Article
Urology & Nephrology
Bruce J. Trock, Yuezhou Jing, Brent Mabey, Zaina Sangale, Lauren Lenz, Nora Haney, Igor Vidal, Stephanie A. Glavaris, Gunes Guner, Onur Ertunc, Ibrahim Kulac, Javier A. Baena Del Valle, Tracy Jones, Misop Han, Alan W. Partin, Todd Cohen, Steven Stone, Angelo M. De Marzo
Summary: The study showed that cell-cycle progression was independently associated with metastasis-free survival in prostate cancer patients, particularly those receiving salvage radiotherapy, while phosphatase and tensin homolog had weaker correlation with metastasis after adjustment for post-surgical risk assessment.
JOURNAL OF UROLOGY
(2022)
Article
Multidisciplinary Sciences
Jiajia Xu, Zhao Li, Robert J. Tower, Stefano Negri, Yiyun Wang, Carolyn A. Meyers, Takashi Sono, Qizhi Qin, Amy Lu, Xin Xing, Edward F. McCarthy, Thomas L. Clemens, Aaron W. James
Summary: Bone regeneration following injury is coordinated by inflammatory signals and sensory nerve infiltration. This study demonstrates that nerve growth factor (NGF) signals through p75 to affect migration of mesenchymal osteogenic precursors, thereby impacting bone healing. Lack of NGF or p75 results in delayed bone repair.
Article
Oncology
Changze Song, Jianong Zhang, Xiao Liu, Meilu Li, Dejie Wang, Zhijian Kang, Jiaao Yu, Jiuwei Chen, Hongxin Pan, Honglei Wang, Guangbin Li, Haojie Huang
Summary: PTEN can suppress the Warburg effect in prostate cancer (PCa) by regulating the expression of fructose-1,6-bisphosphatase (FBP1). PTEN regulates FBP1 expression through the PI3K/AKT signal pathway, and the degradation of FBP1 protein depends on the phosphorylation of serine 271 by cyclin-dependent kinases (CDKs) and the mediation of SKP2 E3 ubiquitin ligase. The loss of PTEN expression enhances the Warburg effect and promotes PCa growth.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiaojiang Liu, Yiqiu Cui, Jun Li, Cheng Guan, Shu Cai, Jinrong Ding, Jianhong Shen, Yixiang Guan
Summary: PTEN inhibitor bpv(pic) promotes the proliferation and differentiation of NSCs into neurons by regulating the expression and phosphorylation of the Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zoe N. Loh, Mu-En Wang, Changxin Wan, John M. Asara, Zhicheng Ji, Ming Chen
Summary: PTEN regulates various biological processes including metabolism through distinct molecular targets in different subcellular compartments. While its role in cytosol is well-studied, the metabolic regulation of PTEN in the nucleus is yet unknown. This study reveals that nuclear PTEN contributes to pyrimidine metabolism, specifically de novo thymidylate biosynthesis, through interaction with MTHFD1. The findings provide insight into the nuclear function of PTEN and have potential implications for targeted therapy in nuclear-excluded PTEN prostate cancer cells with antifolate drugs.
Article
Cell Biology
Angela Russo, Jose A. Colina, Junlone Moy, Seth Baligod, Austin A. Czarnecki, Peter Varughese, Daniel D. Lantvit, Matthew J. Dean, Joanna E. Burdette
Summary: Loss of PTEN in FTE leads to enrichment of cancer stem cell markers and altered cell function, while loss of PAX2 plays a crucial role in this process. Additionally, PTEN loss generates two distinct subpopulations of cells with different cancer stem-like cell marker expression and chemoresistance profiles.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Manqi Zhang, Yasemin Ceyhan, Shenglin Mei, Taghreed Hirz, David B. Sykes, Irina U. Agoulnik
Summary: Prostate cancer is driven by multiple genetic alterations, and the loss of INPP4B and PTEN is a common tumor suppressor loss in prostate cancer. The loss of INPP4B and PTEN triggers different compensatory responses in prostate tissue.
Article
Biology
Alexandre A. Germanos, Sonali Arora, Ye Zheng, Erica T. Goddard, Ilsa M. Coleman, Anson T. Ku, Scott Wilkinson, Hanbing Song, Nicholas J. Brady, Robert A. Amezquita, Michael Zager, Annalysa Long, Yu Chi Yang, Jason H. Bielas, Raphael Gottardo, David S. Rickman, Franklin W. Huang, Cyrus M. Ghajar, Peter S. Nelson, Adam G. Sowalsky, Manu Setty, Andrew C. Hsieh
Summary: In this study, we found that the expansion of castration-resistant intermediate luminal cells is associated with treatment resistance and poor prognosis in prostate cancer. The transformed epithelial cells and associated fibroblasts create a microenvironment that promotes pro-tumorigenic immune infiltration, which is influenced by androgen levels. Androgen-independent prostate cancer leads to significant diversification of intermediate luminal cell populations with varying androgen signaling activities, which are inversely correlated with proliferation and mRNA translation. The findings suggest that targeting translation inhibition could potentially lead to epithelial cell death, loss of pro-tumorigenic signaling, and decreased tumor heterogeneity.
Article
Multidisciplinary Sciences
Lu Cui, Ignacio Moraga, Tristan Lerbs, Camille Van Neste, Stephan Wilmes, Naotaka Tsutsumi, Aaron Claudius Trotman-Grant, Milica Gakovic, Sarah Andrews, Jason Gotlib, Spyros Darmanis, Martin Enge, Stephen Quake, Ian S. Hitchcock, Jacob Piehler, K. Christopher Garcia, Gerlinde Wernig
Summary: The study developed a series of surrogate protein ligands that can modulate TPO-R signaling, preserving HSC properties and inhibiting oncogenic signaling through TPO-R by tuning downstream responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Yaser Gamallat, Hend Zaaluk, Ealia Khosh Kish, Ramy Abdelsalam, Konstantinos Liosis, Sunita Ghosh, Tarek A. Bismar
Summary: ARPC1B is found to play a role in the invasion and metastasis of prostate cancer, and is associated with ERG and PTEN. High expression of ARPC1B is related to the aggressiveness and prognosis of PCa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Qiaoyi Sun, Li Ma, Jing Qiao, Xing Wang, Jianguo Li, Yuxi Wang, Ailing Tan, Zihui Ye, Yukang Wu, Jiajie Xi, Jiuhong Kang
Summary: The expression level of miR-181a-5p was found to be decreased in the hippocampal NSCs of aged mice, and exogenous overexpression of miR-181a-5p promoted NSC proliferation and improved learning and memory impairments caused by aging. The mechanistic study revealed that miR-181a-5p targeted phosphatase and tensin homolog (PTEN), a negative regulator of the AKT signaling pathway, and knockdown of PTEN rescued the impairment of NSC proliferation by low miR-181a-5p levels. Furthermore, overexpression of miR-181a-5p in the dentate gyrus increased NSC proliferation and ameliorated learning and memory impairments in aged mice.
Article
Biochemistry & Molecular Biology
Chen Xie, Pen-Jen Lin, Jijun Hao
Summary: PDE4D is highly expressed in chemo-resistant prostate cancer cells, and inhibiting PDE4D with Eggmanone effectively reduces invasion, proliferation, and induces cell death in these cells. Eggmanone also enhances docetaxel cytotoxicity and down-regulates CSC marker gene expression, attenuating sphere formation in chemo-resistant prostate cancer cells.
Article
Oncology
Eddie Luidy Imada, Diego Fernando Sanchez, Wikum Dinalankara, Thiago Vidotto, Ericka M. Ebot, Svitlana Tyekucheva, Gloria Regina Franco, Lorelei Ann Mucci, Massimo Loda, Edward Matthew Schaeffer, Tamara Lotan, Luigi Marchionni
Summary: In this study, a transcriptional signature of PTEN loss in prostate cancer was identified, showing activation of immune systems and cell-cycle genes. The study also discovered potential novel lncRNAs associated with PTEN loss and prostate cancer progression, expanding the understanding of the molecular landscape in PCa. The findings suggest that PTEN loss in prostate cancer leads to increased immune system activation, contrary to observations in other cancers, which could have implications for the development of biomarkers and therapy choices.
Article
Biochemistry & Molecular Biology
Tingting Feng, Ru Zhao, Hanwen Zhang, Feifei Sun, Jing Hu, Meng Wang, Mei Qi, Ling Liu, Lin Gao, Yabo Xiao, Junhui Zhen, Weiwen Chen, Lin Wang, Bo Han
Summary: This study reveals an inverse correlation between PTEN expression and unfolded protein response (UPR) signature score in prostate cancer. PTEN suppresses the activity of ATF6a by de-phosphorylating and inhibiting its nuclear translocation, while ATF6a promotes PTEN degradation through inducing CHIP expression. Inhibition of ATF6a in combination with AKT inhibitor shows promising anti-tumor effects. This study highlights ATF6a as a therapeutic target in PTEN dysfunctional prostate cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell Biology
Ako Yokoi, Marina Minami, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Yoshinori Hasegawa, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Youhei Harada, Naomi Fukagawa, Makoto Saegusa
Summary: This study found that PTEN overexpression in endometrial carcinoma is associated with various cellular and molecular changes, including epithelial-mesenchymal transition, cellular senescence, apoptosis, migration capability, and cancer stem cell-like properties. In clinical samples, the PTEN score was positively correlated with the expression of molecules related to morular lesions and negatively correlated with cell proliferation. Furthermore, the expression of ERα/EBP50 acted as a negative regulator of morular formation by interacting with PTEN and beta-catenin.
CELL COMMUNICATION AND SIGNALING
(2022)
