Review
Pharmacology & Pharmacy
Yuhei Nishimura, Kenji Kurosawa
Summary: This mini-review discusses the interaction between genetic and environmental factors in developmental disorders (DDs) using genome-wide and candidate gene-based approaches. It focuses on zebrafish and mouse models and introduces novel methods for analyzing G x E associated with DDs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Paul T. Williams
Summary: Heritability of IL-6 concentrations is quantile-dependent, showing larger genetic effects in diseases and conditions that elevate IL-6 concentrations compared to unaffected controls.
Article
Geriatrics & Gerontology
Annabel P. P. Matison, Anbupalam Thalamuthu, Victoria M. M. Flood, Julian N. N. Trollor, Vibeke S. S. Catts, Margaret J. J. Wright, David Ames, Henry Brodaty, Perminder S. S. Sachdev, Simone Reppermund, Karen A. A. Mather
Summary: Previous research suggests that a higher intake of fruits and vegetables may protect against depression in older adults. This study aims to estimate the genetic and environmental influences on fruit and vegetable consumption in older adults, and explore the potential shared genetic influences on consumption and depression.
Article
Biochemistry & Molecular Biology
I-Hang Chung, Yu-Shu Huang, Ting-Hsuan Fang, Chia-Hsiang Chen
Summary: Schizophrenia and affective disorder are complex mental disorders with high heritability. Rare variants contribute to the genetic liability of these two disorders. Whole genome sequencing analysis identified multiple rare inherited variants in two families, providing evidence that these variants may contribute to the heritability of psychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Yuanyuan Gui, Xiaocheng Zhou, Zixin Wang, Yiliang Zhang, Zhaobin Wang, Geyu Zhou, Yize Zhao, Manhua Liu, Hui Lu, Hongyu Zhao
Summary: This study examined the associations between the predicted polygenic risk scores of six psychiatric disorders and cognitive functions, behavior, and brain imaging traits using publicly available genome-wide association studies and individual-level data from the Adolescent Brain Cognitive Development study and the UK Biobank study. Significant heterogeneity was found in genetic associations between cognitive traits and psychiatric disorders, as well as behavior and brain imaging, between sexes.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Genetics & Heredity
Marah H. Wahbeh, Dimitrios Avramopoulos
Summary: Schizophrenia is a devastating mental illness with a strong genetic component, but non-genetic factors also play a role. Research shows that interactions between genes and the environment can increase the risk of developing psychosis, which is crucial for understanding the pathogenesis of the disease.
Article
Clinical Neurology
Hongyan Lin, Mengdi Jin, Qian Liu, Yue Du, Jingzhu Fu, Changqing Sun, Fei Ma, Wen Li, Huan Liu, Xumei Zhang, Yun Zhu, Yongjie Chen, Zhuoyu Sun, Guangshun Wang, Guowei Huang, Jing Yan
Summary: The study found that the prevalence of geriatric depression in rural Tianjin was 12.2% (9.5% in men and 14.5% in women). Factors such as gender, education, household income, employment, living alone, social activities, physical exercise, and chronic diseases were associated with depression. Additionally, sleep duration was also related to depression scores.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Abdus Samad Ansari, Jelle Vehof, Christopher J. Hammond, Fion D. Bremner, Katie M. Williams
Summary: Genetic factors play a key role in determining resting pupil size and reactivity, with heritability estimated at 86% for pupil size and various pupillary reactions. Age was found to be associated with pupil size and light reaction, while iris color, intraocular pressure, and refractive error showed no significant association with pupil characteristics in this study.
FRONTIERS IN NEUROLOGY
(2021)
Editorial Material
Nutrition & Dietetics
M. Catherine DeSoto
Summary: The important role of nutrition in neural functioning and mental health is still under recognized. This Special Issue aims to provide authoritative information on this topic. The editorial suggests that the combination of social isolation, lack of exercise, and remaining indoors during 2020 may change Gene x Environment interactions for anxiety and depression. The recent environmental changes may exacerbate the problem of nutritional deficiencies. Key research, specific genetic examples, and theoretical implications regarding natural selection are discussed.
