Article
Gastroenterology & Hepatology
Matthew J. McConnell, Nao Kawaguchi, Reiichiro Kondo, Aurelio Sonzogni, Lisa Licini, Clarissa Valle, Pietro A. Bonaffini, Sandro Sironi, Maria Grazia Alessio, Giulia Previtali, Michela Seghezzi, Xuchen Zhang, Alfred Lee, Alexander B. Pine, Hyung J. Chun, Xinbo Zhang, Carlos Fernandez-Hernando, Hua Qing, Andrew Wang, Christina Price, Zhaoli Sun, Teruo Utsumi, John Hwa, Mario Strazzabosco, Yasuko Iwakiri
Summary: Analysis of COVID-19 patients suggests that IL-6 trans-signaling may cause hepatic endotheliopathy and blood clot formation, leading to liver injury.
JOURNAL OF HEPATOLOGY
(2021)
Review
Hematology
Mehran Bahraini, Akbar Dorgalaleh
Summary: The main pathology of COVID-19 involves infection of pulmonary tract cells, leading to an inflammatory response and coagulation disorders that can result in thrombotic events. Understanding the pathophysiological mechanisms behind these events is crucial for developing more effective therapeutic strategies.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Medicine, General & Internal
Andrea Boccatonda, Damiano D'Ardes, Ilaria Rossi, Alice Grignaschi, Antonella Lanotte, Francesco Cipollone, Maria Teresa Guagnano, Fabrizio Giostra
Summary: The study aimed to investigate platelet count values in COVID-19 patients and found a correlation between platelet count and respiratory alteration parameters and clinical outcome. The results suggest that SARS-CoV-2 infection may induce thrombocytopenia, and platelet count reduction could be associated with clinical prognosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Junyi Zhao, Xiafan Xu, Yifei Gao, Yijing Yu, Conglei Li
Summary: This review discusses the potential mechanisms underlying the increased thrombotic events and altered platelet count and activity in COVID-19. The researchers propose several potential antiviral strategies that platelets might undertake and discuss platelet-targeted therapeutic strategies in controlling COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Cristian-Mihail Niculae, Adriana Hristea, Ruxandra Moroti
Summary: COVID-19 is often associated with pulmonary thrombotic events, especially in hospitalized patients, due to the proinflammatory state and disbalance in hemostasis caused by severe SARS-CoV-2 infection. Immune cells, cytokines, chemokines, and the complement system play key roles in immunothrombosis, damaging endothelial cells and inducing proinflammatory and procoagulant positive feedback loops. COVID-19-associated cytokine storm, platelets, red blood cells, and coagulation pathways contribute to the inflammation-endotheliopathy-thrombosis axis. The hypothesis of immunothrombosis is supported by imaging data showing peripheral blood clots associated with inflammatory lesions and the high incidence of thrombotic events despite routine thromboprophylaxis for venous thromboembolism.
Article
Cardiac & Cardiovascular Systems
Manuela De Michele, Joshua Kahan, Irene Berto, Oscar G. Schiavo, Marta Iacobucci, Danilo Toni, Alexander E. Merkler
Summary: The risk of stroke and cerebrovascular disease complicating SARS-CoV-2 infection has been extensively reported. The rapid development and mass vaccination of DNA and mRNA vaccines against SARS-CoV-2 have led to rare but catastrophic cases of thrombosis. This review provides an overview of stroke and cerebrovascular complications of SARS-CoV-2 infection, as well as vaccinations, with a focus on vaccine-induced immune thrombotic thrombocytopenia. A therapeutic protocol is proposed based on available data.
CIRCULATION RESEARCH
(2022)
Review
Immunology
Sonia Aparecida de Andrade, Daniel Alexandre de Souza, Amarylis Lins Torres, Cristiane Ferreira Graca de Lima, Matteo Celano Ebram, Rosa Maria Gaudioso Celano, Mirta Schattner, Ana Marisa Chudzinski-Tavassi
Summary: This review discusses the hemostatic changes that occur in SARS-CoV-2 infection, with a focus on endothelial dysfunction, kallikrein-kinins, renin-angiotensin, and the coagulation/fibrinolysis systems as underlying factors of COVID-19. Understanding these mechanisms is crucial for the development of new therapeutic approaches to attenuate the severity of infection and reduce mortality.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anthony Sciaudone, Heather Corkrey, Fiachra Humphries, Milka Koupenova
Summary: COVID-19 is characterized by dysregulated thrombosis and coagulation, which can increase mortality. Platelets have been found to have direct interaction with the SARS-CoV-2 virus, alerting immune cells and contributing to thrombosis and coagulation. This review discusses the immune, prothrombotic, and procoagulant characteristics of platelets in COVID-19 patients, as well as the interaction of platelets with the virus and its effects on programmed cell death and extracellular vesicle release. Murine models and mouse adaptable strains are also discussed to understand COVID-19-mediated thrombosis and coagulation.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shinya Yamada, Hidesaku Asakura
Summary: COVID-19, caused by SARS-CoV-2, often leads to thrombosis. Attention should be paid to both coagulation activation and fibrinolytic activation in the treatment of COVID-19. Vaccination with SARS-CoV-2 vaccines may result in various thrombotic complications. Vaccine-induced immune thrombotic thrombocytopenia (VITT) is characterized by the presence of anti-platelet factor 4 antibodies and thrombosis in unusual locations. Evaluation of coagulation activation and fibrinolytic activation is important for the treatment of VITT, with adjustments made accordingly for improved outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Vahid Reza Ostovan, Razieh Foroughi, Mahtab Rostami, Mostafa Almasi-Dooghaee, Manouchehr Esmaili, Ali Akbar Bidaki, Zahra Behzadi, Farzane Farzadfard, Hoda Marbooti, Abbas Rahimi-Jaberi, Maryam Poursadeghfard, Nima Fadakar, Mahnaz Bayat, Maryam Owjfard, Mohammad Saied Salehi, Seyedeh Shaghayegh Zafarmand, Farzad Mardi, Anahid Safari, Shima Shahjouei, Ashkan Mowla, Mahmoud Reza Azarpazhooh, Ramin Zand, Etrat Hooshmandi, Afshin Borhani-Haghighi
Summary: This study reported six cases of confirmed CVST and SARS-CoV-2 infection, with four patients presenting no respiratory symptoms. Patients with SARS-COV-2 associated CVST were older, with lower female/male ratio and higher mortality rate compared to CVST not associated with COVID-19. Despite receiving treatment, four patients died.
