The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma

Lactobacillus fermentum CECT5716 supplementation in rats during pregnancy and lactation affects breast milk composition

(2020) Ignasi Azagra-Boronat et al.   JOURNAL OF DAIRY SCIENCE

Gut Microbial-Derived Metabolomics of Asthma

(2020) Kathleen A. Lee-Sarwar et al.   Metabolites

Bovine IgG Prevents Experimental Infection With RSV and Facilitates Human T Cell Responses to RSV

(2020) Maaike Nederend et al.   Frontiers in Immunology

Bovine milk-derived exosomes enhance goblet cell activity and prevent the development of experimental necrotizing enterocolitis

(2019) Bo Li et al.   PLoS One

Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption

(2019) Nathalie Acevedo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transforming growth factor beta in human milk and allergic outcomes in children: a systematic review

(2019) Ekaterina Khaleva et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Reviewing the evidence on breast milk composition and immunological outcomes

(2019) Alba Boix-Amorós et al.   NUTRITION REVIEWS

Epigenetic Modifications in Placenta are Associated with the Child’s Sensitization to Allergens

(2019) Hani Harb et al.   Biomed Research International

Raw Cow’s Milk Reduces Allergic Symptoms in a Murine Model for Food Allergy—A Potential Role For Epigenetic Modifications

(2019) Abbring et al.   Nutrients

Suppression of Food Allergic Symptoms by Raw Cow’s Milk in Mice is Retained after Skimming but Abolished after Heating the Milk—A Promising Contribution of Alkaline Phosphatase

(2019) Suzanne Abbring et al.   Nutrients

Publisher Correction: Randomized controlled trial on the influence of dietary intervention on epigenetic mechanisms in children with cow’s milk allergy: the EPICMA study

(2019) Lorella Paparo et al.   Scientific Reports

Corrigendum: Sialyllactose and Galactooligosaccharides Promote Epithelial Barrier Functioning and Distinctly Modulate Microbiota Composition and Short Chain Fatty Acid Production In Vitro

(2019) Olaf Perdijk et al.   Frontiers in Immunology

A comparison of exosomes derived from different periods breast milk on protecting against intestinal organoid injury

(2019) Runnan Gao et al.   PEDIATRIC SURGERY INTERNATIONAL

Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy

(2019) Takashi Fujimura et al.   Frontiers in Immunology

It’s Not Mom’s Fault

(2019) Elissa M. Abrams et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

The Beneficial Effect of Farm Milk Consumption on Asthma, Allergies, and Infections: From Meta-Analysis of Evidence to Clinical Trial

(2019) Tabea Brick et al.   Journal of Allergy and Clinical Immunology-In Practice

The role of epigenetics in allergy and asthma development

(2019) Bilal Alashkar Alhamwe et al.   Current Opinion in Allergy and Clinical Immunology

Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis

(2018) Vanessa Garcia-Larsen et al.   PLOS MEDICINE

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

Cow’s Milk and Immune Function in the Respiratory Tract: Potential Mechanisms

(2018) Olaf Perdijk et al.   Frontiers in Immunology

Immunological Effects of Human Milk Oligosaccharides

(2018) Vassilis Triantis et al.   Frontiers in Pediatrics

Early Dietary Intervention with a Mixture of Prebiotic Oligosaccharides Reduces the Incidence of Allergic Manifestations and Infections during the First Two Years of Life

(2018) Sertac Arslanoglu et al.   JOURNAL OF NUTRITION

Induction of Trained Innate Immunity in Human Monocytes by Bovine Milk and Milk-Derived Immunoglobulin G

(2018) Marloes van Splunter et al.   Nutrients

Immunologically Active Components in Human Milk and Development of Atopic Disease, With Emphasis on Food Allergy, in the Pediatric Population

(2018) Puja S. Rajani et al.   Frontiers in Pediatrics

High levels of butyrate and propionate in early life are associated with protection against atopy

(2018) Caroline Roduit et al.   ALLERGY

Raw cow’s milk consumption and allergic diseases – The potential role of bioactive whey proteins

