The Multimodal Serotonergic Agent Vilazodone Inhibits L-DOPA-Induced Gene Regulation in Striatal Projection Neurons and Associated Dyskinesia in an Animal Model of Parkinson’s Disease

Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats

(2020) Kathy Steece-Collier et al.   EXPERIMENTAL NEUROLOGY

Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia

(2019) Rhyomi C. Sellnow et al.   Acta Neuropathologica Communications

Optostimulation of striatonigral terminals in substantia nigra induces dyskinesia that increases after L‐DOPA in a mouse model of Parkinson's disease

(2019) Ettel Keifman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias

(2019) Fernando E. Padovan-Neto et al.   MOLECULAR NEUROBIOLOGY

Serotonergic targets for the treatment of l-DOPA-induced dyskinesia

(2018) Kathryn Lanza et al.   JOURNAL OF NEURAL TRANSMISSION

Signal transduction in l-DOPA-induced dyskinesia: from receptor sensitization to abnormal gene expression

(2018) Giada Spigolon et al.   JOURNAL OF NEURAL TRANSMISSION

The serotonergic system in L-DOPA-induced dyskinesia: pre-clinical evidence and clinical perspective

(2018) Manolo Carta et al.   JOURNAL OF NEURAL TRANSMISSION

Pathophysiology of dyskinesia and behavioral disorders in non-human primates: the role of serotonergic fibers

(2018) Véronique Sgambato et al.   JOURNAL OF NEURAL TRANSMISSION

A Subpopulation of Striatal Neurons Mediates Levodopa-Induced Dyskinesia

(2018) Allison E. Girasole et al.   NEURON

Diverse serotonin actions of vilazodone reduce l-3,4-dihidroxyphenylalanine-induced dyskinesia in hemi-parkinsonian rats

(2018) Samantha M. Meadows et al.   MOVEMENT DISORDERS

Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson’s disease therapy

(2017) Cristina Alcacer et al.   JOURNAL OF CLINICAL INVESTIGATION

Striatal activation by optogenetics induces dyskinesias in the 6-hydroxydopamine rat model of Parkinson disease

(2017) Ledia F. Hernández et al.   MOVEMENT DISORDERS

L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia

(2016) Luz M Suarez et al.   CEREBRAL CORTEX

Frequency-Dependent Corticostriatal Disinhibition Resulting from Chronic Dopamine Depletion: Role of Local Striatal cGMP and GABA-AR Signaling

(2015) Vatsala R. Jayasinghe et al.   CEREBRAL CORTEX

Fluoxetine potentiation of methylphenidate-induced gene regulation in striatal output pathways: Potential role for 5-HT1B receptor

(2015) Vincent Van Waes et al.   NEUROPHARMACOLOGY

Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of l-DOPA-induced dyskinesia in 6-OHDA-lesioned rats

(2015) Fernando Eduardo Padovan-Neto et al.   NEUROPHARMACOLOGY

The highly-selective 5-HT1A agonist F15599 reduces l-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque

(2015) Philippe Huot et al.   NEUROPHARMACOLOGY

Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson’s disease

(2015) C. Fidalgo et al.   NEUROSCIENCE

Side effect profile of 5-HT treatments for Parkinson's disease and L-DOPA-induced dyskinesia in rats

(2014) D Lindenbach et al.   BRITISH JOURNAL OF PHARMACOLOGY

Serotonergic mechanisms responsible for levodopa-induced dyskinesias in Parkinson’s disease patients

(2014) Marios Politis et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia

(2014) M. Heiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism

(2014) Erik Södersten et al.   PLoS Genetics

Effects of prolonged selective serotonin reuptake inhibition on the development and expression of l-DOPA-induced dyskinesia in hemi-parkinsonian rats

(2013) Melissa M. Conti et al.   NEUROPHARMACOLOGY

Serotonin transporter inhibition attenuatesl-DOPA-induced dyskinesia without compromisingl-DOPA efficacy in hemi-parkinsonian rats

(2012) Christopher Bishop et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

In vivo evidence for a differential contribution of striatal and nigral D1 and D2 receptors to l-DOPA induced dyskinesia and the accompanying surge of nigral amino acid levels

(2011) Flora Mela et al.   NEUROBIOLOGY OF DISEASE

Inhibition of Striatal Soluble Guanylyl Cyclase-cGMP Signaling Reverses Basal Ganglia Dysfunction and Akinesia in Experimental Parkinsonism

(2011) Kuei Y. Tseng et al.   PLoS One

Glutamatergic mechanisms in the dyskinesias induced by pharmacological dopamine replacement and deep brain stimulation for the treatment of Parkinson's disease

(2011) Véronique Sgambato-Faure et al.   PROGRESS IN NEUROBIOLOGY

Striatal Signaling in L-DOPA-Induced Dyskinesia: Common Mechanisms with Drug Abuse and Long Term Memory Involving D1 Dopamine Receptor Stimulation

(2011) Mario Gustavo Murer et al.   Frontiers in Neuroanatomy

Serotonergic neurons mediate ectopic release of dopamine induced by l-DOPA in a rat model of Parkinson's disease

(2010) Sylvia Navailles et al.   NEUROBIOLOGY OF DISEASE

l-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson’s disease: temporal and quantitative relationship to the expression of dyskinesia

(2009) Hanna S. Lindgren et al.   JOURNAL OF NEUROCHEMISTRY

Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats

(2009) Christopher Bishop et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: Common implication of striatal neuropeptides

(2009) Mohamed Khalil Tamim et al.   NEUROPHARMACOLOGY

The role of the dorsal raphe nucleus in the development, expression, and treatment of L-dopa-induced dyskinesia in hemiparkinsonian rats

(2009) Karen L. Eskow et al.   SYNAPSE

Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia

(2008) A. Munoz et al.   BRAIN