The Treatment of Heterotopic Human Colon Xenograft Tumors in Mice with 5-Fluorouracil Attached to Magnetic Nanoparticles in Combination with Magnetic Hyperthermia Is More Efficient than Either Therapy Alone

Hyperthermia affects collagen fiber architecture and induces apoptosis in pancreatic and fibroblast tumor hetero-spheroids in vitro

(2020) Susann Piehler et al.   Nanomedicine-Nanotechnology Biology and Medicine

Magnetic Nanoparticles Behavior in Biological Solutions; The Impact of Clustering Tendency on Sedimentation Velocity and Cell Uptake

(2020) Mohammad Dabaghi et al.   Materials

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Colorectal cancer

(2019) Evelien Dekker et al.   LANCET

AMALTHEA: Prospective, Single-Arm Study of the Hellenic Cooperative Oncology Group (HeCOG) Evaluating Efficacy and Safety of First-Line FOLFIRI + Aflibercept for 6 Months Followed by Aflibercept Maintenance in Patients With Metastatic Colorectal Cancer

(2018) George Pentheroudakis et al.   Clinical Colorectal Cancer

Clinical significance of heat shock proteins in gastric cancer following hyperthermia stress: Indications for hyperthermic intraperitoneal chemoperfusion therapy

(2018) Yinuo Tu et al.   Oncology Letters

The influence of gut microbiota dysbiosis to the efficacy of 5-Fluorouracil treatment on colorectal cancer

(2018) Lu Yuan et al.   BIOMEDICINE & PHARMACOTHERAPY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mutant p53 as a guardian of the cancer cell

(2018) Fiamma Mantovani et al.   CELL DEATH AND DIFFERENTIATION

Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer

(2017) Robert Ludwig et al.   International Journal of Nanomedicine

Nanoparticle-based hyperthermia, a local treatment modulating the tumor extracellular matrix

(2017) Jelena Kolosnjaj-Tabi et al.   PHARMACOLOGICAL RESEARCH

Tumor Stiffening, a Key Determinant of Tumor Progression, is Reversed by Nanomaterial-Induced Photothermal Therapy

(2017) Iris Marangon et al.   Theranostics

Preparation of 5-fluorouracil-loaded chitosan nanoparticles and study of the sustained release in vitro and in vivo

(2017) Li Sun et al.   Asian Journal of Pharmaceutical Sciences

Inhibition of NF-κB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer

(2016) Balney Rajitha et al.   CANCER LETTERS

Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31)

(2016) Panida Lertkiatmongkol et al.   CURRENT OPINION IN HEMATOLOGY

Evaluation of the cytotoxic effects of hyperthermia and 5-fluorouracil-loaded magnetic nanoparticles on human colon cancer cell line HT-29

(2016) Samira Eynali et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Heterogeneous response of different tumor cell lines to methotrexate-coupled nanoparticles in presence of hyperthermia

(2016) Marcus Stapf et al.   International Journal of Nanomedicine

Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4

(2015) Alla Polotskaia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zerumbone induces mitochondria-mediated apoptosis via increased calcium, generation of reactive oxygen species and upregulation of soluble histone H2AX in K562 chronic myelogenous leukemia cells

(2015) Iyyappan Rajan et al.   TUMOR BIOLOGY

Gypenosides Synergistically Enhances the Anti-Tumor Effect of 5-Fluorouracil on Colorectal Cancer In Vitro and In Vivo: A Role for Oxidative Stress-Mediated DNA Damage and p53 Activation

(2015) Lulu Kong et al.   PLoS One

Heat-Generating Iron Oxide Nanocubes: Subtle “Destructurators” of the Tumoral Microenvironment

(2014) Jelena Kolosnjaj-Tabi et al.   ACS Nano

High Therapeutic Efficiency of Magnetic Hyperthermia in Xenograft Models Achieved with Moderate Temperature Dosages in the Tumor Area

(2014) Susanne Kossatz et al.   PHARMACEUTICAL RESEARCH

Structural properties of magnetic nanoparticles determine their heating behavior - an estimation of the in vivo heating potential

(2014) Robert Ludwig et al.   Nanoscale Research Letters

Cancer therapeutics: Targeting the apoptotic pathway

(2013) Khurum H. Khan et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

NF-?B addiction and resistance to 5-fluorouracil in a multi-stage colon carcinoma model

(2013) Maria I. Körber et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

In vivoapplications of magnetic nanoparticle hyperthermia

(2013) Ingrid Hilger   INTERNATIONAL JOURNAL OF HYPERTHERMIA

 v Integrins in Angiogenesis and Cancer

(2013) S. M. Weis et al.   Cold Spring Harbor Perspectives in Medicine

Synthesis of thermo-sensitive CS-g-PNIPAM/CMC complex nanoparticles for controlled release of 5-FU

(2012) Ting Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies

(2012) Berina Eppink et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

5-Fluorouracil Encapsulated Chitosan Nanoparticles for pH-Stimulated Drug Delivery: Evaluation of Controlled Release Kinetics

(2012) R. Seda Tığlı Aydın et al.   Journal of Nanomaterials

DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway

(2012) M A Kang et al.   Cell Death & Disease

pH-Triggered Drug-Releasing Magnetic Nanoparticles for Cancer Therapy Guided by Molecular Imaging by MRI

(2011) Eun-Kyung Lim et al.   ADVANCED MATERIALS

A multicenter phase II clinical study of oxaliplatin, folinic acid, and 5-fluorouracil combination chemotherapy as first-line treatment for advanced colorectal cancer: A Japanese experience

(2011) Hideo Baba et al.   SURGERY TODAY

Rosiglitazone enhances the radiosensitivity of p53-mutant HT-29 human colorectal cancer cells

(2010) Shu-Jun Chiu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-angiogenic effect of 5-Fluorouracil-based drugs against human colon cancer xenografts

(2008) Akio Ooyama et al.   CANCER LETTERS

DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae

(2008) Lori A. Rowe et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil

(2008) Takako Eguchi Nakajima et al.   INTERNATIONAL JOURNAL OF CANCER

Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis

(2008) Ying Liu et al.   Molecular Cancer