Infectious Tolerance as Seen With 2020 Vision: The Role of IL-35 and Extracellular Vesicles

Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance

(2020) Jeremy A. Sullivan et al.   Cell Reports

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

(2019) Deepali V. Sawant et al.   NATURE IMMUNOLOGY

Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells

(2019) Christopher J.M. Piper et al.   Cell Reports

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

(2018) Yi Yang et al.   CELL RESEARCH

CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages

(2018) Anushka N. Samudra et al.   JOURNAL OF AUTOIMMUNITY

TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity

(2018) Paloma Riquelme et al.   Nature Communications

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance

(2017) William Bracamonte-Baran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Graft-Infiltrating PD-L1hi Cross-Dressed Dendritic Cells Subvert Donor-Reactive T Cell Responses in Mouse Liver Transplant Tolerance

(2017) Yoshihiro Ono et al.   TRANSPLANTATION

Erratum: Donor-derived exosomes induce specific regulatory T cells to suppress immune inflammation in the allograft heart

(2017) Jiangping Song et al.   Scientific Reports

Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms

(2017) Laurent Muller et al.   OncoImmunology

Th17 Responses to Collagen Type V, kα1-Tubulin, and Vimentin Are Present Early in Human Development and Persist Throughout Life

(2016) J. A. Sullivan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Donor-derived exosomes

(2016) Adrian E. Morelli et al.   Current Opinion in Organ Transplantation

Interleukin-35 Limits Anti-Tumor Immunity

(2016) Meghan E. Turnis et al.   IMMUNITY

Donor dendritic cell–derived exosomes promote allograft-targeting immune response

(2016) Quan Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

The Discovery and Early Days of TGF-β: A Historical Perspective

(2016) Harold L. Moses et al.   Cold Spring Harbor Perspectives in Biology

Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets

(2016) Laurent Muller et al.   Scientific Reports

Mucosal Administration of Collagen V Ameliorates the Atherosclerotic Plaque Burden by Inducing Interleukin 35-dependent Tolerance

(2015) Arick C. Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Requirement for P2X7R Function in IL-17 Dependent vs. IL-17 Independent Cellular Immune Responses

(2014) J. A. Sullivan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human CD4+CD39+regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+exosomes or CD73+cells

(2014) P. J. Schuler et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Function of the tetraspanin molecule CD81 in B and T cells

(2014) Shoshana Levy   IMMUNOLOGIC RESEARCH

Interleukin-35 induces regulatory B cells that suppress autoimmune disease

(2014) Ren-Xi Wang et al.   NATURE MEDICINE

Recombinant p35 from Bacteria Can Form Interleukin (IL-)12, but Not IL-35

(2014) Samadhi Aparicio-Siegmund et al.   PLoS One

Extracellular Adenosine-Mediated Modulation of Regulatory T Cells

(2014) Akio Ohta et al.   Frontiers in Immunology

CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+T cells contributes to their regulatory function

(2013) Lesley Ann Smyth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunosuppression minimization vs. complete drug withdrawal in liver transplantation

(2013) Maria-Carlota Londoño et al.   JOURNAL OF HEPATOLOGY

Interleukin 35: A Key Mediator of Suppression and the Propagation of Infectious Tolerance

(2013) Brian M. Olson et al.   Frontiers in Immunology

Regulation of Lymphocyte Function by Adenosine

(2012) Joel Linden et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of adenosine A2A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice

(2012) Cirle Alcantara Warren et al.   BMC INFECTIOUS DISEASES

Human Prostate Tumor Antigen-Specific CD8+ Regulatory T Cells Are Inhibited by CTLA-4 or IL-35 Blockade

(2012) B. M. Olson et al.   JOURNAL OF IMMUNOLOGY

The composition and signaling of the IL-35 receptor are unconventional

(2012) Lauren W Collison et al.   NATURE IMMUNOLOGY

Purinergic Signaling during Inflammation

(2012) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

The battle against immunopathology: infectious tolerance mediated by regulatory T cells

(2011) David M. Gravano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

(2011) M. J. Szczepanski et al.   HAEMATOLOGICA

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Interleukin-17–Dependent Autoimmunity to Collagen Type V in Atherosclerosis

(2010) Melanie L. Dart et al.   CIRCULATION RESEARCH

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

Much Ado about Adenosine: Adenosine Synthesis and Function in Regulatory T Cell Biology

(2010) P. B. Ernst et al.   JOURNAL OF IMMUNOLOGY

IL-35-mediated induction of a potent regulatory T cell population

(2010) Lauren W Collison et al.   NATURE IMMUNOLOGY

Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg)

(2010) Marta Szajnik et al.   PLoS One

Reexposure of cord blood to noninherited maternal HLA antigens improves transplant outcome in hematological malignancies

(2009) J. J. van Rood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

Induction of myeloid-derived suppressor cells by tumor exosomes

(2008) Xiaoyu Xiang et al.   INTERNATIONAL JOURNAL OF CANCER