Review
Peripheral Vascular Disease
Jaana A. Hartiala, James R. Hilser, Subarna Biswas, Aldons J. Lusis, Hooman Allayee
Summary: Recent research has mainly focused on gene-environment interactions for cardiovascular disease risk, particularly in relation to smoking and coronary artery disease. Limited evidence exists for interactions between other exposures such as physical activity, air pollution, diet, and sex with CVD outcomes. Establishing large consortia and population-based cohorts, along with new computational tools and mouse genetics platforms, may help overcome limitations in human GxE interaction studies and uncover additional association signals for CVD-related traits.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Review
Medicine, General & Internal
Jennifer M. P. Woo, Christine G. Parks, Soren Jacobsen, Karen H. Costenbader, Sasha Bernatsky
Summary: Systemic lupus erythematosus (SLE) is a complex chronic autoimmune disease caused by both genetic and environmental factors. Genetic risk factors account for only one-third of the observed heritability, with the remaining risk attributed to environmental exposures and gene-environment interactions. Occupational exposure to crystalline silica, current smoking, and exogenous estrogens are positively associated with SLE risk. Other factors like lifestyle behaviors, UV radiation, air pollution, solvents, pesticides, vaccines and medications, and infections may also contribute to SLE risk. Alcohol use may be associated with decreased risk. Gene-environment interactions involving IL-10, ESR1, IL-33, ITGAM, and NAT2, along with smoking, UV exposure, and alcohol, have been found to influence SLE risk. Understanding these risk factors and their interactions can help in understanding SLE pathogenesis and developing preventive interventions.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Forestry
Bruno Marchetti Souza, Ananda Virginia de Aguiar, Heloise Milena Dambrat, Simone Cristina Galucha, Evandro Vagner Tambarussi, Mayte Sampaio Cesario da Silva Sestrem, Dayane Samistraro Tomigian, Miguel Luiz Menezes Freitas, Ivan Venson, Diego Torres-Dini, Eduardo Luiz Longui
Summary: This study investigated the effects of previous land use on the adaptability, stability, and productivity of loblolly pine progenies in southern Brazil, aiming to produce a second-generation clonal seed orchard. Genetic parameters and genetic gains analysis revealed the importance of considering previous land use in the selection of genotypes for the formation of loblolly pine clonal seed orchards.
FOREST ECOLOGY AND MANAGEMENT
(2022)
Article
Psychology, Developmental
Karmel W. Choi, Marina Wilson, Tian Ge, Aaron Kandola, Chirag J. Patel, S. Hong Lee, Jordan W. Smoller
Summary: An integrative analysis of genomic and exposomic data in relation to internalizing and externalizing symptoms in the Adolescent Brain and Cognitive Development (ABCD) Study cohort was conducted. The results showed that both genetic and environmental factors play a role in youth mental health, with different domains of environmental exposures impacting internalizing and externalizing symptoms differently. The variance explained by genome-by-exposome (G x E) contributions was larger for externalizing symptoms than internalizing symptoms.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Psychiatry
Hanxin Zhang, Atif Khan, Steven A. Kushner, Andrey Rzhetsky
Summary: Schizophrenia is a leading cause of disability worldwide, and its etiology involves genetic and environmental factors. This study utilized unique data sources and mathematical models to estimate the contributions of genetic and environmental factors to schizophrenia risk, finding that environmental factors are an important source of explanatory variance.
