Treatment of COVID-19 With Conestat Alfa, a Regulator of the Complement, Contact Activation and Kallikrein-Kinin System

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

(2020) Bo Shen et al.   CELL

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence

(2020) Julien Poissy et al.   CIRCULATION

Will Complement Inhibition Be the New Target in Treating COVID-19–Related Systemic Thrombosis?

(2020) Courtney M. Campbell et al.   CIRCULATION

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study

(2020) Julie Helms et al.   INTENSIVE CARE MEDICINE

Complement activation in patients with COVID-19: A novel therapeutic target

(2020) Massimo Cugno et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

(2020) Tobias Herold et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

COVID-19 illness in native and immunosuppressed states: A clinical–therapeutic staging proposal

(2020) Hasan K. Siddiqi et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Well-aerated Lung on Admitting Chest CT to Predict Adverse Outcome in COVID-19 Pneumonia

(2020) Davide Colombi et al.   RADIOLOGY

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases

(2020) Cynthia Magro et al.   Translational Research

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

(2020) Sara Mastaglio et al.   CLINICAL IMMUNOLOGY

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

(2018) Chhinder P. Sodhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV

(2018) Yuting Jiang et al.   Emerging Microbes & Infections

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities

(2016) A. H. Schmaier   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Treatment With Anti-C5a Antibody Improves the Outcome of H7N9 Virus Infection in African Green Monkeys

(2014) Shihui Sun et al.   CLINICAL INFECTIOUS DISEASES

Inhibition of Complement Activation Alleviates Acute Lung Injury Induced by Highly Pathogenic Avian Influenza H5N1 Virus Infection

(2013) Shihui Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Characterization of recombinant human C1 inhibitor secreted in milk of transgenic rabbits

(2012) Harrie A. van Veen et al.   JOURNAL OF BIOTECHNOLOGY

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

(2012) D. Heja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C1-esterase inhibitor infusion increases survival rates for patients with sepsis*

(2011) Anton A. Igonin et al.   CRITICAL CARE MEDICINE

A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms

(2010) Y. Zhou et al.   JOURNAL OF VIROLOGY