The Relationship of Sphingosine Kinase 1 With Pyroptosis Provides a New Strategy for Tumor Therapy

Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer

(2020) Jin-Feng Teng et al.   Cancers

Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity

(2020) Małgorzata Krześniak et al.   CELLULAR SIGNALLING

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Macrophage priming is dispensable for NLRP3 inflammasome activation and restriction of Leishmania amazonensis replication

(2019) Renan V. H. Carvalho et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

(2019) Xiaojing Xia et al.   Cell Death & Disease

Neutrophil extracellular traps promote macrophage pyroptosis in sepsis

(2018) Linsong Chen et al.   Cell Death & Disease

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

(2018) Ju Youn Lee et al.   Nature Communications

Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells

(2018) Nathalia Pizato et al.   Scientific Reports

Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain

(2018) Gaëlle Dominguez et al.   Acta Neuropathologica Communications

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Differential roles of caspase-1 and caspase-11 in infection and inflammation

(2017) Si Ming Man et al.   Scientific Reports

Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy

(2016) Yoshihiro Komohara et al.   ADVANCED DRUG DELIVERY REVIEWS

CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1

(2016) W Zhu et al.   ONCOGENE

Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma

(2016) Qun Chu et al.   Oncotarget

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Macrophage heterogeneity in tissues: phenotypic diversity and functions

(2014) Siamon Gordon et al.   IMMUNOLOGICAL REVIEWS

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Coupling between endocytosis and sphingosine kinase 1 recruitment

(2014) Hongying Shen et al.   NATURE CELL BIOLOGY

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression

(2013) Qing Wei et al.   LABORATORY INVESTIGATION

Molecular Basis of Sphingosine Kinase 1 Substrate Recognition and Catalysis

(2013) Zhulun Wang et al.   STRUCTURE

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

(2011) Nadia M. Luheshi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Diversity and plasticity of mononuclear phagocytes

(2011) Siamon Gordon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells

(2010) A. Weigert et al.   BLOOD

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

(2009) Kate E. Jarman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY