The Tubulin Code in Mitosis and Cancer

α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity

(2020) Luísa T. Ferreira et al.   JOURNAL OF CELL BIOLOGY

The tubulin code and its role in controlling microtubule properties and functions

(2020) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Centrosome–nuclear axis repositioning drives the assembly of a bipolar spindle scaffold to ensure mitotic fidelity

(2020) Vanessa Nunes et al.   MOLECULAR BIOLOGY OF THE CELL

Homogeneous multifocal excitation for high-throughput super-resolution imaging

(2020) Dora Mahecic et al.   NATURE METHODS

Cryo-EM structure of VASH1-SVBP bound to microtubules

(2020) Faxiang Li et al.   eLife

Tubulin carboxypeptidase activity of vasohibin-1 inhibits angiogenesis by interfering with endocytosis and trafficking of pro-angiogenic factor receptors

(2020) Miho Kobayashi et al.   ANGIOGENESIS

Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins

(2020) Yulia Steblyanko et al.   EMBO JOURNAL

Over-Expression of βII-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer

(2019) Kseniya Ruksha et al.   Cells

Structural and Molecular Basis for Katanin-Mediated Severing of Glutamylated Microtubules

(2019) Sang Chul Shin et al.   Cell Reports

Coherent-hybrid STED: high contrast sub-diffraction imaging using a bi-vortex depletion beam

(2019) António Pereira et al.   OPTICS EXPRESS

Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration

(2019) Bertille Bance et al.   JOURNAL OF CELL SCIENCE

Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis

(2019) Shanhui Liao et al.   CELL RESEARCH

Defective tubulin detyrosination causes structural brain abnormalities with cognitive deficiency in humans and mice

(2019) Alistair T Pagnamenta et al.   HUMAN MOLECULAR GENETICS

Structural basis of tubulin detyrosination by vasohibins

(2019) Faxiang Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of tubulin detyrosination by the vasohibin–SVBP enzyme complex

(2019) Na Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into tubulin detyrosination by vasohibins-SVBP complex

(2019) Xi Liu et al.   Cell Discovery

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Human β-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability

(2018) Shih-Chieh Ti et al.   DEVELOPMENTAL CELL

Kinesin-5 Regulation and Function in Mitosis

(2018) Barbara J. Mann et al.   TRENDS IN CELL BIOLOGY

An Emerging Role for Tubulin Isotypes in Modulating Cancer Biology and Chemotherapy Resistance

(2017) Amelia L. Parker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Erratum: Microtubule minus-end regulation at spindle poles by an ASPM–katanin complex

(2017) Kai Jiang et al.   NATURE CELL BIOLOGY

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

(2017) Chrystelle Aillaud et al.   SCIENCE

Vasohibins encode tubulin detyrosinating activity

(2017) Joppe Nieuwenhuis et al.   SCIENCE

Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport

(2017) Daniel J. Barbosa et al.   PLoS Genetics

HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma

(2016) Zhihao Wang et al.   CANCER LETTERS

Graded Control of Microtubule Severing by Tubulin Glutamylation

(2016) Max L. Valenstein et al.   CELL

Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility

(2016) Richard J McKenney et al.   EMBO JOURNAL

Loss of α-Tubulin Acetylation Is Associated with TGF-β-induced Epithelial-Mesenchymal Transition

(2016) Shuchen Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structured core of human β tubulin confers isotype-specific polymerization properties

(2016) Melissa C. Pamula et al.   JOURNAL OF CELL BIOLOGY

High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation

(2016) Lauren M. Zasadil et al.   MOLECULAR BIOLOGY OF THE CELL

Evidence for new C-terminally truncated variants of α- and β-tubulins

(2016) Chrystelle Aillaud et al.   MOLECULAR BIOLOGY OF THE CELL

The Tubulin Code: A Navigation System for Chromosomes during Mitosis

(2016) Marin Barisic et al.   TRENDS IN CELL BIOLOGY

α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons

(2016) Jeffrey J. Nirschl et al.   Cell Reports

Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway

(2015) Anna A. Ye et al.   CURRENT BIOLOGY

Spatial Regulation of Kinetochore Microtubule Attachments by Destabilization at Spindle Poles in Meiosis I

(2015) Lukáš Chmátal et al.   CURRENT BIOLOGY

Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization

(2015) Olga I. Kahn et al.   MOLECULAR BIOLOGY OF THE CELL

 III-Tubulin Regulates Breast Cancer Metastases to the Brain

(2015) D. Kanojia et al.   MOLECULAR CANCER THERAPEUTICS

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation

(2015) K.V. Woan et al.   Molecular Oncology

Microtubule detyrosination guides chromosomes during mitosis

(2015) M. Barisic et al.   SCIENCE

βIII-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer

(2015) Joshua A. McCarroll et al.   Oncotarget

 -Tubulin Acetylation Elevated in Metastatic and Basal-like Breast Cancer Cells Promotes Microtentacle Formation, Adhesion, and Invasive Migration

(2014) A. E. Boggs et al.   CANCER RESEARCH

Tumor suppressor roles of CENP-E and Nsl1 inDrosophilaepithelial tissues

(2014) Marta Clemente-Ruiz et al.   CELL CYCLE

Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon

(2014) C. Rocha et al.   EMBO JOURNAL

The tubulin code: Molecular components, readout mechanisms, and functions

(2014) Carsten Janke   JOURNAL OF CELL BIOLOGY

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids

(2014) Olivia Tort et al.   MOLECULAR BIOLOGY OF THE CELL

α-Tubulin K40 acetylation is required for contact inhibition of proliferation and cell–substrate adhesion