JOURNAL OF NEUROLOGY
(2021)
Review
Medicine, Research & Experimental
Robin M. Cunningham, Kyle L. Johnson Moore, Jacen S. Moore
Summary: The COVID-19 pandemic caused by SARS-CoV-2 is spreading rapidly, with symptoms including runny nose, headache, cough, and fever. Severe cases can lead to respiratory failure and multi-organ failure. Clinical evidence has shown that COVID-19-associated coagulopathy (CAC) is distinct from disseminated intravascular coagulation (DIC). This review focuses on laboratory results for diagnosing CAC, mechanisms of CAC induction, and novel therapeutic regimens.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Juliette Servante, Gill Swallow, Jim G. Thornton, Bethan Myers, Sandhya Munireddy, A. Kinga Malinowski, Maha Othman, Wentao Li, Keelin O'Donoghue, Kate F. Walker
Summary: The study suggests that pregnancies affected by COVID-19 are at increased risk of coagulopathy and thromboembolism. Detection of coagulopathy may help identify women at risk of deterioration.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Biology
Eric Kowarz, Lea Krutzke, Marius Kulp, Patrick Streb, Patrizia Larghero, Jennifer Reis, Silvia Bracharz, Tatjana Engler, Stefan Kochanek, Rolf Marschalek
Summary: A global vaccination campaign is underway to immunize billions of people against the COVID-19 pandemic. However, rare cases of severe side effects, such as cerebral venous sinus thrombosis (CVST), have been reported after vaccination with adenoviral vector-based vaccines. These events have not been observed with mRNA-based vaccines. Scientists have proposed a mechanism called vaccine-induced immune thrombotic thrombocytopenia (VITT) and discovered that DNA-encoded Spike protein can be spliced in a way that leads to the secretion of potentially harmful Spike variants. Avoiding such splicing events is important for the safety of future vaccines.
Article
Critical Care Medicine
Julie Helms, Francois Severac, Hamid Merdji, Maleka Schenck, Raphael Clere-Jehl, Mathieu Baldacini, Mickael Ohana, Lelia Grunebaum, Vincent Castelain, Eduardo Angles-Cano, Laurent Sattler, Ferhat Meziani
Summary: Using therapeutic anticoagulation in COVID-19 patients may decrease thrombotic complications without increasing bleeding risk, potentially improving survival rates.
ANNALS OF INTENSIVE CARE
(2021)
Article
Medical Laboratory Technology
Elena Campello, Cristiana Bulato, Luca Spiezia, Annalisa Boscolo, Francesco Poletto, Marco Cola, Sabrina Gavasso, Chiara Simion, Claudia Maria Radu, Annamaria Cattelan, Ivo Tiberio, Roberto Vettor, Paolo Navalesi, Paolo Simioni
Summary: COVID-19 patients showed increased thrombin generation at diagnosis. Standard thromboprophylaxis reduced thrombin generation to levels of healthy controls. Intermediate sub-therapeutic thromboprophylaxis more effectively inhibited thrombin generation by decreasing ETP with TM.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Sylwia Pietrasik, Natalia Cichon, Michal Bijak, Leslaw Gorniak, Joanna Saluk-Bijak
Summary: Neuroplasticity plays a crucial role in the treatment of central nervous system (CNS) disorders, and marine carotenoids, abundant in the aquatic environment, have antioxidant and neuroprotective effects that can promote neuronal recovery and enhancement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Paulina Wigner, Michal Bijak, Joanna Saluk-Bijak
Summary: Nephrolithiasis ranks third in prevalence among urological diseases, with the increasing incidence likely attributed to unhealthy dietary and lifestyle changes in developed countries. Oxalate urolithiasis, making up about 80% of cases, poses the highest risk of recurrence. Frequent relapses lead to severe complications and high treatment costs.
