Article
Medicine, General & Internal
Guifeng Zhang, Zhenhua Liu, Jiangming Zhong, Li Lin
Summary: The study revealed that circRNA ACAP2 contributes to the progression and radioresistance of colorectal cancer by promoting cell proliferation, migration, invasion, and inhibiting apoptosis. This effect is partly mediated through targeting the miR-143-3p/FZD4 axis and modulating the Wnt/β-catenin signaling pathway in CRC cells.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Wei Sun, Dao Wang, Yukun Zu, Yu Deng
Summary: The overexpression of lncRNA CASC7 in esophageal cancer is associated with tumor proliferation and poor prognosis, and it affects aerobic glycolysis by regulating the miR-143-3p/HK2 axis.
CELL DEATH DISCOVERY
(2022)
Article
Pathology
Xiaoqian Tuo, Yuanyuan Zhou, Xiling Yang, Sijia Ma, Dan Liu, Xiaoling Zhang, Huilian Hou, Ruiqi Wang, Xu Li, Le Zhao
Summary: This study identified GPNMB as a new target of miR-532-3p in ovarian cancer and investigated the functional mechanism of the miRNA by targeting the GPNMB/HIF-1 alpha/HK2 pathway. The study found that miR-532-3p inhibited the proliferation, migration, and invasion of ovarian cancer cells by suppressing aerobic glycolysis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Medicine, Research & Experimental
Keqin Zhou, Yongbao Wei, Xurui Li, Xin Yang
Summary: The study found that miR-223-3p is significantly upregulated in clinically collected urine samples and PCa cells with low radiosensitivity. Enhancing miR-223-3p further reduces radiosensitivity, while inhibiting miR-223-3p improves radiosensitivity of PC3 and LNCaP cells. miR-223-3p regulates radiosensitivity by enhancing cell glycolysis.
Article
Genetics & Heredity
Junhyung Kim, Min Woo Park, Young Joon Park, Ju Won Ahn, Jeong Min Sim, Suwan Kim, Jinhyung Heo, Ji Hun Jeong, Mihye Lee, Jaejoon Lim, Jong-Seok Moon
Summary: miR-542-3p plays a role in the HK2-mediated high glycolytic phenotype in human glioma cells, and the elevated levels of miR-542-3p and HK2 in high-grade glioma patients are associated with poor prognosis.
Article
Biochemistry & Molecular Biology
Ling Wang, Wei Wang, Yongcong Cai, Yuqiu Zhou, Jian Jiang, Yudong Ning, Chunyan Shui, Ronghao Sun, Yi Wang, Chao Li
Summary: A study has found that circ-NUP214, a circular RNA, is significantly upregulated in papillary thyroid carcinoma (PTC). By regulating the miR-15a-5p/HK2 axis, circ-NUP214 promotes PTC tumorigenesis. This finding provides a potential therapeutic target for PTC treatment.
BIOCHEMICAL GENETICS
(2022)
Article
Oncology
Jing Li, Yinmou Li, Hong Cheng
Summary: This study indicates that the silencing of circ-RPPH1 can suppress the malignant phenotypes and glycolysis of breast cancer cells through the miR-328-3p/HMGA2 axis, thereby impeding the progression of breast cancer.
CLINICAL BREAST CANCER
(2022)
Article
Cell Biology
Shaoxia Liu, Ningning Yang, Xu Jiang, Jian Wang, Junqiang Dong, Yonghua Gao
Summary: The research revealed that circZNF609 functions as an oncogenic circRNA, promoting lung cancer cell proliferation and migration by sequestering miR-142-3p, through mechanisms involving FUS RNA-binding protein and G protein subunit beta 2.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Zeyu Xing, Xin Wang, Jiaqi Liu, Menglu Zhang, Kexin Feng, Xiang Wang
Summary: The study found that circ_0069094 was upregulated in BC, associated with poor prognosis. Silencing circ_0069094 induced apoptosis, reduced proliferation, and glycolysis, while overexpression had opposite effects. Circ_0069094 was verified to regulate HK2 expression by sponging miR-591. These results suggest that circ_0069094 might serve as a prognostic biomarker and therapeutic target for BC.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Zhihuang Zhao, Gang Li, Yonggang Han, Yabin Li, Zhisheng Ji, Rui Guo, Xiaohong Yu
Summary: The circular RNA ZNF609 plays a critical role in regulating glioma by affecting cell growth, invasion, apoptosis, and glycolysis. ZNF609 modulates cell survival and glycolysis by targeting the miR-378b/SLC2A1 axis in glioma cells. ZNF609 and miR-378b may serve as potential therapeutic targets in treating glioma.
Article
Cell Biology
Ruoqin Wang, Jiayu Wang, Yanjun Chen, Yuqi Chen, Qinhua Xi, Linqing Sun, Xueguang Zhang, Guangbo Zhang, Xianglin Ding, Tongguo Shi, Weichang Chen
Summary: This study found that circLDLR is highly expressed in colorectal cancer and is closely associated with malignant progression and poor prognosis. circLDLR promotes growth and metastasis of CRC cells and is involved in the malignant development of CRC by modulating cholesterol levels. This study provides evidence for circLDLR as a potential biomarker and therapeutic target in CRC.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Xinkui Xiong, Lei Zhang, Bao Zang, Dafu Xu, Chen Chen, Gaochao Dong, Wenjie Xia, Yanhu Wu
Summary: Based on the classification of lung adenocarcinoma (LUAD) into five pathological subtypes, the study identified the lncRNA FAM83A-AS1 as a potential regulator of LUAD histologic patterns. Pan-cancer analysis showed a positive correlation between FAM83A-AS1 and high tumor mutational burden. In vitro assays demonstrated that FAM83A-AS1 promoted cell migration, invasion, and growth of LUAD cancer cells by regulating miR-202-3p and hexokinase II (HK2) expression.
Article
Genetics & Heredity
Qiang Yi, Junfeng Wei, Yangzhou Li
Summary: This study investigated the expressions of miR-103a-3p and TRIM66 in prostate cancer cells and their effects on DTX resistance and glycolysis. The results showed that miR-103a-3p was downregulated and TRIM66 was upregulated in PCa cells. Upregulation of miR-103a-3p and interference with TRIM66 inhibited the proliferation, metastasis, and glycolysis of DTX-resistant cells.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Yu Liu, Wentao Tang, Li Ren, Tianyu Liu, Meng Yang, Ye Wei, Yijiao Chen, Meiling Ji, Guosong Chen, Wenju Chang, Jianmin Xu
Summary: miR-500a-3p is downregulated in CRC and inhibits cancer cell proliferation and glycolysis by targeting CDK6.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Jian Chen, Runjie Wang, Enci Lu, Shan'ai Song, Yingwei Zhu
Summary: This study discovered that LINC00630 is upregulated in colon carcinoma tissues and cells, and its knockout inhibits proliferation and glycolysis while promoting apoptosis. It was also found that LINC00630 functions as a sponge for miR-409-3p and regulates cell growth, glycolysis, and apoptosis by targeting the miR-409-3p/HK2 axis. These findings provide insights into the progression of colon carcinoma and present LINC00630 as a potential therapeutic target.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)