Signal transduction in l-DOPA-induced dyskinesia: from receptor sensitization to abnormal gene expression

cJun N-terminal kinase (JNK) mediates cortico-striatal signaling in a model of Parkinson's disease

(2018) Giada Spigolon et al.   NEUROBIOLOGY OF DISEASE

Dopamine-Induced Changes in Gαolf Protein Levels in Striatonigral and Striatopallidal Medium Spiny Neurons Underlie the Genesis of l-DOPA-Induced Dyskinesia in Parkinsonian Mice

(2017) Ryoma Morigaki et al.   Frontiers in Cellular Neuroscience

Antidyskinetic Effects of MEK Inhibitor Are Associated with Multiple Neurochemical Alterations in the Striatum of Hemiparkinsonian Rats

(2017) Guiqin Chen et al.   Frontiers in Neuroscience

A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA –Induced Dyskinesia and ∆FosB Expression

(2016) Michael Feyder et al.   BIOLOGICAL PSYCHIATRY

Selective Inactivation of Striatal FosB/ΔFosB-Expressing Neurons Alleviates L-DOPA–Induced Dyskinesia

(2016) Michel Engeln et al.   BIOLOGICAL PSYCHIATRY

L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia

(2016) Luz M Suarez et al.   CEREBRAL CORTEX

Dynamic DNA Methylation Regulates Levodopa-Induced Dyskinesia

(2016) David A. Figge et al.   JOURNAL OF NEUROSCIENCE

Shp-2 knockdown preventsl-dopa-induced dyskinesia in a rat model of Parkinson's disease

(2016) Chiara Fiorentini et al.   MOVEMENT DISORDERS

Hyperkinetic disorders and loss of synaptic downscaling

(2016) Paolo Calabresi et al.   NATURE NEUROSCIENCE

Gadd45β ameliorates L-DOPA-induced dyskinesia in a Parkinson's disease mouse model

(2016) Hye-Yeon Park et al.   NEUROBIOLOGY OF DISEASE

Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesias

(2016) Tanuja Bordia et al.   NEUROBIOLOGY OF DISEASE

Activation of DREAM (Downstream Regulatory Element Antagonistic Modulator), a Calcium-Binding Protein, Reduces L-DOPA-Induced Dyskinesias in Mice

(2015) Irene Ruiz-DeDiego et al.   BIOLOGICAL PSYCHIATRY

Overexpression of GRK6 rescues l-DOPA-induced signaling abnormalities in the dopamine-depleted striatum of hemiparkinsonian rats

(2015) M. Rafiuddin Ahmed et al.   EXPERIMENTAL NEUROLOGY

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)

(2015) Lingyong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic Views of Transcriptional Enhancers: Essential Determinants of Cellular Identity and Activity-Dependent Responses in the CNS

(2015) J. M. Gray et al.   JOURNAL OF NEUROSCIENCE

Gene Expression Analyses Identify Narp Contribution in the Development of L-DOPA-Induced Dyskinesia

(2015) F. Charbonnier-Beaupel et al.   JOURNAL OF NEUROSCIENCE

Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum

(2015) I. Ruiz-DeDiego et al.   MOVEMENT DISORDERS

DNA methylation changes in plasticity genes accompany the formation and maintenance of memory

(2015) Rashi Halder et al.   NATURE NEUROSCIENCE

D1 dopamine receptor stimulation impairs striatal proteasome activity in Parkinsonism through 26S proteasome disassembly

(2015) Pedro Barroso-Chinea et al.   NEUROBIOLOGY OF DISEASE

Enhanced histamine H2 excitation of striatal cholinergic interneurons in l-DOPA-induced dyskinesia

(2015) Sean Austin O. Lim et al.   NEUROBIOLOGY OF DISEASE

Stamping out RAF and MEK1/2 to inhibit the ERK1/2 pathway: an emerging threat to anticancer therapy

(2015) R Mandal et al.   ONCOGENE

Targeting β-arrestin2 in the treatment of l-DOPA–induced dyskinesia in Parkinson’s disease