(2014) Andrea Aguilar et al.   MOLECULAR BIOLOGY OF THE CELL

Vasohibin-2 modulates tumor onset in the gastrointestinal tract by normalizing tumor angiogenesis

(2014) Shuji Kitahara et al.   Molecular Cancer

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces

(2014) Marin Barisic et al.   NATURE CELL BIOLOGY

Prime movers: the mechanochemistry of mitotic kinesins

(2014) Robert A. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells

(2014) Dengwen Li et al.   Protein & Cell

HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth

(2013) S. A. Gradilone et al.   CANCER RESEARCH

In vivodelivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer

(2013) Takahiro Koyanagi et al.   CANCER SCIENCE

αTAT1 catalyses microtubule acetylation at clathrin-coated pits

(2013) Guillaume Montagnac et al.   NATURE

Katanin p60 Contributes to Microtubule Instability around the Midbody and Facilitates Cytokinesis in Rat Cells

(2013) Moe Matsuo et al.   PLoS One

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

(2013) A. D. Silk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation

(2012) Jonne A Raaijmakers et al.   EMBO JOURNAL

ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion

(2012) Antonio Castro-Castro et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The vasohibin family: a novel family for angiogenesis regulation

(2012) Y. Sato   JOURNAL OF BIOCHEMISTRY

Cortical dynein is critical for proper spindle positioning in human cells

(2012) Sachin Kotak et al.   JOURNAL OF CELL BIOLOGY

MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment

(2012) Sarah B. Domnitz et al.   JOURNAL OF CELL BIOLOGY

Vasohibin-2 Expressed in Human Serous Ovarian Adenocarcinoma Accelerates Tumor Growth by Promoting Angiogenesis

(2012) Y. Takahashi et al.   MOLECULAR CANCER RESEARCH

Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma

(2012) X Xue et al.   ONCOGENE

Luminal Localization of α-tubulin K40 Acetylation by Cryo-EM Analysis of Fab-Labeled Microtubules

(2012) Virupakshi Soppina et al.   PLoS One

Timing of centrosome separation is important for accurate chromosome segregation

(2011) William T. Silkworth et al.   MOLECULAR BIOLOGY OF THE CELL

Cortical Constriction During Abscission Involves Helices of ESCRT-III-Dependent Filaments

(2011) J. Guizetti et al.   SCIENCE

Endogenous Angiogenesis Inhibitor Vasohibin1 Exhibits Broad-Spectrum Antilymphangiogenic Activity and Suppresses Lymph Node Metastasis

(2010) Takahiro Heishi et al.   AMERICAN JOURNAL OF PATHOLOGY

O-GlcNAcylation of tubulin inhibits its polymerization

(2010) Suena Ji et al.   AMINO ACIDS

βIII-Tubulin Is a Multifunctional Protein Involved in Drug Sensitivity and Tumorigenesis in Non–Small Cell Lung Cancer

(2010) Joshua A. McCarroll et al.   CANCER RESEARCH

Epithelial-to-Mesenchymal Transition Promotes Tubulin Detyrosination and Microtentacles that Enhance Endothelial Engagement

(2010) R. A. Whipple et al.   CANCER RESEARCH

Involvement of the Tubulin Tyrosine Ligase-Like Family Member 4 Polyglutamylase in PELP1 Polyglutamylation and Chromatin Remodeling in Pancreatic Cancer Cells

(2010) K. Kashiwaya et al.   CANCER RESEARCH

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E

(2010) Yumi Kim et al.   CELL

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

HDAC6 is required for invadopodia activity and invasion by breast tumor cells

(2010) Mercedes Rey et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Identification of Tubulin Deglutamylase amongCaenorhabditis elegansand Mammalian Cytosolic Carboxypeptidases (CCPs)

(2010) Yoshishige Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

(2010) Benjamin Lacroix et al.   JOURNAL OF CELL BIOLOGY

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation

(2010) Chih-Wen Chu et al.   MOLECULAR BIOLOGY OF THE CELL

MEC-17 is an α-tubulin acetyltransferase

(2010) Jyothi S. Akella et al.   NATURE

The major  -tubulin K40 acetyltransferase  TAT1 promotes rapid ciliogenesis and efficient mechanosensation

(2010) T. Shida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vasohibin-1 Expression in Endothelium of Tumor Blood Vessels Regulates Angiogenesis

(2009) Tomoko Hosaka et al.   AMERICAN JOURNAL OF PATHOLOGY

Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis

(2009) Hiroshi Kimura et al.   BLOOD

Evolutionary Divergence of Enzymatic Mechanisms for Posttranslational Polyglycylation

(2009) Krzysztof Rogowski et al.   CELL

Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability

(2009) Samuel F. Bakhoum et al.   CURRENT BIOLOGY

TTLL3 Is a Tubulin Glycine Ligase that Regulates the Assembly of Cilia

(2009) Dorota Wloga et al.   DEVELOPMENTAL CELL

Motor-dependent microtubule disassembly driven by tubulin tyrosination

(2009) Leticia Peris et al.   JOURNAL OF CELL BIOLOGY

Spindle orientation during asymmetric cell division

(2009) Karsten H. Siller et al.   NATURE CELL BIOLOGY

Tubulin tyrosination navigates the kinesin-1 motor domain to axons

(2009) Yoshiyuki Konishi et al.   NATURE NEUROSCIENCE

The Cytoplasmic Deacetylase HDAC6 Is Required for Efficient Oncogenic Tumorigenesis

(2008) Y.-S. Lee et al.   CANCER RESEARCH

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

(2008) Samuel F. Bakhoum et al.   NATURE CELL BIOLOGY

Spastin Couples Microtubule Severing to Membrane Traffic in Completion of Cytokinesis and Secretion

(2008) James W. Connell et al.   TRAFFIC