review focuses on the epidemiology, clinical aspects, paraclinical evaluation, and particularities of diagnosis and treatment of gastric cancer during pregnancy.
Article
Developmental Biology
Alexandra Irma Gabriela Bausic, Sanda Maria Cretoiu, Vasilica Bausic, Daniela Roxana Matasariu, Ruxandra Viorica Stanculescu, Elvira Bratila
Summary: A 33-year-old Caucasian woman with endometriosis presented with pelvic and gastrointestinal symptoms. Intestinal microbiota analysis revealed significant disruption in her microbiome. These findings highlight the intricate bidirectional relationship between microbiota and endometriosis.
ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY
(2023)
Review
Virology
Elena S. Bernad, Florentina Duica, Panagiotis Antoniadis, Andreea Moza, Diana Lungeanu, Marius Craina, Brenda C. Bernad, Edida Maghet, Ingrid-Andrada Vasilache, Anca Laura Maghiari, Diana-Aurora Arnautu, Daniela Iacob
Summary: Maternal fever and perception of reduced fetal movement may be predictive risk factors for adverse pregnancy outcome in cases with congenital SARS-CoV-2 infection.
Review
Virology
Carmen Elena Condrat, Dragos Cretoiu, Viorica Elena Radoi, Dana Mihaela Mihele, Mihaela Tovaru, Cristian Ioan Bordea, Silviu Cristian Voinea, Nicolae Suciu
Summary: This review explores the immunological changes in pregnant women with HPV and aims to uncover strategies for safely modulating the immune system, mitigating adverse pregnancy consequences, and enhancing maternal and child health. It is of significant importance in understanding the risks of HPV infection during pregnancy.
Article
Medicine, General & Internal
Bogdan Mastalier, Victor Cauni, Constantin Tihon, Marius Septimiu Petrutescu, Bogdan Ghita, Valentin Popescu, Dan Andras, Ion Mircea Radu, Vasile Gabriel Vlasceanu, Marius Florian Floroiu, Cristian Draghici, Cristian Botezatu, Dragos Cretoiu, Valentin Nicolae Varlas, Angela Madalina Lazar
Summary: Despite the decrease in mortality rates, morbidity rates following pancreaticoduodenectomy remain significant, particularly in the case of postoperative pancreatic fistula. The ideal type of pancreatic anastomosis and a consensus on the pancreatic fistula risk prediction score are still lacking. Our study identified several significant predictive factors for postoperative fistula occurrence and found that pancreaticogastrostomy has a lower fistula rate compared to pancreaticojejunostomy in patients with risk factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Microbiology
Mihaela Adela Iancu, Monica Profir, Oana Alexandra Rosu, Ruxandra Florentina Ionescu, Sanda Maria Cretoiu, Bogdan Severus Gaspar
Summary: The gut microbiota plays a crucial role in gut health and immune metabolism. Probiotics have the potential to modulate the gut microbiome, strengthen the intestinal barrier, and regulate the immune system, thus offering benefits in treating diarrhea and constipation.
Review
Biochemistry & Molecular Biology
Valentin Popescu, Victor Cauni, Marius Septimiu Petrutescu, Maria Madalina Rustin, Raluca Bocai, Cristina Rachila Turculet, Horia Doran, Traian Patrascu, Angela Madalina Lazar, Dragos Cretoiu, Valentin Nicolae Varlas, Bogdan Mastalier
Summary: This review focuses on chronic wound management, analyzing medical literature from multiple perspectives. The study evaluated 48 articles from the past 21 years and summarized the findings.
Article
Medicine, General & Internal
Iulia Cristina Pirvulescu, Alfred Najm, Eduard Cristian Popa, Alexandru Laurentiu Chiotoroiu, Sanda Maria Cretoiu, Bogdan Severus Gaspar
Summary: Ingested foreign bodies are frequently seen in emergency department visits by patients of all ages. This report describes a unique case of a foreign body in the sigmoid colon that entered through a backstabbing incident and remained without symptoms for 7 years. Surgical intervention was successful in removing the foreign object, and the patient had an uneventful recovery.
Article
Microbiology
Christopher Wallen-Russell, Nancy Pearlman, Samuel Wallen-Russell, Dragos Cretoiu, Dana Claudia Thompson, Silviu Cristian Voinea, Roberto Di Marco, Matthias Noll
Summary: There is a catastrophic loss of biodiversity in ecosystems worldwide, and a similar crisis is observed in the human gut microbiome. The skin microbiome, despite being a crucial part of the body's systems, is often overlooked. Research has shown that dysbiosis of the skin microbiome is linked to many common skin diseases and potentially even whole-body health problems. Biodiversity loss in the skin microbiome is a major contributor to chronic diseases and understanding the link between ecosystem and human health is crucial.
Article
Oncology
Diana Andreea Draghici, Alexandru Rares Stoian, Vlad Andrei Porojan, Oana Ilona David, Stefan Bedereag, Anda Natalia Ciuhu, Andrei Haidar, Dragos Cretoiu, Carmen Elena Condrat, Valentin Titus Grigorean
Summary: The watch and wait approach is a feasible treatment option for patients with complete response post neoadjuvant therapy in distal rectal cancer, but more research and trials are needed before establishing it as the standard of care.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Danni Meng, Songwei Ai, Michail Spanos, Xiaohui Shi, Guoping Li, Dragos Cretoiu, Qiulian Zhou, Junjie Xiao
Summary: Exercise is crucial for maintaining optimal health and treating various diseases, and the human microbiome plays a significant role in overall health. With the advancements in microbiome research, databases have been established to understand its functionality. This review provides an overview of microbiomics and related databases, discusses the impact of exercise on the microbiome and its relevance to disease, and highlights the potential therapeutic implications of an exercise-modulated microbiome in various diseases.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