(2015) Nikhil M. Urs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson’s disease via its RGS homology domain

(2015) Mohamed R. Ahmed et al.   Scientific Reports

Inhibition of Adenylyl Cyclase Type 5 Prevents L-DOPA-Induced Dyskinesia in an Animal Model of Parkinson's Disease

(2014) H.-Y. Park et al.   JOURNAL OF NEUROSCIENCE

Striatal Cholinergic Cell Ablation Attenuates L-DOPA Induced Dyskinesia in Parkinsonian Mice

(2014) L. Won et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of Dopamine D1 Receptor-Mediated ERK1/2 Activation in the Parkinsonian Striatum and Their Modulation by Metabotropic Glutamate Receptor Type 5

(2014) T. Fieblinger et al.   JOURNAL OF NEUROSCIENCE

Genome-wide identification and characterization of functional neuronal activity–dependent enhancers

(2014) Athar N Malik et al.   NATURE NEUROSCIENCE

Selective loss of bi-directional synaptic plasticity in the direct and indirect striatal output pathways accompanies generation of parkinsonism and l-DOPA induced dyskinesia in mouse models

(2014) Sherri L. Thiele et al.   NEUROBIOLOGY OF DISEASE

RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease

(2014) Wai Kin D. Ko et al.   NEUROBIOLOGY OF DISEASE

Mitogen- and stress-activated protein kinase 1 is required for specific signaling responses in dopamine-denervated mouse striatum, but is not necessary for l-DOPA-induced dyskinesia

(2014) Cristina Alcacer et al.   NEUROSCIENCE LETTERS

Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia

(2014) M. Heiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism

(2014) Erik Södersten et al.   PLoS Genetics

L-DOPA Treatment Selectively Restores Spine Density in Dopamine Receptor D2–Expressing Projection Neurons in Dyskinetic Mice

(2013) Luz M. Suárez et al.   BIOLOGICAL PSYCHIATRY

Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease

(2013) Chiara Fiorentini et al.   NEUROBIOLOGY OF DISEASE

Immediate-early gene expression in structures outside the basal ganglia is associated to l-DOPA-induced dyskinesia

(2013) Matthieu F. Bastide et al.   NEUROBIOLOGY OF DISEASE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Dopamine- and cAMP-regulated Phosphoprotein of 32-kDa (DARPP-32)-dependent Activation of Extracellular Signal-regulated Kinase (ERK) and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Experimental Parkinsonism

(2012) Emanuela Santini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PSD-95 expression controls l-DOPA dyskinesia through dopamine D1 receptor trafficking

(2012) Gregory Porras et al.   JOURNAL OF CLINICAL INVESTIGATION

L-DOPA Impairs Proteasome Activity in Parkinsonism through D1 Dopamine Receptor

(2012) A. Berthet et al.   JOURNAL OF NEUROSCIENCE

G olf Mutation Allows Parsing the Role of cAMP-Dependent and Extracellular Signal-Regulated Kinase-Dependent Signaling in L-3,4-Dihydroxyphenylalanine-Induced Dyskinesia

(2012) C. Alcacer et al.   JOURNAL OF NEUROSCIENCE

CpG islands and the regulation of transcription

(2011) A. M. Deaton et al.   GENES & DEVELOPMENT

The tyrosine phosphatase Shp-2 interacts with the dopamine D1 receptor and triggers D1-mediated Erk signaling in striatal neurons

(2011) Chiara Fiorentini et al.   JOURNAL OF NEUROCHEMISTRY

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia

(2011) Srinivasa Subramaniam et al.   NATURE NEUROSCIENCE

Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation

(2011) K. Ramamoorthi et al.   SCIENCE

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

(2010) Quincey LaPlant et al.   NATURE NEUROSCIENCE

Striatal inhibition of PKA prevents levodopa-induced behavioural and molecular changes in the hemiparkinsonian rat

(2010) Manon Lebel et al.   NEUROBIOLOGY OF DISEASE

Distinct Changes in cAMP and Extracellular Signal-Regulated Protein Kinase Signalling in L-DOPA-Induced Dyskinesia

