Nuclear Heparanase Regulates Chromatin Remodeling, Gene Expression and PTEN Tumor Suppressor Function

Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance

(2019) Daiana Vitale et al.   FEBS Journal

Heparanase promotes myeloma stemness and in vivo tumorigenesis

(2019) Kaushlendra Tripathi et al.   MATRIX BIOLOGY

Multiple myeloma cells adapted to long-exposure of hypoxia exhibit stem cell characters with TGF-β/Smad pathway activation

(2018) Yoko Nakagawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Maintenance and continuous therapy for multiple myeloma

(2018) Paul G. Richardson et al.   Expert Review of Anticancer Therapy

Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival

(2018) Andrew Baker et al.   ONCOGENE

Effects of microRNA‑20a on the proliferation, migration and apoptosis of multiple myeloma via the PTEN/PI3K/AKT signaling pathway

(2018) Yanxia Jiang et al.   Oncology Letters

Cell Cycle Control by PTEN

(2017) Andrew Brandmaier et al.   JOURNAL OF MOLECULAR BIOLOGY

Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1

(2017) Alex M. Agelidis et al.   Cell Reports

MicroRNA-19a functions as an oncogene by regulating PTEN/AKT/pAKT pathway in myeloma

(2016) Xiaoying Zhang et al.   LEUKEMIA & LYMPHOMA

Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype

(2016) Vishnu C. Ramani et al.   MATRIX BIOLOGY

PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN

(2016) Jianbo Xiong et al.   ONCOLOGY REPORTS

PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

(2016) Swapnil Rohidas Shinde et al.   Nature Communications

PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells

(2016) Camila S. Matsumoto et al.   Oncotarget

Myeloma cell-derived Runx2 promotes myeloma progression in bone

(2015) T. N. Trotter et al.   BLOOD

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

(2015) Bart Roucourt et al.   CELL RESEARCH

Study of PTEN subcellular localization

(2015) Angela Bononi et al.   METHODS

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

(2015) Shunlei Duan et al.   Nature Communications

MicroRNA-451 regulates stemness of side population cells via PI3K/Akt/mTOR signaling pathway in multiple myeloma

(2015) Juan Du et al.   Oncotarget

Notch signaling deregulation in multiple myeloma: A rational molecular target

(2015) Michela Colombo et al.   Oncotarget

Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN

(2015) Hoai-Nghia Nguyen et al.   Scientific Reports

PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression

(2014) Ling-Li Zhang et al.   CELLULAR SIGNALLING

Endothelial Cell Heparanase Taken Up by Cardiomyocytes Regulates Lipoprotein Lipase Transfer to the Coronary Lumen After Diabetes

(2014) Y. Wang et al.   DIABETES

Shed Syndecan-1 Translocates to the Nucleus of Cells Delivering Growth Factors and Inhibiting Histone Acetylation

(2014) Mark D. Stewart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTEN Loss-Mediated Akt Activation Increases the Properties of Cancer Stem-Like Cell Populations in Prostate Cancer

(2014) Ran-Ju Kim et al.   ONCOLOGY

PTEN Interacts with Histone H1 and Controls Chromatin Condensation

(2014) Zhu Hong Chen et al.   Cell Reports

Methylation analysis of the phosphates and tensin homologue on chromosome 10 gene (PTEN) in multiple myeloma

(2014) Giovanna Piras et al.   Clinical Epigenetics

Characterization of Heparanase-induced Phosphatidylinositol 3-Kinase-AKT Activation and Its Integrin Dependence

(2013) Anjum Riaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes

(2013) Camilla A. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation

(2013) C.R. Parish et al.   MATRIX BIOLOGY

Heparan sulfate in the nucleus and its control of cellular functions

(2013) Mark D. Stewart et al.   MATRIX BIOLOGY

Fatty Acid-Induced Nuclear Translocation of Heparanase Uncouples Glucose Metabolism in Endothelial Cells

(2011) Fang Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype

(2011) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival

(2011) S Ammoun et al.   ONCOGENE

Heparanase Enhances Local and Systemic Osteolysis in Multiple Myeloma by Upregulating the Expression and Secretion of RANKL

(2010) Y. Yang et al.   CANCER RESEARCH

Effect of wild type PTEN gene on proliferation and invasion of multiple myeloma

(2010) Suyun Wang et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Physical and Functional HAT/HDAC Interplay Regulates Protein Acetylation Balance

(2010) Alessia Peserico et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6

(2009) R. E. Tiedemann et al.   BLOOD

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Heparanase Regulates Levels of Syndecan-1 in the Nucleus

(2009) Ligong Chen et al.   PLoS One

Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment

(2008) Ghada Abboud-Jarrous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma

(2008) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedgehog Signaling Regulates Brain Tumor-Initiating Cell Proliferation and Portends Shorter Survival for Patients with PTEN-Coexpressing Glioblastomas

(2008) Qijin Xu et al.   STEM CELLS