(2018) Suzanne Abbring et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Food-Derived Xeno-microRNAs: Influence of Diet and Detectability in Gastrointestinal Tract-Proof-of-Principle Study

(2018) Jastin Link et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Milk-Derived Exosomes and Metabolic Regulation

(2018) Janos Zempleni et al.   Annual Review of Animal Biosciences

Epigenetic and Transcriptional Regulation in the Induction, Maintenance, Heterogeneity, and Recall-Response of Effector and Memory Th2 Cells

(2018) Atsushi Onodera et al.   Frontiers in Immunology

Exposure to the Chinese famine of 1959–61 in early life and long-term health conditions: a systematic review and meta-analysis

(2017) Chihua Li et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The Neonatal Window of Opportunity: Setting the Stage for Life-Long Host-Microbial Interaction and Immune Homeostasis

(2017) Natalia Torow et al.   JOURNAL OF IMMUNOLOGY

Effects of osteopontin-enriched formula on lymphocyte subsets in the first 6 months of life: a randomized controlled trial

(2017) Christina E West et al.   PEDIATRIC RESEARCH

Epigenetics and allergy: from basic mechanisms to clinical applications

(2017) Daniel P Potaczek et al.   Epigenomics

Can Early Omega-3 Fatty Acid Exposure Reduce Risk of Childhood Allergic Disease?

(2017) Elizabeth Miles et al.   Nutrients

Human Milk and Allergic Diseases: An Unsolved Puzzle

(2017) Daniel Munblit et al.   Nutrients

Postnatal Innate Immune Development: From Birth to Adulthood

(2017) Anastasia Georgountzou et al.   Frontiers in Immunology

The Maternal Diet, Gut Bacteria, and Bacterial Metabolites during Pregnancy Influence Offspring Asthma

(2017) Lawrence E. K. Gray et al.   Frontiers in Immunology

They Are What You Eat: Can Nutritional Factors during Gestation and Early Infancy Modulate the Neonatal Immune Response?

(2017) Sarah Prentice   Frontiers in Immunology

Breastfeeding effects on DNA methylation in the offspring: A systematic literature review

(2017) Fernando Pires Hartwig et al.   PLoS One

Bovine milk-derived exosomes for drug delivery

(2016) Radha Munagala et al.   CANCER LETTERS

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

The microbiome and development of allergic disease

(2016) Susan V. Lynch et al.   Current Opinion in Allergy and Clinical Immunology

Dietary n-3 long chain polyunsaturated fatty acids in allergy prevention and asthma treatment

(2016) Linette E.M. Willemsen   EUROPEAN JOURNAL OF PHARMACOLOGY

Growth, Nutrition, and Cytokine Response of Breast-fed Infants and Infants Fed Formula With Added Bovine Osteopontin

(2016) Bo Lönnerdal et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

(2016) Cesar G Victora et al.   LANCET

Neonatal mucosal immunology

(2016) N Torow et al.   Mucosal Immunology

Effect of bovine lactoferrin from iron-fortified formulas on diarrhea and respiratory tract infections of weaned infants in a randomized controlled trial

(2016) Ke Chen et al.   NUTRITION

Probiotics for allergy prevention

(2016) C.E. West   Beneficial Microbes

Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation

(2016) Bodo C. Melnik et al.   Clinical and Translational Allergy

Mucosal Immune Development in Early Life: Setting the Stage

(2015) Sylvia Brugman et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Consumption of unprocessed cow's milk protects infants from common respiratory infections

(2015) Georg Loss et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Probiotics for the prevention of allergy: A systematic review and meta-analysis of randomized controlled trials

(2015) Carlos A. Cuello-Garcia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Uptake and Function Studies of Maternal Milk-derived MicroRNAs

(2015) Alexandra C. Title et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages

(2015) Hirohisa Izumi et al.   JOURNAL OF DAIRY SCIENCE

Probiotics, prebiotics and synbiotics- a review

(2015) Kavita. R. Pandey et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse

(2015) Mei Ling Xu et al.   JOURNAL OF MICROBIOLOGY

The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells

(2015) Tovah Wolf et al.   JOURNAL OF NUTRITION

Supplementation of Mice with Specific Nondigestible Oligosaccharides during Pregnancy or Lactation Leads to Diminished Sensitization and Allergy in the Female Offspring

(2015) Astrid Hogenkamp et al.   JOURNAL OF NUTRITION

Epigenetics of Inflammation, Maternal Infection, and Nutrition

(2015) Kate J Claycombe et al.   JOURNAL OF NUTRITION

Infections in Infants Fed Formula Supplemented With Bovine Milk Fat Globule Membranes

(2015) Niklas Timby et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models

(2015) Onno J. Arntz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Early infancy microbial and metabolic alterations affect risk of childhood asthma

(2015) Marie-Claire Arrieta et al.   Science Translational Medicine

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Association between type 2 diabetes and prenatal exposure to the Ukraine famine of 1932–33: a retrospective cohort study

(2015) L H Lumey et al.   Lancet Diabetes & Endocrinology

Transcriptional and epigenetic regulation of T-helper lineage specification

(2014) Subhash K. Tripathi et al.   IMMUNOLOGICAL REVIEWS

Nutritional Influences on Epigenetic Programming

(2014) Debra J. Palmer et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

(2014) G. Lal et al.   JOURNAL OF IMMUNOLOGY

Supplementing Pregnant Mice with a Specific Mixture of Nondigestible Oligosaccharides Reduces Symptoms of Allergic Asthma in Male Offspring

(2014) Astrid Hogenkamp et al.   JOURNAL OF NUTRITION

MicroRNAs Are Absorbed in Biologically Meaningful Amounts from Nutritionally Relevant Doses of Cow Milk and Affect Gene Expression in Peripheral Blood Mononuclear Cells, HEK-293 Kidney Cell Cultures, and Mouse Livers

(2014) Scott R. Baier et al.   JOURNAL OF NUTRITION

Oct-1 Regulates IL-17 Expression by Directing Interchromosomal Associations in Conjunction with CTCF in T Cells

(2014) Lark Kyun Kim et al.   MOLECULAR CELL

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Specificity and Effector Functions of Human RSV-Specific IgG from Bovine Milk

(2014) Gerco den Hartog et al.   PLoS One

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

The Influence of Early Life Nutrition on Epigenetic Regulatory Mechanisms of the Immune System

(2014) Lorella Paparo et al.   Nutrients

Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota

(2014) Tadao Enomoto et al.   ALLERGOLOGY INTERNATIONAL

Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation

(2014) Chang H. Kim et al.   Immune Network

Consumption of unpasteurized milk and its effects on atopy and asthma in children and adult inhabitants in rural Poland

(2013) B. Sozańska et al.   ALLERGY

Farm-derived Gram-positive bacteriumStaphylococcus sciuriW620 prevents asthma phenotype in HDM- and OVA-exposed mice

(2013) S. Hagner et al.   ALLERGY

Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy

(2013) S. Michel et al.   ALLERGY

Relevance of pre- and postnatal nutrition to development and interplay between the microbiota and metabolic and immune systems

(2013) Alma J Nauta et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

More than just a gut instinct–the potential interplay between a baby's nutrition, its gut microbiome, and the epigenome

(2013) Mona Mischke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mediterranean diet adherence during pregnancy and risk of wheeze and eczema in the first year of life: INMA (Spain) and RHEA (Greece) mother–child cohort studies

(2013) Leda Chatzi et al.   BRITISH JOURNAL OF NUTRITION

Evidence of preventive effect of probiotics and prebiotics for infantile eczema

(2013) Philippe A. Eigenmann   Current Opinion in Allergy and Clinical Immunology

Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood

(2013) Anna Lluis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

A small jab – a big effect: nonspecific immunomodulation by vaccines

(2013) Christine S. Benn et al.   TRENDS IN IMMUNOLOGY

The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders

(2013) Andrea Horvath Marques et al.   Frontiers in Neuroscience

DNA methylation levels within the CD14 promoter region are lower in placentas of mothers living on a farm

(2012) Gisela G.G. Slaats et al.   ALLERGY

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

Fish oil supplementation in early infancy modulates developing infant immune responses

(2012) N. D'Vaz et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Transcriptional mechanisms that regulate T helper 1 cell differentiation

(2012) Kenneth J Oestreich et al.   CURRENT OPINION IN IMMUNOLOGY

Human milk oligosaccharides: Every baby needs a sugar mama

(2012) L. Bode   GLYCOBIOLOGY

Which factors in raw cow's milk contribute to protection against allergies?