Article
Neurosciences
Fan Luo, Zimo Zhu, Yang Du, Lei Chen, Yong Cheng
Summary: Postpartum depression is a serious mood disorder that occurs after childbirth and can have lifelong consequences for women and their families. It is influenced by various risk factors, including environmental and genetic factors. Gene-environment interactions play a role in postpartum depression, as evidenced by studies on genes related to neurotransmitters, the HPA axis, and the kynurenine pathway. However, the conclusions regarding these risk factors, especially genetic factors, are not consistent, and further research is needed to understand the heritability and susceptibility of postpartum depression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tongtong Ge, Zhuo Zhang, Jiayin Lv, Yunong Song, Jie Fan, Wei Liu, Xuefeng Wang, F. Scott Hall, Bingjin Li, Ranji Cui
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2017)
Article
Cell Biology
Ranji Cui, Jie Fan, Tongtong Ge, Linda Tang, Bingjin Li
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Neurosciences
Bingjin Li, Tongtong Ge, Ranji Cui
MOLECULAR NEUROBIOLOGY
(2018)
Review
Neurosciences
Xin Zhang, Tong Tong Ge, Guanghao Yin, Ranji Cui, Guoqing Zhao, Wei Yang
FRONTIERS IN NEUROSCIENCE
(2018)
Review
Cell Biology
Tongtong Ge, Jie Fan, Wei Yang, Ranji Cui, Bingjin Li
CELL DEATH & DISEASE
(2018)
Review
Pharmacology & Pharmacy
Ziqian Cheng, Ranji Cui, Tongtong Ge, Wei Yang, Bingjin Li
PHARMACOLOGICAL RESEARCH
(2020)
Review
Cell Biology
Fan Zhen Peng, Jie Fan, Tong Tong Ge, Qian Qian Liu, Bing Jin Li
CELL PROLIFERATION
(2020)
Article
Cell Biology
Tong Tong Ge, Xiao Xiao Yao, Feng Lian Zhao, Xiao Han Zou, Wei Yang, Ran Ji Cui, Bing jin Li
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Review
Pharmacology & Pharmacy
Tongtong Ge, Xiaoxiao Yao, Haisheng Zhao, Wei Yang, Xiaohan Zou, Fanzhen Peng, Bingjin Li, Ranji Cui
Summary: Increasing evidence suggests that dysbiosis of gut microbiota may be involved in the physiological mechanisms of neuropsychiatric disorders, but the exact pathways are still unclear. The complex crosstalk between neuroendocrine and immunological regulation may underlie the mechanisms by which gut microbiota are associated with neuropsychiatric disorders.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Immunology
Yicun Wang, Jiyao Sheng, Jin Chai, Cuilin Zhu, Xin Li, Wei Yang, Ranji Cui, Tongtong Ge
Summary: Glioma is a life-threatening malignant tumor with challenges in traditional treatments and drug delivery. Crossing the blood-brain barrier poses difficulties for drug vectors, but phage-based drugs offer advantages such as thermodynamic stability, biocompatibility, and low toxicity. Tumor-targeting peptides from phage library and phages displaying targeting peptides are ideal drug delivery agents for personalized treatment of glioma.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Haisheng Zhao, Xijing Mao, Cuilin Zhu, Xiaohan Zou, Fanzhen Peng, Wei Yang, Bingjin Li, Guangquan Li, Tongtong Ge, Ranji Cui
Summary: Autism spectrum disorder (ASD) is a series of neurodevelopmental diseases characterized by social communication deficits and repetitive behaviors. The dysregulation of GABAergic synaptic transmission is implicated in the pathogenesis of ASD, although the specific molecular mechanism is still unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Bingjin Li, Wei Yang, Tongtong Ge, Yao Wang, Ranji Cui
Summary: This article discusses the candidate mechanisms by which stress can lead to dysregulated microglia, which in turn contribute to the pathogenesis of depressive disorders. It suggests that changes in microglial function can strongly influence neuronal network activity through dysregulated cytokine secretion and increased release of neurotoxic metabolites, thereby contributing to pathological outcomes in response to stress.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Ziqian Cheng, Chenglan Kang, Songtian Che, Jingyun Su, Qihan Sun, Tongtong Ge, Yi Guo, Jiayin Lv, Zhihui Sun, Wei Yang, Bingjin Li, Xin Li, Ranji Cui
Summary: Berberine, a natural alkaloid compound, has been studied for its effects on neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Current evidence shows that it can inhibit neuroinflammation, oxidative stress, and endoplasmic reticulum stress, reducing neuron damage and apoptosis. Further research is needed to fully understand the specific mechanisms involved.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wen-Qian Zhu, Hui-Ying Wu, Zhi-Hui Sun, Yi Guo, Tong-Tong Ge, Bing-Jin Li, Xin Li, Ran-Ji Cui
Summary: Depression is a widespread and overlooked mood disorder, and natural Chinese medicine berberine has shown promising antidepressant effects. However, further research is needed to understand its efficacy and mechanism in treating depression.
FRONTIERS IN PHARMACOLOGY
(2022)