Article
Biochemistry & Molecular Biology
Edyta Janik-Karpinska, Michal Ceremuga, Magdalena Wieckowska, Monika Szyposzynska, Marcin Niemcewicz, Ewelina Synowiec, Tomasz Sliwinski, Michal Bijak
Summary: T-2 toxin, produced by various Fusarium species, can infect crops such as wheat, barley, and corn. This in vitro study reveals that T-2 toxin induces necrosis in human skin fibroblast cells, providing new insights into its toxic mechanism on the skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Angela Dziedzic, Rafal Szelenberger, Michal Kacprzak, Piotr Czarny, Ewelina Synowiec, Joanna Saluk-Bijak, Tomasz Sliwinski, Marzenna Zielinska, Michal Bijak
Summary: The pathophysiology of atherosclerosis and acute coronary syndrome (ACS) is related to interactions between immune cells, endothelium, and blood platelets. Excessive immune activation and ACS incidence are linked, and augmented expression of pro-inflammatory genes from peripheral blood cells may be a crucial genetic factor in ACS pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Paulina Wigner, Michal Bijak, Joanna Saluk-Bijak
Summary: Bladder cancer is the most common tumor of the urinary system, and despite anticancer therapies, it has a high recurrence risk. In addition to smoking, occupational exposure, and genetic factors, diet quality may also influence the development of bladder cancer. Adequate consumption of fruits such as pomegranates and cranberries can reduce the risk of bladder cancer.
Article
Biochemistry & Molecular Biology
Radoslaw Grebowski, Joanna Saluk, Michal Bijak, Janusz Szemraj, Paulina Wigner
Summary: Bladder cancer is the 10th most common form of cancer globally, and chronic inflammation may play a role in its development and progression. This study aimed to investigate the association between selected single nucleotide polymorphisms (SNPs) in IL-6 and IL-8 genes and bladder cancer development, as well as the impact of bladder cancer on the expression and methylation of IL-6 and IL-8 promoters in PBMCs. The study found no association between the studied SNPs and bladder cancer occurrence. However, bladder cancer patients had decreased IL-6 and IL-8 mRNA expression levels and higher methylation status of the IL-6 promoter compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Edyta Janik-Karpinska, Michal Ceremuga, Marcin Niemcewicz, Ewelina Synowiec, Tomasz Sliwinski, Michal Bijak
Summary: T-2 toxin has adverse effects on Hs68 cell mitochondria, causing mitochondrial dysfunction and mtDNA damage, which can result in cell death.
Article
Biochemistry & Molecular Biology
Edyta Janik-Karpinska, Michal Ceremuga, Marcin Niemcewicz, Ewelina Synowiec, Tomasz Sliwinski, Maksymilian Stela, Michal Bijak
Summary: This study demonstrates that T-2 toxin has genotoxic effects on human skin fibroblast cells, potentially causing damage to nuclear DNA and leading to changes in gene expression related to inflammation and repair processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Magdalena Wieckowska, Rafal Szelenberger, Marcin Niemcewicz, Piotr Harmata, Tomasz Poplawski, Michal Bijak
Summary: Ochratoxin A (OTA) is a highly toxic mycotoxin produced by fungi, which commonly contaminates food and beverages, posing risks to animal and human health. The exact mechanism of OTA's toxicity and effective preventive measures are still not well understood, highlighting the need for further research.
Review
Health Care Sciences & Services
Edyta Janik-Karpinska, Rachele Brancaleoni, Marcin Niemcewicz, Wiktor Wojtas, Maurizio Foco, Marcin Podogrocki, Michal Bijak
Summary: Healthcare waste is mainly generated in healthcare facilities, with 15% of it being hazardous. It contains potentially harmful microorganisms that can pose a threat to human health and the environment if not properly treated. Proper waste management measures should be taken to reduce the negative impact.
Article
Biochemistry & Molecular Biology
Piotr Czarny, Sylwia Ziolkowska, Lukasz Kolodziej, Cezary Watala, Paulina Wigner-Jeziorska, Katarzyna Blizniewska-Kowalska, Katarzyna Wachowska, Malgorzata Galecka, Ewelina Synowiec, Piotr Galecki, Michal Bijak, Janusz Szemraj, Tomasz Sliwinski
Summary: This study explores the impact of SNPs in genes encoding enzymes involved in mtDNA replication, repair, or degradation on the occurrence, onset, severity, and treatment of MDD. The findings suggest that mtDNA damage and impairment in its metabolism play a crucial role in the development and treatment of depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Klaudia Marek, Natalia Cichon, Joanna Saluk-Bijak, Michal Bijak, Elzbieta Miller
Summary: Hypovitaminosis D is a serious public health problem, and maintaining normal serum vitamin D levels can improve cardiovascular health and reduce stroke risk. Vitamin D also influences brain development, immune modulation, and brain neuroplasticity. Further research is needed to explore the effects of vitamin D supplementation on stroke survivors' rehabilitation outcomes and prevention.