Zerumbone induces mitochondria-mediated apoptosis via increased calcium, generation of reactive oxygen species and upregulation of soluble histone H2AX in K562 chronic myelogenous leukemia cells

BCR-ABL1 kinase domain mutations may persist at very low levels for many years and lead to subsequent TKI resistance

(2013) W T Parker et al.   BRITISH JOURNAL OF CANCER

Calpain and Reactive Oxygen Species Targets Bax for Mitochondrial Permeabilisation and Caspase Activation in Zerumbone Induced Apoptosis

(2013) Praveen K. Sobhan et al.   PLoS One

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

(2012) Remya Prasannan et al.   BIOCHEMICAL PHARMACOLOGY

An exopolysaccharide from Trichoderma pseudokoningii and its apoptotic activity on human leukemia K562 cells

(2012) Taotao Huang et al.   CARBOHYDRATE POLYMERS

Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway

(2012) Songyan Zhang et al.   Evidence-based Complementary and Alternative Medicine

Interplay of reactive oxygen species, intracellular Ca2+and mitochondrial homeostasis in the apoptosis of prostate cancer cells by deoxypodophyllotoxin

(2012) Kwang-Youn Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cytotoxic effect and apoptotic mechanism of tanshinone A, a novel tanshinone derivative, on human erythroleukemic K562 cells

(2011) Xia Zhen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes

(2010) Adel S. Al-Zubairi et al.   TOXICOLOGY IN VITRO

Proapoptotic Activity of Bortezomib in Gastrointestinal Stromal Tumor Cells

(2009) S. Bauer et al.   CANCER RESEARCH

Impact of Natural Products on Developing New Anti-Cancer Agents†

(2009) Gordon M. Cragg et al.   CHEMICAL REVIEWS

MZ3 can induce G2/M-phase arrest and apoptosis in human leukemia cells

(2008) Liang Fang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis

(2008) Ying Liu et al.   Molecular Cancer

Genotoxicity of thimerosal in cultured human lymphocytes with and without metabolic activation sister chromatid exchange analysis proliferation index and mitotic index

(2008) Dilek Eke et al.   TOXICOLOGY IN VITRO