(2010) Emanuela Santini et al.   PLoS One

Alterations in mGluR5 Expression and Signaling in Lewy Body Disease and in Transgenic Models of Alpha-Synucleinopathy – Implications for Excitotoxicity

(2010) Diana L. Price et al.   PLoS One

Arc regulates spine morphology and maintains network stability in vivo

(2010) C. L. Peebles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in parkinsonian mice

(2010) Y. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors

(2010) H. S. Bateup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia

(2010) S. Fasano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lentiviral Overexpression of GRK6 Alleviates L-Dopa-Induced Dyskinesia in Experimental Parkinson's Disease

(2010) M. R. Ahmed et al.   Science Translational Medicine

Striatal Overexpression of ΔJunD Resets L-DOPA-Induced Dyskinesia in a Primate Model of Parkinson Disease

(2009) Olivier Berton et al.   BIOLOGICAL PSYCHIATRY

Genetic Inactivation of Dopamine D1 but Not D2 Receptors Inhibits L-DOPA–Induced Dyskinesia and Histone Activation

(2009) Sanja Darmopil et al.   BIOLOGICAL PSYCHIATRY

Pharmacological Analysis Demonstrates Dramatic Alteration of D1 Dopamine Receptor Neuronal Distribution in the Rat Analog of L-DOPA-Induced Dyskinesia

(2009) A. Berthet et al.   JOURNAL OF NEUROSCIENCE

PSD-95 Uncouples Dopamine-Glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex

(2009) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Modulation of Glutamate Transmission in a Rat Model of L-DOPA-Induced Dyskinesia: Effects on Motor Behavior and Striatal Nuclear Signaling

(2009) D. Rylander et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

De novo and long-term l-Dopa induce both common and distinct striatal gene profiles in the hemiparkinsonian rat

(2009) Michèle El Atifi-Borel et al.   NEUROBIOLOGY OF DISEASE

Evaluation of the D3 dopamine receptor selective antagonist PG01037 on l-dopa-dependent abnormal involuntary movements in rats

(2009) Rakesh Kumar et al.   NEUROPHARMACOLOGY

The selective D3 receptor antagonist, S33084, improves parkinsonian-like motor dysfunction but does not affect l-DOPA-induced dyskinesia in 6-hydroxydopamine hemi-lesioned rats

(2009) Flora Mela et al.   NEUROPHARMACOLOGY

Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy

(2009) Jill R. Crittenden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia

(2009) E. Santini et al.   Science Signaling

Identification of Dopamine D1–D3Receptor Heteromers

(2008) Daniel Marcellino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

l-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice

(2008) Emanuela Santini et al.   JOURNAL OF NEUROCHEMISTRY

Differences between Dorsal and Ventral Striatum in Drd1a Dopamine Receptor Coupling of Dopamine- and cAMP-Regulated Phosphoprotein-32 to Activation of Extracellular Signal-Regulated Kinase

(2008) C. R. Gerfen et al.   JOURNAL OF NEUROSCIENCE

Induction of Activating Transcription Factors (ATFs) ATF2, ATF3, and ATF4 in the Nucleus Accumbens and Their Regulation of Emotional Behavior

(2008) T. A. Green et al.   JOURNAL OF NEUROSCIENCE

The 3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibitor Lovastatin Reduces Severity of L-DOPA-Induced Abnormal Involuntary Movements in Experimental Parkinson's Disease

(2008) S. Schuster et al.   JOURNAL OF NEUROSCIENCE

Reciprocal Regulation of Dopamine D1 and D3 Receptor Function and Trafficking by Heterodimerization

(2008) C. Fiorentini et al.   MOLECULAR PHARMACOLOGY

Dopamine D3 receptor stimulation underlies the development of L-DOPA-induced dyskinesia in animal models of Parkinson's disease

(2008) Naomi P. Visanji et al.   NEUROBIOLOGY OF DISEASE

DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity

(2007) Courtney A. Miller et al.   NEUROBIOLOGY OF LEARNING AND MEMORY