Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function

(2020) Henry Kurniawan et al.   Cell Metabolism

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

(2020) Xiaoguang Liu et al.   NATURE CELL BIOLOGY

Pharmacologic inhibition of lysine-specific demethylase 1 as a therapeutic and immune-sensitization strategy in pediatric high-grade glioma

(2020) Cavan P Bailey et al.   NEURO-ONCOLOGY

Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent medulloblastoma and ependymoma

(2020) Soumen Khatua et al.   NEURO-ONCOLOGY

LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML

(2019) Jessica Barth et al.   LEUKEMIA

Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance

(2019) Xiaohu Zheng et al.   NATURE IMMUNOLOGY

The timeline of epigenetic drug discovery: from reality to dreams

(2019) A. Ganesan et al.   Clinical Epigenetics

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

(2018) Wanqiang Sheng et al.   CELL

Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells

(2018) Adam Cribbs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

(2018) Archana Sehrawat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Enhancer of zeste homolog 2 (EZH2) induces natural killer cell-mediated eradication of hepatocellular carcinoma cells

(2018) Suresh Bugide et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade

(2018) Ye Qin et al.   ONCOGENE

The Cancer Epigenome: Exploiting Its Vulnerabilities for Immunotherapy

(2018) Helen Loo Yau et al.   TRENDS IN CELL BIOLOGY

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

(2018) Xavier Michelet et al.   NATURE IMMUNOLOGY

PARP1-LSD1 functional interplay controls transcription of SOD2 that protects human pro-inflammatory macrophages from death under an oxidative condition

(2018) Paulina Tokarz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

(2017) R Sinha et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Immune dysfunction and increased oxidative stress state in diet-induced obese mice are reverted by nutritional supplementation with monounsaturated and n-3 polyunsaturated fatty acids

(2017) Caroline Hunsche et al.   EUROPEAN JOURNAL OF NUTRITION

Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

(2017) Ramasamy Jagadeeswaran et al.   EXPERIMENTAL HEMATOLOGY

Glutathione Primes T Cell Metabolism for Inflammation

(2017) Tak W. Mak et al.   IMMUNITY

The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate

(2017) Pranavi Koppula et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry

(2017) Jacquelyn Freund-Brown et al.   JOURNAL OF IMMUNOLOGY

H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1

(2016) Dezhi Zhao et al.   Cell Reports

Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells

(2015) A. Sakamoto et al.   CANCER RESEARCH

Adenanthin, a new inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells

(2015) Marta Siernicka et al.   IMMUNOLOGY

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity

(2015) Jie Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth

(2014) S. Sankar et al.   CLINICAL CANCER RESEARCH

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione

(2014) John P. Richie et al.   EUROPEAN JOURNAL OF NUTRITION

Epigenetic modifications of Nrf2-mediated glutamate–cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression

(2014) Manish Mishra et al.   FREE RADICAL BIOLOGY AND MEDICINE

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

(2014) W Fiskus et al.   LEUKEMIA

Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1

(2013) V. Nandakumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

(2013) Marc A Kerenyi et al.   eLife

Effects of Reactive Nitrogen Scavengers on NK-Cell-Mediated Killing of K562 Cells

(2012) Yili Zeng et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation

(2012) A Sprüssel et al.   LEUKEMIA

FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure

(2012) Shinjiro Hino et al.   Nature Communications

Cystine and Theanine Supplementation Restores High-Intensity Resistance Exercise-Induced Attenuation of Natural Killer Cell Activity in Well-Trained Men

(2010) Shigeo Kawada et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

An attempt to prevent senescence: A mitochondrial approach

(2008) Vladimir P. Skulachev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Glutathione diminishes tributyltin- and dibutyltin-induced loss of lytic function in human natural killer cells

(2008) Jeralyn J. Powell et al.   DRUG AND CHEMICAL TOXICOLOGY

Natural Killer Cells, Glutathione, Cytokines, and Innate Immunity Against Mycobacterium tuberculosis

(2008) Ariel C. Millman et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Low natural killer cell cytotoxic activity in autism: The role of glutathione, IL-2 and IL-15

(2008) Aristo Vojdani et al.   JOURNAL OF NEUROIMMUNOLOGY