(2012) R.J. Joost van Neerven et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study

(2012) Georg Loss et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases

(2012) Susan L. Prescott   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of short-chain galacto- and long-chain fructo-oligosaccharides on systemic and local immune status during pregnancy

(2012) N. van Vlies et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Microbial contact during pregnancy, intestinal colonization and human disease

(2012) Samuli Rautava et al.   Nature Reviews Gastroenterology & Hepatology

Human Milk Composition

(2012) Olivia Ballard et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Early environments and the ecology of inflammation

(2012) T. W. McDade   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation: a promising landscape for immune system-related diseases

(2012) Beatriz Suarez-Alvarez et al.   TRENDS IN GENETICS

Epigenetics: A New Bridge between Nutrition and Health

(2012) Sang-Woon Choi et al.   Advances in Nutrition

Nutritionally Mediated Programming of the Developing Immune System

(2012) Amanda C. Palmer   Advances in Nutrition

Dietary Immunomodulatory Factors in the Development of Immune Tolerance

(2011) Christina E. West et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Helper T-cell differentiation and plasticity: insights from epigenetics

(2011) Kiyoshi Hirahara et al.   IMMUNOLOGY

The protective effect of farm milk consumption on childhood asthma and atopy: The GABRIELA study

(2011) Georg Loss et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes

(2011) Stephanie Brand et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period?

(2011) Peter Aaby et al.   JOURNAL OF INFECTIOUS DISEASES

Bovine Lactoferrin Prevents Invasive Fungal Infections in Very Low Birth Weight Infants: A Randomized Controlled Trial

(2011) P. Manzoni et al.   PEDIATRICS

Lifestyle and parental allergen sensitization are reflected in the intrauterine environment at gene expression level

(2010) M. Joerink et al.   ALLERGY

Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis

(2010) Stuart F. W. Kendrick et al.   HEPATOLOGY

Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis

(2010) Caroline Roduit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oral tolerance in neonates: from basics to potential prevention of allergic disease

(2010) V Verhasselt   Mucosal Immunology

Silent mysteries: epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune disease

(2009) D. J. Martino et al.   ALLERGY

Neutral and acidic oligosaccharides in preterm infants: a randomized, double-blind, placebo-controlled trial

(2009) Elisabeth AM Westerbeek et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A formula containing galacto- and fructo-oligosaccharides prevents intestinal and extra-intestinal infections: An observational study

(2009) Eugenia Bruzzese et al.   CLINICAL NUTRITION

Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants

(2009) Y. Miyake et al.   EUROPEAN RESPIRATORY JOURNAL

Bovine Lactoferrin Supplementation for Prevention of Late-Onset Sepsis in Very Low-Birth-Weight NeonatesA Randomized Trial

(2009) Paolo Manzoni   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells

(2009) Bianca Schaub et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbeAcinetobacter lwoffiiF78

(2009) Melanie L. Conrad et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Breast-feeding: A Commentary by the ESPGHAN Committee on Nutrition

(2009) Carlo Agostoni et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

At the crossroads of T helper lineage commitment—Epigenetics points the way

(2008) Peter C.J. Janson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Prebiotics, immune function, infection and inflammation: a review of the evidence

(2008) Amy R. Lomax et al.   BRITISH JOURNAL OF NUTRITION

Farm exposure in utero may protect against asthma, hay fever and eczema

(2008) J. Douwes et al.   EUROPEAN RESPIRATORY JOURNAL

A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial

(2008) Kristin Wickens et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In utero supplementation with methyl donors enhances allergic airway disease in mice

(2008) John W. Hollingsworth et al.   JOURNAL OF CLINICAL INVESTIGATION

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA