The Promise of Circulating Tumor DNA (ctDNA) in the Management of Early-Stage Colon Cancer: A Critical Review

Colorectal cancer statistics, 2020

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Latency and interval therapy affect the evolution in metastatic colorectal cancer

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Novel methylated DNA markers in plasma detect distant recurrence of colorectal cancer.

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Cross-sectional analysis of circulating tumor DNA in primary colorectal cancer at surgery and during post-surgery follow-up by liquid biopsy

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ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper

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Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions

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Clonal haematopoiesis: a source of biological noise in cell-free DNA analyses

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FOxTROT: an international randomised controlled trial in 1052 patients (pts) evaluating neoadjuvant chemotherapy (NAC) for colon cancer.

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A plasma-only integrated genomic and epigenomic circulating tumor DNA (ctDNA) assay to inform recurrence risk in colorectal cancer (CRC).

(2019) Aparna Raj Parikh et al.   JOURNAL OF CLINICAL ONCOLOGY

Prognostic Potential of Circulating Tumor DNA Measurement in Postoperative Surveillance of Nonmetastatic Colorectal Cancer

(2019) Yuxuan Wang et al.   JAMA Oncology

Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer

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LBA-006BEACON CRC: a randomized, 3-Arm, phase 3 study of encorafenib and cetuximab with or without binimetinib vs. choice of either irinotecan or FOLFIRI plus cetuximab in BRAF V600E–mutant metastatic colorectal cancer

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Clonal Hematopoiesis

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LBA30_PRAnalysis of circulating tumour DNA (ctDNA) from patients enrolled in the IDEA-FRANCE phase III trial: Prognostic and predictive value for adjuvant treatment duration

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Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer

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Early change in circulating tumor DNA as a potential predictor of response to chemotherapy in patients with metastatic colorectal cancer

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Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer

(2019) Jeanne Tie et al.   JAMA Oncology

Plasma vs. serum in circulating tumor DNA measurement: characterization by DNA fragment sizing and digital droplet polymerase chain reaction

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Detection of clonal hematopoiesis of indeterminate potential in clinical sequencing of solid tumor specimens

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New Insights from Studies of Clonal Hematopoiesis

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False positive plasma genotyping due to clonal hematopoiesis

(2018) Yuebi Hu et al.   CLINICAL CANCER RESEARCH

Association Between Intensity of Posttreatment Surveillance Testing and Detection of Recurrence in Patients With Colorectal Cancer

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Early stage NSCLC — challenges to implementing ctDNA-based screening and MRD detection

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Duration of Adjuvant Chemotherapy for Stage III Colon Cancer

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Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA

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Monitoring colorectal cancer following surgery using plasma circulating tumor DNA

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International pilot external quality assessment scheme for analysis and reporting of circulating tumour DNA

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Recurrence Risk After Up-to-Date Colon Cancer Staging, Surgery, and Pathology

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Serial circulating tumor DNA (ctDNA) analysis as a prognostic marker and a real-time indicator of adjuvant chemotherapy (CT) efficacy in stage III colon cancer (CC).

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Circulating Free Methylated Tumor DNA Markers for Sensitive Assessment of Tumor Burden and Early Response Monitoring in Patients Receiving Systemic Chemotherapy for Colorectal Cancer Liver Metastasis

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Application of Cell-free DNA Analysis to Cancer Treatment

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Enhanced detection of circulating tumor DNA by fragment size analysis

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Application of circulating tumor DNA in prospective clinical oncology trials - standardization of preanalytical conditions

(2017) Lisanne F. van Dessel et al.   Molecular Oncology

Direct detection of early-stage cancers using circulating tumor DNA

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Non-blood circulating tumor DNA detection in cancer

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Hazard rate of tumor recurrence over time in patients with colon cancer: implications for postoperative surveillance from three Japanese Foundation for Multidisciplinary Treatment of Cancer (JFMC) clinical trials

(2017) Hiromichi Maeda et al.   Journal of Cancer

Treatment monitoring in metastatic colorectal cancer patients by quantification and KRAS genotyping of circulating cell-free DNA

(2017) Andreas W. Berger et al.   PLoS One

Origins, structures, and functions of circulating DNA in oncology

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Should the Benefit of Adjuvant Chemotherapy in Colon Cancer Be Re-Evaluated?

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Integrated digital error suppression for improved detection of circulating tumor DNA

(2016) Aaron M Newman et al.   NATURE BIOTECHNOLOGY

From tumour heterogeneity to advances in precision treatment of colorectal cancer

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Identification of tissue-specific cell death using methylation patterns of circulating DNA

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Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

(2016) Jeanne Tie et al.   Science Translational Medicine

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

(2016) Andrew L. Young et al.   Nature Communications

Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer

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Toward understanding and exploiting tumor heterogeneity

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Risk of recurrence in patients with colon cancer stage II and III: A systematic review and meta-analysis of recent literature

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Metachronous metastases from colorectal cancer: a population-based study in North-East Netherlands

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Liquid Biopsies: Genotyping Circulating Tumor DNA

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An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

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Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

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Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

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Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

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High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

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Detection and quantification of rare mutations with massively parallel sequencing

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Improved Overall Survival With Oxaliplatin, Fluorouracil, and Leucovorin As Adjuvant Treatment in Stage II or III Colon Cancer in the MOSAIC Trial

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Circulating mutant DNA to assess tumor dynamics

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